Association between urinary arsenic, blood cadmium, blood lead, and blood mercury levels and serum prostate-specific antigen in a population-based cohort of men in the United States

Wu, Hongke; Wang, Ming; Raman, Jay D.; McDonald, Alicia C.

doi:10.1371/journal.pone.0250744

Cited by 15 publications

(17 citation statements)

References 32 publications

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“…The PSA is mainly excreted from the normal epithelium of prostate tissue and its level rises slightly with age as the prostate gland grows bigger. However, a number of other factors can also affect PSA levels, including lifestyle and metal(loid) exposure [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, several of these metal(loid)s are recognized as endocrine disruptor chemicals (EDCs) [ 16 , 21 , 22 , 23 , 24 ] that interfere with estrogen and androgen signaling pathways affecting the expression of genes involved in the growth and the secretory function of the prostate gland and contributing to prostate carcinogenesis [ 25 , 26 ]. Although the scanty epidemiologic data available indicate a possible contribution of several individual metal(loid)s to an increased risk of prostate cancer, only a few studies investigated their contribution to the increased PSA levels in presumably healthy men [ 10 , 12 , 13 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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“…Sociodemographic variables included age (year), poverty to income ratio, race/ethnicity (Mexican American, other Hispanic, non-Hispanic white, non-Hispanic black, others), an education level (less than high school, high school, more than high school), marital status (married, single, living with a partner). Variables of laboratory data included blood urea nitrogen (mmol/L), uric acid (umol/L), creatinine (umol/L) (41,49,50). The LX20 modular chemistry (BUNm) and timed endpoint method were used to quantitatively determine the concentration of blood urea nitrogen and uric acid in serum or plasma.…”

Section: Other Variablesmentioning

confidence: 99%

“…In order to verify our hypothesis, we explored the U.S. National Health and Nutrition Examination Survey (NHANES) for secondary analysis. According to previous articles (38)(39)(40)(41)(42)(43), we controlled the potential confounders including, age, race, education level, marital status, poverty to income ratio, BMI, alcohol drinks, smoking, diabetes, physical activity, blood urea nitrogen, uric acid, creatinine which might be related to both the exposure as well as the outcome. Then we constructed models to clarify the comprehensive relationship between the volatile organic compounds (VOCs) and prostate-specific antigen (PSA).…”

Section: Introductionmentioning

confidence: 99%

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

Wei

Chen

Yang

et al. 2022

Front. Public Health

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BackgroundVolatile organic compounds (VOCs) are a large group of chemicals widely used in people's daily routines. Increasing evidence revealed the VOCs' accumulating toxicity. However, the VOCs toxicity in male prostate has not been reported previously. Thus, we comprehensively evaluated the association between VOCs and prostate-specific antigen (PSA).MethodsA total of 2016 subjects were included in our study from the National Health and Nutrition Examination Survey with VOCs, PSA, and other variables among U.S. average population. We constructed XGBoost Algorithm Model, Regression Model, and Generalized linear Model (GAM) to analyze the potential association. Stratified analysis was used to identify high-risk populations.ResultsXGBoost Algorithm model identified blood chloroform as the most critical variable in the PSA concentration. Regression analysis suggested that blood chloroform was a positive association with PSA, which showed that environmental chloroform exposure is an independent risk factor that may cause prostate gland changes [β, (95% CI), P = 0.007, (0.003, 0.011), 0.00019]. GAM observed the linear relationship between blood chloroform and PSA concentration. Meanwhile, blood chloroform linear correlated with water chloroform in the lower dose range, indicating that the absorption of water may be the primary origin of chloroform. Stratified associations analysis identified the high-risk group on the chloroform exposures.ConclusionThis study revealed that blood chloroform was positively and independently associated with total PSA level, suggesting that long-term environmental chloroform exposure may cause changes in the prostate gland.

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“…Toxicity from arsenic is currently a public health concern [8]. When arsenic is ingested, it causes skin hypo-pigmentation, peripheral vascular diseases such as black foot disease, gangrene, and high blood pressure [9].…”

Section: Introductionmentioning

confidence: 99%

Toxic heavy metals in the breast milk of diabetic and non-diabetic postpartum mothers in Yenagoa, Nigeria

Philip-Slaboh

Eleke

Ezejiofor

2022

Preprint

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Breast milk is considered to be the best substance for neonatal nutrition. It is not well known whether diabetes increases the expression of toxic heavy metals in the breast milk of postpartum mothers. This study compared the concentration of toxic heavy metals in breast milk between diabetic and non-diabetic postpartum mothers in Yenagoa. A cross-sectional design was utilized on a purposive sample of 144 consenting postpartum mothers (72 diabetic and 72 non-diabetic mothers) from one tertiary, one secondary, and one primary medical centre. Breast milk samples were collected at 5-6 weeks postpartum between 1st November 2020 and 30th April 2021. A spectrophotometer was used to analyze the breast milk samples. A pro forma was used for data extraction and data were analyzed at a 5% significance level. The Diabetes group had levels of Arsenic (63.9%), Lead (95.8%), Mercury (68.1%), and Cadmium (84.7%) above the WHO permissible limits. The mean concentrations were 0.6 ng/ml (Arsenic), 13.2ng/ml (Lead), 2.9ng/ml (Mercury), and 3.3ng/ml (Cadmium). The non-diabetic mothers also had high levels of Arsenic (62.5%), Lead (95.8%), Mercury (72.2%), and Cadmium (86.1%); and the mean concentrations were 0.6ng/ml (Arsenic), 12.2 ng/ml (Lead), 3.0ng/ml (Mercury), and 3.2ng/ml (Cadmium). There was no significant difference in the concentration of toxic heavy metals in breast milk between the diabetic and non-diabetic postpartum mothers (p = > 0.585). In conclusion, diabetes did not seem to increase the concentration of toxic heavy metals expressed in breast milk. More rigorous studies are needed to confirm these findings.

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Association between urinary arsenic, blood cadmium, blood lead, and blood mercury levels and serum prostate-specific antigen in a population-based cohort of men in the United States

Cited by 15 publications

References 32 publications

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001–2010

Toxic heavy metals in the breast milk of diabetic and non-diabetic postpartum mothers in Yenagoa, Nigeria

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