Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Li, Tao; Wu, Changjing; Fu, Fudong; Qin, Feng; Wei, Qiang; Yuan, Jiuhong

doi:10.1097/md.0000000000011367

Cited by 11 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The constant NOS-NO-cGMP pathways were in accordance with ICP, AUC, and ICP/MAP indices, which verified that long-term aspirin administration had beneficial effects on erectile function. This was also consistent with previous clinical studies 2,3,18,39,40 .…”

Section: Discussionsupporting

confidence: 93%

Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

As the broad spectrum pharmacological action, aspirin has been one of the most widely used medicines since its initial synthesis; however, the association between aspirin and erectile function is still controversial. We aim to explore whether long-term aspirin administration deteriorates or preserves erectile function from adult rats and ageing rat model. Twenty adult rats (10 weeks of age) and twenty ageing rats (80 weeks of age) were randomly divided into four groups as follows: Adult-Control (normal saline [NS]), Adult-Aspirin (aspirin, 10 mg/kg/d), Ageing-Control (NS), and Ageing-Aspirin (aspirin, 10 mg/kg/d) groups (n = 10 per group). For all rats, erectile function was assessed by maximum intracavernous pressure (ICP), total area under ICP curve (AUC), ICP/mean arterial pressure (MAP) ratio, and MAP. The total treatment duration was one month. Protein expression levels of cyclooxygenase-1 (COX-1), COX-2, endothelial nitric oxide synthase (eNOS), and nNOS of the corpus cavernosum were detected by Western blot. ELISA kits were used to determine 6-keto PGF 1a , PGE 2 , TXB 2 , cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP) levels. Total nitric oxide (NO) concentration was measured using a fluorometric assay kit. As a result, Ageing-Control rats revealed significantly decreased ICP, AUC, and ICP/MAP ratios compared to Adult-Control rats, and these effects were accompanied by reduced eNOS protein expression and lower total NO and cGMP levels; however, no difference was found in nNOS protein expression. For adult rat groups, aspirin significantly inhibited the production of 6-keto PGF 1a , PGE 2 , and TXB 2 ; however, it neither changed the ICP, AUC, or ICP/ MAP ratios nor altered the protein expression of eNOS, nNOS, COX-1, and COX-2. Meanwhile, aspirin did not influence the concentrations of total NO, cAMP, or cGMP. The same tendency was also found in the ageing rat model, which confirmed that aspirin did not alter erectile function. Our data suggested that long-term aspirin administration did not strengthen or weaken erectile function in adult rats or ageing rat model. Thus, it had no impact on erectile function.

show abstract

Section: Discussionsupporting

confidence: 93%

Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, it might have a chance to be effective in reducing erectile dysfunction. Low-grade inflammation and high circulating pro-inflammatory markers occur during the vascular erectile dysfunction process . Maca may benefit the anti-inflammatory related diseases.…”

Section: Resultsmentioning

confidence: 99%

Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities

Purnomo

Korinek

Tsai

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Four active partition layers and ten isolates, including (5R)-and (5S)-macapyrrolidone A (1a, 1b), and four new alkaloids, (5R)-and (5S)-macapyrrolidone B (2a, 2b) and macapyrrolins D, E (3, 4), were isolated from maca (Lepidium meyenii Walp.), an indigenous food plant from Peru. Derived from the n-hexane layer, the macamide-rich fraction exhibited pro-angiogenic activity on EPC and HUVEC cells. Anti-thrombotic activity was displayed by the polar part of maca extracts (n-butanol and water layers). Both 75% methanol aq. (midlower polar part) and n-hexane (low polar part) layers, which showed signs of fatty acid content, markedly inhibited superoxide and elastase release in an anti-inflammatory assay. The 75% methanol aq. layer showed strong antiallergic activity, and macapyrrolin A (5) was found active based on β-hexosaminidase release inhibition assays and a ChemGPS-NP experiment. These valuable bioactivity results suggest that maca is a food plant with good benefits for human health.

show abstract

“…A recent systematic review reported contrasting results regarding the association between Aspirin and ED. [ 32 ] Some studies have identified a protective association of Aspirin by preserving impairment nitric oxide synthase and reducing hypercoagulability of blood flow in penile organs. On the other hand, a few studies concluded Aspirin as a risk factor because of their interference in the production of prostaglandin.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of erectile dysfunction and associated factors among males visiting family medicine clinics in a Tertiary Care Hospital in Karachi, Pakistan

Saeed

Amin

Durrani

et al. 2021

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

Background: The burden of erectile dysfunction (ED) among the developed countries is found to be quite high. However, there is a paucity of data among developing countries to know its actual burden and factors associated with it. Methods: The current study is cross-sectional and was conducted in Family Medicine clinics of Liaquat National Hospital during May 2017–January 2018. A total of 450 males participated in this study with the age range of 24–77 years. More than half of the participants were graduates or above. Results: On multivariable analysis, age (aOR = 5.47, 95% CI: 2.74–10.89), alcohol use (aOR = 5.23, 95% CI: 1.45–18.84), diabetes (aOR = 6.61, 95% CI: 3.27–13.36), and current smoking (OR = 2.41, 95% CI: 1.35–4.31) were significantly associated with ED. ED risk was significantly lower in those who either attended secondary school (aOR = 0.33, 95% CI: 0.13–0.88) or were at least graduates (aOR = 0.40, 95% CI: 0.17–0.96) than illiterate when model was adjusted for other covariates. Conclusion: Erectile dysfunction in a Pakistani male population highlights the need for routine screening at the primary care level. There is a possibility that the actual burden is underreported due to cultural stigmatization; hence, further research is warranted to validate the findings.

show abstract

Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction

Cited by 11 publications

References 40 publications

Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model

Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model

Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities

Prevalence of erectile dysfunction and associated factors among males visiting family medicine clinics in a Tertiary Care Hospital in Karachi, Pakistan

Contact Info

Product

Resources

About