Association between Urinary Neurotransmitter Status and Scoliosis Progression: A Case-Controlled Series

Abstract

Previous investigations into the relationship between neurotransmitter abnormalities and idiopathic scoliosis have been mixed. The purpose of the present study was to evaluate the differences in a urinary neurotransmitter profile across three different groups. These groups included a progressive scoliosis group, a non-progressive scoliosis group, and a non-scoliotic control group. When evaluating urinary neurotransmitter levels across all groups, statistically significant differences were observed between all three groups for multiple neurotransmitters. The differences seemed to increase as the scoliosis increased in Cobb angle measurement. Further studies should seek to distinguish a potential cause or effect relationship between these neurotransmitter abnormalities and idiopathic scoliosis onset and/or progression.

Applying the Functional Medicine Model to Idiopathic Scoliosis Management: A Narrative Mini-Review

“…Other studies have demonstrated a link between frank serotonin deficiency and idiopathic scoliosis [22]. Multiple neurotransmitter levels differ among patients with idiopathic scoliosis when compared to their peers [23]. This is not a new concept [24].…”