Association between variants on the vitamin D Receptor gene and chronic kidney disease among a Yoruba population in Ibadan, Nigeria

Olajide, Taiwo H.; Raji, Yemi Raheem; Ademola, Subulade A.; Dele-Alimi, Temiloluwa; Oluwaseye, Abimbola; Ayomide, Ojetola; Ajani, Halimah O.; Abdulkareem, Mutiat A.; Amodu, Olukemi K.

doi:10.1016/j.humgen.2023.201146

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…There are several SNPs that can be detected in the VDR sequence region such as rs2228570 (FokI), located in exon 2, rs7975232 (ApaI), and rs757343 (Tru9I), located in intron 8, that are included in the study. These polymorphisms produce two types of alleles that differ based on the presence or lack of the restriction site, which may be detected by RFLP ( Olajide et al, 2023 ). Many studies have been carried out to determine whether there are genetic variations in a specific region of the vitamin D receptor (VDR) linked to hematological malignancies.…”

Section: Introductionmentioning

confidence: 99%

The impact of circulating 25-hydroxyvitamin D and vitamin D receptor variation on leukemia-lymphoma outcome: Molecular and cytogenetic study

Abdulrazaq,

Al-Ouqaili,

Talib

2024

Saudi Journal of Biological Sciences

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Section: Introductionmentioning

confidence: 99%

The impact of circulating 25-hydroxyvitamin D and vitamin D receptor variation on leukemia-lymphoma outcome: Molecular and cytogenetic study

Abdulrazaq,

Al-Ouqaili,

Talib

2024

Saudi Journal of Biological Sciences

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Investigating the Association of TaqI (rs731236), ApaI (rs7975232), and BsmI (rs1544410) With Diabetic Nephropathy: A Case for Broader Genetic and Epigenetic Research

Siham

2024

J Diabetol

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Study of Association of Vitamin D Receptor Gene Polymorphisms with Diabetic Nephropathy

Esha,

Yogaprabhu,

Sneha

et al. 2024

JODB

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Background: Type 2 diabetes leads to many microvascular complications, including diabetic nephropathy, also referred to as diabetic kidney disease. Vitamin D deficiency may play a role in the development of type 2 diabetes and nephropathy. The functions of vitamin D are mediated through vitamin D receptor (VDR). Three single nucleotide polymorphisms (SNPs) in VDR gene, namely, TaqI (rs731236), ApaI (rs7975232), and BsmI (rs1544410), have been widely studied in association with diabetes and nephropathy. The objective of this study was to investigate the association of these VDR gene SNPs with nephropathy in the South Indian population. Additionally, the effect of VDR gene variants on vitamin D levels was also investigated. Subjects and Methods: Two hundred forty-eight individuals with type 2 diabetes without nephropathy (T2DM) and 399 individuals with type 2 diabetes with nephropathy (T2DN) were genotyped for this study. Genotyping of TaqI was performed using the polymerase chain reaction-restriction fragment length polymorphism method. BsmI and ApaI were genotyped using MassArray. Anthropometric and biochemical data were collected for all participants. Vitamin D levels were measured in a subset of 47 T2DM and 74 T2DN individuals. Statistical analysis was performed using Statistical Package for the Social Sciences version 21.0 (IBM Corporation, Armonk, NY). Results: The genotype and minor allele frequencies of TaqI, BsmI, and ApaI were not significantly different between T2DM and T2DN groups. However, vitamin D levels were significantly reduced in T2DN (15.5 ± 1.16 ng/ml) compared to T2DM (20.5 ± 2.11 ng/ml, P = 0.027). No significant differences were found in the vitamin D levels when the T2DM and T2DN groups were stratified based on TaqI, BsmI, and ApaI genotypes. Conclusion: This study did not find a significant association of VDR SNPs (TaqI, BsmI, and ApaI) with T2DN. However, the study suggested a protective role of vitamin D levels in T2DN.

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Association between variants on the vitamin D Receptor gene and chronic kidney disease among a Yoruba population in Ibadan, Nigeria

Cited by 3 publications

References 30 publications

The impact of circulating 25-hydroxyvitamin D and vitamin D receptor variation on leukemia-lymphoma outcome: Molecular and cytogenetic study

The impact of circulating 25-hydroxyvitamin D and vitamin D receptor variation on leukemia-lymphoma outcome: Molecular and cytogenetic study

Investigating the Association of TaqI (rs731236), ApaI (rs7975232), and BsmI (rs1544410) With Diabetic Nephropathy: A Case for Broader Genetic and Epigenetic Research

Study of Association of Vitamin D Receptor Gene Polymorphisms with Diabetic Nephropathy

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