Association Between Type D Personality, Depression, and Oxidative Stress in Patients With Chronic Heart Failure

Kupper, Nina; Gidron, Yori; Winter, Jobst B.; Denollet, Johan

doi:10.1097/psy.0b013e3181bee6dc

Cited by 74 publications

(62 citation statements)

References 53 publications

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“…EJCPR indicates Eur J Cardiovasc Prev Rehabil; JACC, J Am Coll Cardiol; and JHLT, J Heart Lung Transplant. D remained significantly related to increased levels of cortisol 53,54 and oxidative stress, 55 after adjustment for depressive symptoms.…”

Section: Differences Between Type D Personality and Depressionmentioning

confidence: 86%

“…22,23,27,41,42,49 This suggests that both constructs involve distinct pathways of disease. Evidence also shows that after control for depressive symptoms, Type D was associated with ventricular arrhythmia, 52 increased cortisol, 53,54 and oxidative stress 55 in cardiac patients. Further, Type D predicted the onset, 33 prevalence, 36,46,47 persistence, 35,48 and severity 37 of depression and anxiety symptoms in cardiac patients, adjusting for baseline depression scores.…”

Section: Type D Is Not Depressionmentioning

confidence: 99%

“…In heart failure patients, Type D personality is associated with increased activity of proinflammatory cytokines 95 and a dysfunctional cytokine network. 96 Other heart failure studies found that Type D was independently associated with increased oxidative stress 55 and that bone marrow-derived progenitor cells numbers were reduced by more than 50% in Type D as compared with non-Type D patients. 97 Behavioral mechanisms include an unhealthy lifestyle, 73 low adherence to medical treatment, 74,75 and reluctance to consult clinical staff.…”

Section: Biological and Behavioral Pathwaysmentioning

confidence: 99%

See 2 more Smart Citations

A General Propensity to Psychological Distress Affects Cardiovascular Outcomes

Denollet

Schiffer

Spek

2010

Circ: Cardiovascular Quality and Outcomes

Self Cite

245

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Section: Differences Between Type D Personality and Depressionmentioning

confidence: 86%

Section: Type D Is Not Depressionmentioning

confidence: 99%

Section: Biological and Behavioral Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

A General Propensity to Psychological Distress Affects Cardiovascular Outcomes

Denollet

Schiffer

Spek

2010

Circ: Cardiovascular Quality and Outcomes

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245

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“…According to one theory, oxidative stress plays the key role in this pathological depigmentation (e.g., Bickers and Athar 2006;Namazi 2007). Studies by Cernak et al (2000), Kupper et al (2009), and others showed psychological stress to be one of the factors inducing the production of reactive oxygen forms (ROS), which indicates that oxidative stress could be an element linking emotions and the mechanisms responsible for pigmentation processes. Other authors are of the opinion that neuropeptides and nerve growth factors (NGF), which are the key controllers of emotional reactions, may induce vitiligo in subjects predisposed to the development of this medical condition (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Sitek

Żądzińska

Rosset

2012

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The effects of psychological stress, gender and age on hair and skin pigmentation levels were evaluated in the reported study. The material included Polish high-school and university students aged 18-22 (in the age range 17.50-22.49). All subjects who had sunbathed or used tanning beds or lamps, skin tanning agents, tanning extenders and/or medical agents affecting skin pigmentation during the 60 days preceding the beginning of the study were excluded. The use of hormonal contraceptives within a month prior to the study was also an excluding factor. Stress levels were evaluated by the Perceived Stress Scale (PSS-10) in the Polish adaptation, while hair and skin pigmentation levels were assessed with a dermaspectrometer (Cortex Technology®, Denmark, 2007). The study was carried out with the exclusion of the summer period. Skin pigmentation was evaluated in 395 subjects (264 women and 131 men). Hair pigmentation was analyzed in a smaller group of 351 subjects (223 women and 128 men), as some had had their hair dyed within 12 months prior to the study while in some others the hair was too short to be correctly measured. Regardless of their age, the studied women felt much more stress related to their life situation and were characterized by stronger skin pigmentation than the examined men. No sex differences were identified with regard to hair pigmentation. In the studied period of ontogenesis (18-22 years of age), hair pigmentation levels increased with age, while skin melanization remained stable. Disregarding the effects of age and sex, the level of perceived stress was negatively correlated with skin pigmentation levels; no such relationship was found for hair melanization.

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“…After adjusting for depression, Type D personality independently predicted increased cortisol levels in healthy individuals (Habra, 2003) and both increased cortisol (Whitehead et al, 2007) and oxidative stress (Kupper, Gidron, Winter, & Denollet, 2009) in cardiac patients. As such, it is likely that maladaptive psychological and behavioral responses to stress that are linked to the Type D profile are also associated with chronic physiological changes that are deleterious to the health of the individual by increasing susceptibility to disease and aging (Habra, 2003;Rosmond & Björntorp, 2000) .…”

Section: Type D Personality and Health Outcomesmentioning

confidence: 99%

Statistically Modelling the Relationships between Type D Personality and Social Support, Health Behaviors and Symptom Severity in Chronic Illness Groups

Horwood¹,

Anglim²,

Tooley³

2017

Preprint

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Objective: The study aimed to develop a predictive model of how Type D personality influences health behaviors, social support, and symptom severity and assess its generalizability to a range of chronic illnesses. Design: Participants were classified as either healthy (n = 182) or having a chronic illness (n = 207). Participants completed an online survey measuring Type D and a range of health-related variables. Chronic illness participants were classified as having either a functional somatic syndrome (i.e. chronic fatigue syndrome or fibromyalgia), where the underlying pathological processes were unclear, or illnesses such as type 2 diabetes, osteoarthritis, or rheumatoid arthritis, where the causes are well understood. Main Outcome Measures: Outcome measures were health behaviors, social support, and both physical and psychological symptoms. Results: The rate of Type D was higher in chronic illness participants (53%) than in healthy controls (39%). Negative affectivity (NA) and social inhibition (SI) both correlated with outcome measures, although NA was generally the stronger predictor. Using NA and SI as independent subscales led to superior prediction of health outcomes than using categorical or continuous representations. Conclusion: Findings suggest that the relationship between Type D and health outcomes may generalize across different chronic illnesses.

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Association Between Type D Personality, Depression, and Oxidative Stress in Patients With Chronic Heart Failure

Abstract: CHF patients with Type D personality are characterized by an increased oxidative stress burden, apparent in the decreased antioxidant levels and an increased oxidative stress ratio.

Cited by 74 publications

References 53 publications

A General Propensity to Psychological Distress Affects Cardiovascular Outcomes

A General Propensity to Psychological Distress Affects Cardiovascular Outcomes

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Statistically Modelling the Relationships between Type D Personality and Social Support, Health Behaviors and Symptom Severity in Chronic Illness Groups

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