Association between vasectomy and risk of testicular cancer: A systematic review and meta-analysis

Duan, Haifeng; Deng, Tuo; Chen, Yiwen; Zhao, Zhijian; Wen, Yuan; Chen, Yeda; Li, Xiaohang; Zeng, Guohua

doi:10.1371/journal.pone.0194606

Cited by 19 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The quality of observational studies was determined using the Newcastle-Ottawa Scale. Any study that scored over seven stars was regarded as a high-quality study, while a score of four to six stars was regarded as a moderate-quality study ( 33 ). A quality assessment of the RCTs was carried out using the Cochrane risk of bias tool ( Figures 2 , 3 ).…”

Section: Resultsmentioning

confidence: 99%

Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis

Liu

Ma²,

Sun³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to assess the efficacy and safety of adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) in patients with locally advanced cervical cancer (LACC) via meta-analysis.MethodsA systematic literature search of MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials was conducted from January 10, 1966 to May 20, 2022. Randomized controlled trials and observational studies comparing the CCRT alone with CCRT plus ACT were included. The literature search, quality assessment, and data extraction were conducted by two reviewers independently. The primary endpoints were 3-year rates of overall survival (OS) and progression-free survival (PFS). Complete response rate, local recurrence, distant metastasis, and adverse events were secondary outcomes. The hazard ratios (HRs) and relative risk (RR) were pooled.ResultsNine studies with a total of 2732 patients were included in this meta-analysis, including 1411 patients in the CCRT group and 1321 in the CCRT plus ACT group. The HR for 3-year rates of OS and PFS of the CCRT group compared with the CCRT plus ACT group was 0.72 [95%confidence interval (CI) = 0.44–1.17] and 0.78 (95%CI = 0.5–1.75), respectively. No significant differences were observed between the two groups in the complete response rate (RR = 1.06, 95%CI = 0.96–1.16). However, local recurrence and distant metastasis were significantly lower in the CCRT plus ACT group than in the CCRT group (RR = 0.63, 95%CI = 0.44 –0.91 and RR = 0.64, 95%CI = 0.47–0.88). Grade 3–4 acute toxicities were more frequent in the CCRT plus ACT group (RR = 1.73, 95%CI =1.19–2.52).ConclusionAlthough associated with a decreased risk of local recurrence and distant metastasis, ACT did not significantly improve the survival rate and the complete response rate with increasing grade 3–4 acute toxicities in patients with LACC. Thus, this ACT regimen cannot be recommended for patients with LACC.Systematic review registrationhttps://inplasy.com/inplasy-2022-9-0089/, identifier INPLASY202290089.

show abstract

Section: Resultsmentioning

confidence: 99%

Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis

Liu

Ma²,

Sun³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Two investigators (YL and DDL) extracted data independently using a predesigned data extraction form. The Newcastle-Ottawa quality assessment scale (NOS) was applied to evaluate the quality of the included observational studies [ 23 ]. The checklist contains three quality parameters: selected population, comparability of groups, and evaluation of exposures (for case-control) or outcomes (for cohorts) of interest [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…Each study was scored on a scale of 0 to 9. Studies with scores greater than or equal to 7 are generally considered to be of high quality [ 23 ]. The quality of each MR study was assessed independently by two investigators (YL and DDL) based on accepted criteria as previously reported [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk

Lü

Wang

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: Increasingly, studies have discovered that different fatty acids (Fas) are linked to colorectal cancer (CRC) risk. Methods: We systematically searched Embase and Medline databases to identify eligible studies that examined the associations of different types of Fas with CRC risk. The effect estimates and their 95% confidence intervals (Cis) were pooled using a random-effects model. Subgroup and sensitivity analyses were performed to examine the robustness of the study findings. Results: This study evaluated the associations of 28 dietary and 18 blood Fas with CRC risk by summarizing the most updated evidence from 54 observational and four Mendelian Randomization (MR) studies. The present findings suggested that high dietary intake of eicosapentaenoic acid (EPA), docosahexanoic acid (DHA), and docosapentaenoic acid (DPA) are related to low risk of CRC, while the n-6/n-3 PUFA ratio and trans-FA are related to high risk of CRC. The summary of all cohort studies found that a high intake of SFA and DHA was a protective factor for CRC, and a high intake of the n-6/n-3 PUFA ratio was a risk factor for CRC. In the subgroup analysis of cancer subsites, we found that the dietary intake of linoleic acid (LA) and trans-FA are risk factors, while DPA is a protective factor for colon cancer. High dietary DHA intake was associated with a lower risk of rectal cancer, while the dietary n-6/n-3 PUFA ratio was associated with a higher risk of rectal cancer. Meta-analysis of blood FA levels showed a significant reverse association between blood pentadecanoic acid and CRC risk, whilst other blood Fas showed no significant association with CRC risk. All included MR studies showed that high plasma arachidonic acid (AA) is associated with increased CRC risk. Conclusions: Current evidence on the dietary intake and blood levels of Fas in relation to CRC risk is less consistent. Future studies are needed to investigate how the metabolism of Fas contributes to CRC development.

show abstract

“…Two investigators (DL and YL) extracted data independently using a predesigned data extraction form. The quality of individual studies was assessed by the Newcastle-Ottawa Scale (NOS) for observational studies ( 27 ).…”

Section: Methodsmentioning

confidence: 99%

Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

Yuan

et al. 2022

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Background Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO levels are linked to a wide range of health outcomes. Objectives This study aimed to summarize health outcomes related to circulating TMAO levels. Methods We searched Embase, Medline, Web of Science and Scopus databases from inception to 15 February 2022 to identify and update meta-analyses examining the associations between TMAO and multiple health outcomes. For each health outcome, we estimated the summary effect size, 95% prediction confidence interval (CI), between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations. Results This umbrella review identified 24 meta-analyses that investigated the association between circulating TMAO levels and health outcomes including all-cause mortality, cardiovascular diseases, diabetes mellitus, cancer, and renal function. We updated these meta-analyses by including a total of 82 individual studies in 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found six (33%) associations (i.e., all-cause mortality, cardiovascular disease mortality, major adverse cardiovascular events, hypertension, diabetes mellitus, and glomerular filtration rate) to present highly suggestive evidence. Conclusions TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension, cardiovascular disease, diabetes, cancer and kidney function. Further studies are needed to investigate whether circulating TMAO levels could be an intervention target for chronic disease.

show abstract

Association between vasectomy and risk of testicular cancer: A systematic review and meta-analysis

Cited by 19 publications

References 22 publications

Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis

Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis

Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk

Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

Contact Info

Product

Resources

About