Association between VEGF −634G/C polymorphism and susceptibility to autoimmune diseases: A meta-analysis

Chen, Haikui; Zhang, Tianyun; Gong, Bolin; Cao, Xiaohong

doi:10.1016/j.gene.2015.01.023

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Moreover, Chen et al, who studied a sample of 413 hospital-based RA patients of Caucasian origin, reported that the T allele at VEGF rs3025039 could influence the onset of RA [ 21 ]. Additionally, a previous meta-analysis, which studied a total of 24 independent studies associated with autoimmune disease, revealed that VEGF polymorphisms were related to the susceptibility to RA [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

VEGF Gene Polymorphisms Affect Serum Protein Levels and Alter Disease Activity and Synovial Lesions in Rheumatoid Arthritis

et al. 2016

Med Sci Monit

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BackgroundOur study investigated 2 common single-nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) for their influences on serum VEGF levels, disease activity, and synovial lesions in rheumatoid arthritis (RA).Material/MethodsClinical information and venous blood samples were collected from 98 RA patients and 100 healthy controls. Genotyping on samples from the subjects was performed using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Serum VEGF levels were determined using the enzyme-linked immunosorbent assay (ELISA). The synovial thickness and joint effusion of 28 joints were measured in RA patients, and total sharp score (TSS) and disease activity score (DAS) of 28 joints were recorded.ResultsThe genotype and allele frequencies of VEGF rs833070 (G>A) and rs3025030 (G>C) were significantly different between RA group and control group (all P<0.05). VEGF rs833070 and rs3025030 polymorphisms were associated with increasing VEGF serum levels in the RA group (all P<0.01). Statistically significant difference was observed in DAS28 between the different genotypes of VEGF rs833070 in RA patients (P<0.05). Importantly, significant differences in synovial thickening, joint effusion and synovial angiogenesis were observed between the different genotypes of VEGF rs833070 and rs3025030 polymorphisms (all P<0.05).ConclusionsOur study provides evidence that VEGF polymorphisms might be important indicators of disease activity and synovial lesions, and prognostic factors in evaluating the treatment effectiveness in RA.

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Section: Discussionmentioning

confidence: 99%

VEGF Gene Polymorphisms Affect Serum Protein Levels and Alter Disease Activity and Synovial Lesions in Rheumatoid Arthritis

et al. 2016

Med Sci Monit

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“…Three meta‐analyses investigating the association between autoimmune diseases and VEGF polymorphism have concluded that there is a relationship between + 405G/C polymorphism in VEGF and susceptibility to immune‐mediated inflammatory diseases (Che et al, ; Chen et al, ; Wei et al, ). In this study, we speculated that vitiligo may imitate other autoimmune disorders by sharing some of the susceptibility genes and polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

“…it has been proved to be related to the development of many autoimmune disorders (Che, Li, Liu, Pan, & Liu, 2015;Chen, Zhang, Gong, & Cao, 2015). Moreover, a significant increase in the number of VEGF positive dermal vessels and marked dilatation of the blood vessels has been detected in the centre of vitiligo lesions compared to the periphery (Aroni et al, 2010;Stylianos, Eleftherios, Nikolaos, & Kyriaki, 2012).…”

Section: Introductionmentioning

confidence: 98%

“…Angiogenesis is controlled by various pro‐angiogenic and anti‐angiogenic factors. Vascular endothelial growth factor (VEGF) is the most potent pro‐angiogenic factor involved in this process (Sadick, Naim, Gössler, Hörmann, & Riedel, ; Shahidi‐Dadras et al, ) and by cooperating in the pathway of immunity; it has been proved to be related to the development of many autoimmune disorders (Che, Li, Liu, Pan, & Liu, ; Chen, Zhang, Gong, & Cao, ). Moreover, a significant increase in the number of VEGF positive dermal vessels and marked dilatation of the blood vessels has been detected in the centre of vitiligo lesions compared to the periphery (Aroni et al, ; Stylianos, Eleftherios, Nikolaos, & Kyriaki, ).…”

Section: Introductionmentioning

confidence: 99%

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Is the +405 G/C single nucleotide polymorphism of the vascular endothelial growth factor (VEGF) gene associated with late‐onset vitiligo?

Almasi‐Nasrabadi

Amoli

Robati

et al. 2019

Int J Immunogenetics

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The increasing body of evidence for the relationship between the vascular endothelial growth factor (VEGF) polymorphism and autoimmune disorders combined with the enhanced expression of this angiogenic factor in vitiligo makes VEGF a very interesting candidate gene to be investigated in vitiligo. The aim of this study was to evaluate the possible associations between the +405 G/C single nucleotide polymorphisms (SNP) of the VEGF gene (rs2010963) and vitiligo. The independent case–control population sample of 152 patients with vitiligo and 152 matched controls was evaluated in this study. A questionnaire was completed for each vitiligo patient to document the demographic and clinical characteristics of the patients. All enrolled individuals had a venous blood sample collected. Genotype frequencies for +405 G/C VEGF gene polymorphism were determined using polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism (RFLP) analysis. There were no significant differences in genotype or allele distributions for this SNP between cases and controls. However, we observed a significant association between GG genotype and higher age at onset of vitiligo (p = 0.04). Moreover, patients stratification revealed a significant increase in the frequency of GG genotype compared to CC + CG genotypes in patients with the late onset (≥20 years) vitiligo (p = 0.05). Although these results are not conclusive, they could potentially lead to considering the angiogenic factors as a potential target for therapy in late‐onset vitiligo.

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“…The +936 TT genotype may be an important biomarker for the prediction of IS recovery in Chinese patients. Recently, some promoter polymorphisms in the region of VEGFA , such as -2578 C > A , -1154 G > A and -634 C > G , have been reported to affect the susceptibilities and outcomes of many common diseases [ 51 – 53 ]. Therefore, further studies are needed to investigate whether these polymorphisms and their combined effect influence VEGF expression and IS outcome.…”

Section: Discussionmentioning

confidence: 99%

A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

et al. 2017

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Vascular endothelial growth factor (VEGF) plays critical roles in angiogenesis and vasculogenesis, which are associated with post-stroke functional recovery. However, the effects of the VEGFA polymorphisms on the outcome of ischemic stroke (IS) have been rarely reported. We therefore investigated the associations of +936C/T variant (rs3025039) with the susceptibilities and the 90-day outcomes from 494 IS patients and 337 healthy controls in Chinese population through the establishment of logistic multivariate regression model. Stroke severity at admission and outcome of 90 days were respectively assessed according to the National Institutes of Health Stroke Scale and the modified Rankin Scale. The analysis showed that there were no significant associations of the rs3025039 genotypes with the susceptibility (P = 0.229) and the severity (P = 0.734). However, when we divided the 308 IS patients into two groups according to the different outcomes, we found that the rs3025039 TC+TT genotype significantly increased the risk of poor recovery [adjusted odds ratio (OR), 1.99; 95% confidence interval (CI), 1.18–3.37]. Interestingly, we observed another 3ˈUTR variant, +1451C/T (rs3025040), exhibited strong linkage disequilibrium (r2 = 1.0) with +936C/T and was located in a predicted microRNA-binding site. The rs3025040 T allele significantly decreased the luciferase activities in four cell lines, which indicated a potential disruption of the miRNA-mRNA interaction that would result in lower VEGF expression levels. Our data suggested that the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site.

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Association between VEGF −634G/C polymorphism and susceptibility to autoimmune diseases: A meta-analysis

Cited by 7 publications

References 44 publications

VEGF Gene Polymorphisms Affect Serum Protein Levels and Alter Disease Activity and Synovial Lesions in Rheumatoid Arthritis

VEGF Gene Polymorphisms Affect Serum Protein Levels and Alter Disease Activity and Synovial Lesions in Rheumatoid Arthritis

Is the +405 G/C single nucleotide polymorphism of the vascular endothelial growth factor (VEGF) gene associated with late‐onset vitiligo?

A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

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