Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children

Meza‐Velázquez, Rocío; López-Márquez, Francisco Carlos; Espinosa-Padilla, S; Rivera-Guillén, Mario Alberto; Gutiérrez-Díaz, Nancy; Pérez-Armendáriz, L; Rosales-González, Manuel

doi:10.1016/j.aller.2016.01.002

Cited by 14 publications

(16 citation statements)

References 24 publications

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“…In the light of the proposed diagnostic criteria, it is worth emphasizing that HIT may be, and in most cases probably is, a comorbidity. This is supported by studies correlating DAO/HNMT deficit (measured by SNPs) or increases in blood serum histamine concentrations with the severity of allergic diseases like atopic dermatitis, allergic rhinitis or asthma and bronchial hyperresponsiveness [ 15 , 16 , 18 , 19 ]. Additionally, DAO deficits were observed in bowel diseases, for example, celiac disease or acute gastroenteritis in children [ 21 , 22 ] and recurrent urticaria, colon adenoma, carbohydrate malabsorption as well as food allergies in adults [ 30 , 32 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Comorbiditiesmentioning

confidence: 85%

“…It appears that HNMT SNPs are associated with more severe courses of atopic dermatitis and allergic rhinitis while for asthma and bronchial hyperresponsiveness the results are contradictory. The relationship between the SNPs in the HNMT gene (N-methyltransferase C314 allele) and allergic diseases was investigated in children in several studies [15][16][17][18][19]. It ap pears that HNMT SNPs are associated with more severe courses of atopic dermatitis an allergic rhinitis while for asthma and bronchial hyperresponsiveness the results are con tradictory.…”

Section: Primary (Genetic) Histamine Intolerancementioning

confidence: 99%

“…SNPs in the promoter region that decrease the DAO gene expression (rs2052129) have also been reported [ 13 ]. Similarly to the adult population, the DAO SNP rs1049793 is also associated with lower DAO activity in children and leads to higher serum histamine levels in paediatric patients with allergic rhinitis [ 15 ].…”

Section: Primary (Genetic) Histamine Intolerancementioning

confidence: 99%

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Histamine Intolerance in Children: A Narrative Review

et al. 2021

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Histamine intolerance is defined as a disequilibrium of accumulated histamine and the capacity for histamine degradation. This clinical term addresses a non-immunologically mediated pathology when histamine ingested with food is not particularly high, however its degradation is decreased. This paper aims to provide a narrative review on etiopathology, epidemiology, possible diagnostic algorithms and diagnostic challenges of histamine intolerance in children. The clinical picture of histamine intolerance in children is similar to that observed in adults apart from male predominance found in paediatric patients. Both in children and adults, a histamine-reduced diet is typically the treatment of choice. Diamine oxidase supplementation offers another treatment option. There is no symptom or test pathognomonic for histamine intolerance. Nevertheless, manifestations of chronic gastrointestinal symptoms, measurements of diamine oxidase deficits, positive results of histamine provocation tests and improvement in symptoms with histamine-reduced diet considerably increase the probability of histamine intolerance diagnosis. These factors have been included in the proposed diagnostic algorithm for histamine intolerance. In children histamine intolerance most likely co-occurs with allergies and bowel diseases, which creates an additional diagnostic challenge. As the evidence for children is poor further research is needed the determine epidemiology, validate diagnostic algorithms and establish possible treatment options regarding histamine intolerance.

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Section: Comorbiditiesmentioning

confidence: 85%

Section: Primary (Genetic) Histamine Intolerancementioning

confidence: 99%

Section: Primary (Genetic) Histamine Intolerancementioning

confidence: 99%

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Histamine Intolerance in Children: A Narrative Review

et al. 2021

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“…Some clinical studies have correlated DAO deficiency with specific pathologies, mainly gastrointestinal, dermatological diseases or migraine [ 6 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], depending on the expression of histamine receptors (H1 – H4) in tissues [ 16 ]. However, there is little information available about DAO function in patients diagnosed with AR and its correlation with symptoms [ 17 , 18 , 19 ]. The aim of this study is to analyze the DAO degradation activity in patients with persistent AR.…”

Section: Introductionmentioning

confidence: 99%

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Mayo‐Yáñez¹,

Díaz-Díaz²,

Vázquez-Barro³

et al. 2021

ALS

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Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis. Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow. Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 – 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010). Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.

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“…3 Single-nucleotide polymorphisms (SNPs) are also implicated in the pathophysiology of AR. [4][5][6][7][8] Transforming growth factor beta (TGF-b) is a cytokine functioning in a large variety of activities including chemotaxis of inflammatory cells, cell proliferation, immune responses, tissue repair, and fibrosis. 9 Three closely related isoforms, TGF-b1, -b2 and -b3, have been identified in mammals.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism –509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population

Zhu

Chen

et al. 2020

Am J Rhinol�Allergy

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Background Polymorphism –509C/T in the promoter of transforming growth factor beta1 ( TGFB1) gene is implicated in the pathogenesis of asthma. This polymorphism might also act to regulate the development of allergic rhinitis (AR). Objectives To investigate whether –509C/T is associated with AR susceptibility and severity in a Han Chinese population. Methods The study enrolled 263 patients with persistent AR and 249 healthy controls. AR patients were classified as mild or moderate/severe AR groups according to the Allergic Rhinitis and its Impact on Asthma classification. TGFB1 gene polymorphism –509C/T was genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum total Immunoglobulin E (IgE) and specific IgE levels were determined using an ImmunoCAP. Results Significant difference was found in the allele frequency of TGFB1 –509C/T between AR patients and healthy controls ( P = .027) but not in the genotype frequency ( P =.051). However, the genotype frequency of TGFB1 –509C/T showed significant difference between the mild AR group, the moderate/severe AR group, and the control group ( P = .012); between the moderate/severe AR group and the control group ( P =.036); between the mild AR group and the moderate/severe AR group ( P = .038); but not between the mild AR group and the control group ( P =.075). Conclusion TGFB1 promoter polymorphism –509C/T may be associated with the susceptibility and the severity of persistent AR of Han Chinese, but the functional relationship still needs clarification.

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Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children

Abstract: The presence of these SNPs in patients with allergic rhinitis can lead to higher serum histamine, therefore to a higher risk of developing more severe symptoms or more associated allergic diseases, even if the serum IgE remains low.

Cited by 14 publications

References 24 publications

Histamine Intolerance in Children: A Narrative Review

Histamine Intolerance in Children: A Narrative Review

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Polymorphism –509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population

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