Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss

Koide, Yusuke; Teranishi, Masaaki; Sugiura, Saiko; Uchida, Yuzo; Nishio, Naoki; Kato, Ken; Otake, Hironao; Yoshida, Tadao; Otsuka, Rei; Ando, Fujiko; Shimokata, Hiroshi; Hasegawa, Yasuhisa; Nakashima, Tsutomu

doi:10.5152/iao.2018.5442

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…28 Data in the current literature show that several genetic polymorphisms correlated with oxidative stress, inflammation, thrombosis, and blood vessel permeability are associated to SSNHL predisposition and development. 10,12,20,24,28,36,37,40,41 On the basis of this evidence, it could be hypothesized that genetic factors could play a role in maintaining the delicate balance between ROS and antioxidants, pro-inflammatory and anti-inflammatory factors, proaggregants, and antiaggregants; since the balance among these factors is important for the inner ear homeostasis, their disruption could be a factor contributing to the ISSNHL onset. Furthermore, a possible link between SSNHL and major cardiovascular diseases, such as stroke and myocardial infarction, has been previously highlighted.…”

Section: Discussionmentioning

confidence: 99%

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Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

et al. 2020

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Objective: To investigate the association between genetic polymorphisms and sudden sensorineural hearing loss (SSNHL). Most of the SSNHL cases still remain idiopathic, and several etiopathogenetic hypotheses, including a genetic predisposition, have been proposed. Methods: A literature review was conducted using different databases: Medline/PubMed, EMBASE, and CINAHL, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All databases have been searched from May 2016 to April 2020. Results: Genetic susceptibility could represent a key element in the pathogenesis of SSNHL. A number of genetic polymorphisms related to (1) inner ear microvascular disease and endothelial dysfunction and (2) to inner ear oxidative stress and inflammation have been addressed in the current literature. Conclusions: The potential identification of a genetic profile related to SSNHL could provide a more accurate prognostic evidence of idiopathic SSNHL (ISSNHL), offering to the patients not only early-prevention strategies but eventually information on various inheritance modalities.

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Section: Discussionmentioning

confidence: 99%

“…Koide et al 37 reported a significant association between the mitochondrial uncoupling protein 2 (UCP2) polymorphism and the risk of SSNHL onset. UCP2 plays an important protective role against free radicals in the inner ear.…”

Section: Genetic Polymorphisms and Inner Ear Inflammation And/or Oxidative Stressmentioning

confidence: 99%

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

et al. 2020

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“…Keywords: epidemiological studies, hearing impairment, screening, questionnaire, chronic general somatic pathology _________________________________________________________________________________________________  ВВЕДЕНИЕ Исследования, посвященные сенсоневральной тугоухости (СНТ), занимают в настоящее время одно из ведущих направлений не только в оториноларингологической практике, но и в медицине в целом [1,2]. Это обусловлено негативной тенденцией к увеличению пациентов с патологией звуковоспринимающей части слухового анализатора [1,3,4], полиэтиологичностью и генетической детерминированностью заболевания [5][6][7], наличием большого количества общесоматических заболеваний, симтомокомплекс которых включает нарушения в слуховом анализаторе [7][8][9][10][11]. Выраженные нарушения слуха приводят к инвалидности и требуют больших финансово-экономических затрат со стороны как пациента, так и от государственных структур [11][12][13][14]16].…”

Section: Purposeunclassified

Epidemiological Studies to Detect Hearing Impairment in Adults with Chronic General Somatic Pathology

Лазарева,

Азаматова,

Коваленко

et al. 2023

Оториноларингология. Восточная Европа

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Цель. Оценка результатов эпидемиологического скринингового исследования по выявлению начальных форм сенсоневральной тугоухости среди пациентов с хронической общесоматической патологией в отдельно взятом регионе. Материалы и методы. Использован способ скрининговой диагностики нарушений слуховой функции компьютерной программой СЛУХ-info, основанный на результатах анкетирования пациентов, первично не предъявляющих жалоб на нарушение слуха. В исследовании приняли участие 5604 пациента с различными формами хронической общесоматической патологии. Анкетирование проводилось анонимно. Результаты. Проведенное анкетирование, основанное на балльной оценке психоэмоционального состояния пациента в различных аудиторных условиях, позволило определить группы риска по развитию сенсоневральных нарушений среди пациентов, посещающих районные и городские поликлиники. По результатам анкетирования у 34,4% пациентов выявлены данные, соответствующие субклиническим нарушениям слуховой функции, у 27,1% результаты трактовались как наличие тугоухости различной степени выраженности. Только 38,5% пациентов, которым был применен выбранный способ скринингового выявления первичных нарушений слуха, демонстрировали отсутствие данных за наличие у них тугоухости. Акцентированный анализ выявил наибольший процент пациентов с начальными и выраженными нарушениями слуха среди тех, кто имеет заболевания сердечно-сосудистой, эндокринной и нервной систем. Заключение. Выявлена целесообразность использования скринингового метода по обнаружению начальных форм сенсоневральной тугоухости у пациентов с хронической общесоматической патологией. Внедрение метода адаптированного анкетирования в практику семейных врачей, неврологов, эндокринологов у взрослых позволяет на доклиническом этапе определить группы риска среди пациентов, нуждающихся в проведении специализированной сурдологической помощи. Purpose. To evaluate results of an epidemiological screening study to identify initial forms of sensorineural hearing loss among patients with chronic somatic pathology in a particular region. Materials and methods. We used a method of hearing disorders screening diagnostics with a computer program SLUH-info, based on survey results of patients with no primary complaints of hearing impairment. The study involved 5604 patients with various forms of chronic somatic pathology. The survey was conducted anonymously. Results. The survey conducted based on a score assessment of the patient’s psychoemotional state in various auditory settings allowed to identify risk groups for the development of sensorineural disorders among patients attending district and city polyclinics. The results of the survey revealed data corresponding to subclinical disorders of auditory function in 34.4% of patients, and in 27.1% the results were interpreted as the presence of hearing loss of various degrees of severity. Only 38.5% of patients who underwent the selected method of screening for primary hearing disorders demonstrated no data indicating a hearing loss. An emphasis analysis revealed the highest percentage of patients with initial and pronounced hearing disorders among those with cardiovascular, endocrine, and nervous system diseases. Conclusion. The feasibility of using a screening method to detect initial forms of sensorineural hearing loss in patients with chronic general somatic pathology was revealed. The implementation of the adapted questionnaire method into the practice of family physicians, neurologists, and endocrinologists in adults allows the identification of risk groups among patients in need of specialized surdological care at the preclinical stage.

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“…Indeed, UCP2 deficiency is associated with mitochondrial abnormalities and is implicated in hearing loss. 38,48,60 A study comparing 83 patients suffering from sudden sensorineural hearing loss to 2,048 controls in a Japanese population showed a significant association between UCP2 polymorphisms and sensorineural hearing loss. 38 In a separate study, UCP2 (G-866 A) polymorphism was found to contribute significant risk to age-related hearing loss.…”

Section: Protecting Mitochondriamentioning

confidence: 99%

“…38,48,60 A study comparing 83 patients suffering from sudden sensorineural hearing loss to 2,048 controls in a Japanese population showed a significant association between UCP2 polymorphisms and sensorineural hearing loss. 38 In a separate study, UCP2 (G-866 A) polymorphism was found to contribute significant risk to age-related hearing loss. 48 Vegetable compounds (e.g., berberine, curcumin, and capsaicin) or pharmaceutical drugs (e.g., fenofibrate) are shown to induce UCP2 expression in a variety of cell types.…”

Section: Protecting Mitochondriamentioning

confidence: 99%

Approaches to Mitigate Mitochondrial Dysfunction in Sensorineural Hearing Loss

Okur

Djalilian

2022

Ann Biomed Eng

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Mitochondria are highly dynamic multifaceted organelles with various functions including cellular energy metabolism, reactive oxygen species (ROS) generation, calcium homeostasis, and apoptosis. Because of these diverse functions, mitochondria are key regulators of cell survival and death, and their dysfunction is implicated in numerous diseases, particularly neurodegenerative disorders such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease. One of the most common neurodegenerative disorders is sensorineural hearing loss (SNHL). SNHL primarily originates from the degenerative changes in the cochlea, which is the auditory portion of the inner ear. Many cochlear cells contain an abundance of mitochondria and are metabolically highly active, rendering them susceptible to mitochondrial dysfunction. Indeed, the causal role of mitochondrial dysfunction in SNHL progression is well established, and therefore, targeted for treatment. In this review, we aim to compile the emerging findings in the literature indicating the role of mitochondrial dysfunction in the progression of sensorineural hearing loss and highlight potential therapeutics targeting mitochondrial dysfunction for hearing loss treatment.

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Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss

Cited by 9 publications

References 25 publications

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

Epidemiological Studies to Detect Hearing Impairment in Adults with Chronic General Somatic Pathology

Approaches to Mitigate Mitochondrial Dysfunction in Sensorineural Hearing Loss

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