Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer

Molano, Mónica; Moreno‐Acosta, Pablo; Morales, N.; Burgos, Marcela; Buitrago, Lina; Gamboa, Óscar; Alvarez, Rayner; Garland, Suzanne M.; Tabrizi, Sepehr N.; Steenbergen, Renske D.M.; Mejía, Juan Carlos

doi:10.21873/cgp.20011

Cited by 13 publications

(9 citation statements)

References 38 publications

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“…Epigenetic regulation of the hTERT gene could also be important to evaluate, as some researchers have shown that methylation play a key role in the regulation of hTERT, although contradictory results have been reported ( 40 – 43 ). Recently we have published an association between type specific HPV infections and hTERT methylation in patients with cervical cancer but additional studies in patients with HGSIL have to be done ( 44 ). In addition, lifestyle aspects including diet, exposure to stress, and level of physical activity can also produce changes in TA ( 45 – 47 ).…”

Section: Discussionmentioning

confidence: 99%

Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study

et al. 2017

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Epidemiological information on telomerase activity (TA) and development of cervical lesions is scarce. A nested case-control study was carried out within a cohort of Colombian women tested for Human Papillomavirus (HPV). Measurement of TA was done in cervical scrapes of 25 women who developed High Grade Squamous Intraepithelial Lesion (HGSIL) during the first 6 years of follow-up and was compared with that of 104 control women who maintained normal cytology during the entire follow-up. TA was measured by a telomerase repeat amplification protocol-ELISA. TA and HPV infections were significantly more frequent in cases than in controls. Likewise, 68% of the cases were positive for both TA and HPV compared with only 7.7% of the controls (P<0.0001). Factors independently associated with increased odds of HGSIL included TA, high risk HPV (hrHPV) infections and multiple parities. When restricted to hrHPV positive women, TA was strongly associated with increased odds of HGSIL (adjusted odds ratio=37.94, 95% confidence interval, 1.64–678.1). In addition to an infection with hrHPV, TA appears to be a significant cofactor for HGSIL.

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Section: Discussionmentioning

confidence: 99%

Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study

et al. 2017

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“…Based on the results, we speculated that the interaction of rs807181 and 807183 affected the ATG4A gene and down-regulated or inhibited its role in autophagy, which led to an increased susceptibility and ability of HPV to bind to the host. Some studies have shown that SNP-SNP interactions were notably associated with BMI ( 30 , 31 ), as well as colon cancer. The association between ATG4A genetic variations and HPV infection is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Nucleotide variation in ATG4A and susceptibility to cervical cancer in Southwestern Chinese women

Mao

Wang

et al. 2017

Oncol Lett

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Early detection of human papillomavirus (HPV) is important for the clinical diagnosis of cervical cancer. However, to date, the pathogenesis of cervical cancer is still unclear. Autophagy is a dynamic process that contributes to the maintenance of cellular homeostasis. Here, we investigate whether variants of autophagy genes affect the occurrence of cervical cancer. In this study, our results indicate that single nucleotide polymorphisms (SNPs) of autophagy-related protein 4 (ATG4), including rs4036579, rs5973822, rs807181, rs807182 and rs807183, have a significant relationship with cervical cancer risk. Furthermore, stratified analysis suggests that the homozygous variant genotype could decrease the risk of cervical cancer and should be considered when investigating the role of HPV in cervical cancer. We aim to investigate whether SNPs of ATG4A contribute to HPV infection in the population of Southwestern China. The association of both single SNPs and SNP-SNP interactions with HPV was evaluated in a sample of cancer cases and healthy control subjects. The interaction of rs807181 and rs807183 was associated with HPV infection in case and control subjects (combined P=2.00×10−3 and 3.22×10−2, respectively). This result showed that ATG4A SNP interactions may affect HPV infection in the population of Southwestern China. Notably, the autophagy gene ATG4A may contribute to cervical cancer.

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“…The results of our studies showed that response to treatment, gene expression, and protein expression in the presence of high-risk HPV and variants of HPV-16 were linked. Through these studies, we contributed to the identification of predictive and prognostic biomarkers [ 10 – 15 ]. Recent analyses have aimed at improving the assessment of patients' individual risks [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

Moreno‐Acosta

Romero‐Rojas

Vial

et al. 2020

Case Reports in Obstetrics and Gynecology

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This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.

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Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer

Abstract: Cervical cancer remains one of the most common cancers in women worldwide. According to GLOBOCAN statistics on cervical cancer (1), there were approximately 528,000

Cited by 13 publications

References 38 publications

Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study

Telomerase activity in cervical scrapes of women with high‑grade cervical disease: A nested case-control study

Nucleotide variation in ATG4A and susceptibility to cervical cancer in Southwestern Chinese women

Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

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