Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients

Šerý, Omar; Šťastný, F; Zvolský, P; Hlinomazová, Zuzana; Balcar, Vladimír J.

doi:10.1016/j.neulet.2011.05.038

Cited by 15 publications

(13 citation statements)

References 24 publications

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“…Two studies had been carried out within different ethnic groups [17] or different drugs [11]. After classification of these two studies into five subgroups, the number of studies was raised to 23. n Study characteristics [11,19,25,29], substance (5%) [24], nicotine (14%) [14,15,26] and alcohol (31%) [13,18,[20][21][22][23]27,30].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 23 studies, 59% were from Asia [11][12][13]17,19,[20][21][22]. Studies from China [19,23,25.26] and one study from Taiwan [29] were carried out in the Han Chinese population, while other reports from Taiwan did not identify the ethnic subgroup of the participants.…”

Section: Resultsmentioning

confidence: 99%

“…Subgroup metaanalyses were conducted in order to evaluate the overall effects in the subgroups according to Asian and Caucasian ethnicity in each addiction type. Sensitivity analyses were carried out by excluding studies to assess their influence Tsai et al [22] Su et al Review Haerian on the overall effect sizes. The Bonferroni correction was used in order to compare multiple studies and their subgroups.…”

Section: Methodsmentioning

confidence: 99%

“…The impact of this polymorphism has been widely studied in a variety of psychiatric diseases and drug addictions. Some studies conducted in the past have suggested a possible association of the rs6265 polymorphism with addiction to drugs, but the data have been inconsistent (Table 1) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. In order to more precisely evaluate the association between this polymorphism and the risk of drug dependence, a systematic review and meta-analysis of published case-control studies was conducted.…”

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confidence: 99%

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BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

Haerian

2013

Pharmacogenomics

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A majority of studies have shown a link between the common functional rs6265 polymorphism of the BDNF gene and susceptibility to drug dependence. However, the pattern of results is inconsistent. To precisely evaluate this association, a systematic review and meta-analysis of previous case-control reports was conducted. Data from 20 studies containing 9419 participants (4665 cases and 4754 controls) conducted between 2004 and 2013 restricted to alcohol, nicotine, heroin, substance and methamphetamine dependency were meta-analyzed. Following quality control of the results, a significant association between C allele and methamphetamine dependence remained in south Asian subjects (p = 0.004). Similar results were detected in south Asian subjects for methamphetamine dependence and in Chinese subjects for heroin dependence under an autosomal codominant genotype model (TT vs CC, p = 0.005 and p = 0.0004, respectively). In conclusion, the rs6265 polymorphism may be a risk factor for methamphetamine dependence in south Asian subjects or for heroin dependence in Chinese subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

Haerian

2013

Pharmacogenomics

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“…The GLAST upregulation would result in a more rapid clearance of L-Glu and this mechanism in concert with the concommitant increase in glutamine synthase which catabolises any accumulated glutamate, could contribute to the neuroprotective effects of BDNF [93]. Furthermore, the BDNF effect on EAAT1/GLAST expression might explain results of an association study which uncovered a relationship between 66Met allele of BDNF (that is associated with an increased BDNF expression) and protection of patients with alcoholism from colour vision deficiency induced by long-term excessive alcohol intake and thought to be linked to an increased NMDA receptor density [94].…”

Section: Epigenetics and Transcription Regulation Of Eaatsmentioning

confidence: 99%

GLAST But Not Least—Distribution, Function, Genetics and Epigenetics of l-Glutamate Transport in Brain—Focus on GLAST/EAAT1

et al. 2015

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Synaptically released L-glutamate, the most important excitatory neurotransmitter in the CNS, is removed from extracellular space by fast and efficient transport mediated by several transporters; the most abundant ones are EAAT1/GLAST and EAAT2/GLT1. The review first summarizes their location, functions and basic characteristics. We then look at genetics and epigenetics of EAAT1/GLAST and EAAT2/GLT1 and perform in silico analyses of their promoter regions. There is one CpG island in SLC1A2 (EAAT2/GLT1) gene and none in SLC1A3 (EAAT1/GLAST) suggesting that DNA methylation is not the most important epigenetic mechanism regulating EAAT1/GLAST levels in brain. There are targets for specific miRNA in SLC1A2 (EAAT2/GLT1) gene. We also note that while defects in EAAT2/GLT1 have been associated with various pathological states including chronic neurodegenerative diseases, very little is known on possible contributions of defective or dysfunctional EAAT1/GLAST to any specific brain disease. Finally, we review evidence of EAAT1/GLAST involvement in mechanisms of brain response to alcoholism and present some preliminary data showing that ethanol, at concentrations which may be reached following heavy drinking, can have an effect on the distribution of EAAT1/GLAST in cultured astrocytes; the effect is blocked by baclofen, a GABA-B receptor agonist and a drug potentially useful in the treatment of alcoholism. We argue that more research effort should be focused on EAAT1/GLAST, particularly in relation to alcoholism and drug addiction.

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Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

Marrero-Cristobal

Gelpi-Dominguez

Morales-Silva

et al. 2021

J of Neuroscience Research

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Substance use disorder (SUD) is a complex condition that involves the induction of molecular and physiological alterations by the use and abuse of illicit substances. The prevalence of illicit drug use has caused this disorder to grow exponentially over the past 5 years (National Institute of Drug Abuse, 2020). To date, there are several FDA-approved pharmacological treatments for substances that may cause dependency, such as heroin, morphine, alcohol, and nicotine, directed to the attenuation of drug craving, and increase time to relapse. Known as medication-assisted treatment, such FDA-approved pharmaceutical interventions can be used to increase the effectiveness of other substance abuse treatments, including the use of buprenorphine (commonly used in opioid use disorder, OUD).Buprenorphine works as a partial agonist that binds to the opioid receptors in the brain, allowing a partial activation of the receptor when it is activated with opioids, and thus reducing the rewarding effects (James & Williams, 2020). Another FDA-approved treatment for OUD is naloxone, a known opioid receptor antagonist that reduces activation and prevents other endogenous ligands to bind to that receptor (Becker & Chartoff, 2019;James & Williams, 2020). These types of pharmacological treatments are still not available for substances such as cocaine, methamphetamines, or cannabis which limit treatment options. The percentage cocaine users aged

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Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients

Cited by 15 publications

References 24 publications

BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

BDNF rs6265 Polymorphism and Drug Addiction: a Systematic Review and Meta-Analysis

GLAST But Not Least—Distribution, Function, Genetics and Epigenetics of l-Glutamate Transport in Brain—Focus on GLAST/EAAT1

Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

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