Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Ji, Junjun; Song, Lingyan; Wang, Jing; Yang, Zhiyun; Yan, Haotian; T, Li; Li, Yu; Jian, Lingyu; Jiang, Feixiang; Li, Junfeng; Li, Kefeng

doi:10.1016/j.envint.2021.106524

Cited by 26 publications

(24 citation statements)

References 63 publications

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“…Connectome analysis could include more diverse age groups, especially adolescents. Additionally, the integration of results from different connectomes, including connectomes based on proteomics, metabolomics, transcriptomics and exposomics, may prove more informative than analyses based on a single connectome [ 149 , 150 ].…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

et al. 2021

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Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

et al. 2021

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“…These concentrations were 135, 35, and 5 times higher than those measured in the reference population from Karlshamn. To put these exposure levels into context, Ji et al [8] performed their study in a population with median serum…”

Section: Discussionmentioning

confidence: 99%

“…From a public health perspective, it is highly relevant to clarify whether PFAS also increases the susceptibility to SARS-CoV-2 because such knowledge would aid in identifying individuals at higher risk of infection. A recent case-control study of 160 participants from Shanxi and Shandong, Chinese provinces with both high PFAS exposure and high incidence of COVID-19, showed increased odds ratios of mild infection with increasing urine concentrations of PFOS, PFOA, and the sum of 12 PFAS [8]. Taken together, these studies provide some evidence that exposure to PFAS may indeed play a role in the clinical course of COVID-19, but further studies are needed to verify the findings.…”

Section: Introductionmentioning

confidence: 92%

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Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden

Nielsen

Jöud

2021

IJERPH

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There is concern that immunotoxic environmental contaminants, particularly perfluoroalkyl substances (PFAS), may play a role in the clinical course of COVID-19 and epidemiologic studies are needed to answer if high-exposed populations are especially vulnerable in light of the ongoing pandemic. The objective was, therefore, to determine if exposure to highly PFAS-contaminated drinking water was associated with an increased incidence of COVID-19 in Ronneby, Sweden, during the first year of the pandemic. We conducted an ecological study determining the sex- and age-standardized incidence ratio (SIR) in the adult population relative to a neighboring reference town with similar demographic characteristics but with only background levels of exposure. In Sweden, COVID-19 is subject to mandatory reporting, and we retrieved aggregated data on all verified cases until 3 March 2021 from the Public Health Agency of Sweden. The SIR in Ronneby was estimated at 1.19 (95% CI: 1.12; 1.27). The results suggest a potential link between high PFAS exposure and susceptibility to COVID-19 that warrants further research to clarify causality.

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“…Recently, a computational systems biology approach was used to study the relationship between EDCs and COVID-19 severity and identified the T-helper cell 17 (Th17) and the advanced glycation end products/receptor for advanced glycation end products (AGE/RAGE) pathways as principal targets through which EDCs could contribute to COVID-19 severity [20]. A non-mechanistic study that analyzed the urine and serum concentrations of Per-and poly-fluoroalkyl substances (PFASs) found a positive association between urinary levels of perfluorooctanesulfonic acid (PFOS) (odds ratio: 2.29 (95% CI: 1.52-3.22)), perfluorooctanoic acid (PFOA) (2.91, (1.95-4.83)), and total PFASs (Σ (12) PFASs) (3.31, (2.05-4.65)) with the risk of COVID-19 infection [137]. These preliminary studies provide insight into how EDCs can influence the clinical outcome of COVID-19 disease.…”

Section: Current Knowledge On Edcs and Covid-19 Risksmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to Immunosuppression

Adegoke

Rahman

Park

et al. 2021

IJMS

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Endocrine-disrupting chemicals (EDCs) are hormonally active compounds in the environment that interfere with the body’s endocrine system and consequently produce adverse health effects. Despite persistent public health concerns, EDCs remain important components of common consumer products, thus representing ubiquitous contaminants to humans. While scientific evidence confirmed their contribution to the severity of Influenza A virus (H1N1) in the animal model, their roles in susceptibility and clinical outcome of the coronavirus disease (COVID-19) cannot be underestimated. Since its emergence in late 2019, clinical reports on COVID-19 have confirmed that severe disease and death occur in persons aged ≥65 years and those with underlying comorbidities. Major comorbidities of COVID-19 include diabetes, obesity, cardiovascular disease, hypertension, cancer, and kidney and liver diseases. Meanwhile, long-term exposure to EDCs contributes significantly to the onset and progression of these comorbid diseases. Besides, EDCs play vital roles in the disruption of the body’s immune system. Here, we review the recent literature on the roles of EDCs in comorbidities contributing to COVID-19 mortality, impacts of EDCs on the immune system, and recent articles linking EDCs to COVID-19 risks. We also recommend methodologies that could be adopted to comprehensively study the role of EDCs in COVID-19 risk.

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Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Abstract: Graphical abstract

Cited by 26 publications

References 63 publications

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden

Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to Immunosuppression

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