Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Abstract

Objective Disorders in glucose and lipid metabolism have been shown to exert an influence on bone metabolism. The TyG index, which combines measures of glucose and triglycerides, provides insights into the overall metabolic status. However, the investigation of concurrent disturbances in glucose and lipid metabolism and their specific implications for bone metabolism remains limited in the existing research literature. This study aimed to explore the correlation between the TyG index and bone mineral density (BMD) in US adults. Methods In the National Health and Nutrition Examination Survey (NHANES), subjects were classified based on the TyG index into four groups (< 7.97, 7.97–8.39, 8.39–8.85, > 8.86). Linear regression analysis was conducted to determine the β value and 95% confidence interval (CI). Four multivariable models were constructed. Restricted cubic spline analyses and piecewise linear regression were employed to identify the association between the BMD and TyG index. An analysis of subgroups was also conducted in this study. Results Significant variations in related characteristics were found among the US adult population, who were distributed into four groups based on the quartiles of the TyG index. A negative correlation between the TyG index and lumbar spine BMD was observed. In the multi-adjusted models, compared to Q1 of the TyG index, the β for Q4 of the TyG index for lumbar spine BMD was [β = − 0.008, 95% CI (− 0.017, 0)] in US adults. The association between the TyG index and lumbar spine BMD was found to be nonlinear (all nonlinear p < 0.001), with a threshold value based on restricted cubic spline analyses. Above the threshold point, the β for lumbar spine BMD was − 0.042 (95% CI, − 0.059, − 0.024). Below the threshold points, no significant difference was observed (p > 0.05). No significant interactions were observed among subgroups based on age, gender, presence of diabetes, BMI, and use of antidiabetic and antihyperlipidemic agents. Similar patterns of association were observed in total and subtotal bone density. Conclusions This study identified a nonlinear association between the TyG index and BMD in the US population. Furthermore, an increased level of the TyG index may indicate a higher risk of osteoporosis among US adults. These findings highlight the importance of considering glucose and lipid metabolism disturbances in understanding bone health and the potential for developing preventive strategies for osteoporosis.

Association between triglyceride glucose index and total bone mineral density: a cross-sectional study from NHANES 2011–2018

“…Moreover, African Americans have lower triglyceride levels than non-Hispanic Whites at a given level of IR. Intriguingly, a divergent study with a similar focus on adults, highlighting a negative correlation between TyG and BMD 85 , introduces a notable contrast to our findings. It's crucial to acknowledge that our study included children but excluded postmenopausal females, potentially creating unique subsets within age and gender subgroups.…”

Effects of Tail Vegetable Fermented Feed on the Growth and Rumen Microbiota of Lambs

“…Blood metabolites, produced during metabolism, serve as crucial indicators of animal health, nutrient utilization, and overall metabolic activity [24,25]. Serum triglycerides (TG) and cholesterol (CHO) levels are key to assessing lipid metabolism, with higher concentrations indicating increased fat deposition [26,27]. In this study, the LC group exhibited a 14.81% reduction in serum TG content compared to the LB and LA groups and a 12.90% decrease compared to the LA group alone.…”

“…Antioxidant enzymes maintain a balance between oxidation and antioxidation when animals are in a normal physiological state. However, when the body is stimulated by various stimuli, oxidative stress will occur, which will cause damage to tissues and cells, resulting in the decrease of T-AOC, T-SOD, and GSH-Px [26,27]. Excessive free radicals will disrupt the oxidative balance in the body, leading to excessive oxidation, and eventually leading to apoptosis [1,4].…”