Association between ventricular premature contraction burden and ventricular repolarization duration

Söylemez, Nihat; Yaman, Belma

doi:10.1590/1806-9282.20220676

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Soylemez, Yaman manifestó que el intervalo Tp-Te y la relación Tp-Te/QT se prolongaron de manera estadísticamente significativa en el grupo de carga de contracción ventricular prematura que en el grupo control (85,3 +/-13,9 vs. 65,7 +/-11,9, p<0,001; 0,19 +/-0,03 frente a 0,15 +/-0,02, p<0,001, respectivamente). El ángulo QRS-T fue anormal de manera estadísticamente significativa en el grupo de carga de contracción ventricular prematura (p = 0,024) (20) .…”

Section: Discussionunclassified

Contracciones ventriculares prematuras: caso clínico

Arcentales Ortiz,

Mendoza Rivas,

Jaya Vásquez

2023

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Introducción. Las contracciones ventriculares prematuras son latidos adicionales que comienzan en una de las dos cavidades (ventrículos) inferiores de bombeo del corazón. Lo que causa una alteración del ritmo cardíaco regular. Objetivo. analizar el tratamiento aplicando un plan de atención de enfermería de las contracciones ventriculares prematuras, mediante la exposición de un caso clínico. Metodología. Análisis de caso clínico descriptiva, retrospectivo. La técnica empleada para la recolección de la información fue mediante la revisión de historia clínica y para respaldar el contexto teórico se apoyó de bases como Web of science, ProQuest, Pubmed, Scopus. Resultados. En el caso clínico expuesto se presenta a un paciente de 65 años de edad, sexo masculino con un ritmo sinusal /F.C. 60 LPM / PR 160 MS/ QRS 100 S / QT 340 MS / EJE -20º. Alteración de la contractilidad del ventrículo izquierdo, cavidades cardiacas de diámetros normales, función sistólica biventricular limite FEVI 50%, aparatos valvulares morfológica y funcionalmente normales. Con diagnósticos de trastorno del ritmo tipo extrasistoles ventriculares y supraventriculares aisladas. Conclusión. Las contracciones ventriculares prematuras son latidos adicionales que comienzan en una de las dos cavidades (ventrículos) inferiores de bombeo del corazón. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos / Clinical cases.

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Section: Discussionunclassified

Contracciones ventriculares prematuras: caso clínico

Arcentales Ortiz,

Mendoza Rivas,

Jaya Vásquez

2023

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“…In patients with LV systolic dysfunction and an implanted ICD, Tpe independently predicted ventricular tachyarrhythmia, appropriate ICD therapy, and overall mortality [34,35]. In recent studies, Tp-e interval prolongation was associated with higher PVC burden in patients with structurally normal hearts, and the Tp-e interval has been shown to be helpful in predicting sustained idiopathic VT in patients with idiopathic PVC [36,37]. Since one of the re-entry requirements is the local distribution of myocardial repolarization, it is reasonable to expect that an increase in the total ventricular distribution of repolarization (DVR) may predispose patients to ventricular tachyarrhythmias and cardiac arrest.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy

Baskan,

Karaca Ozer,

Orta

et al. 2023

Diagnostics

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The most common cause of death in patients with Duchenne muscular dystrophy (DMD) is cardiomyopathy. Our aim was to investigate the relationship between the Tpeak–Tend (Tp-e) interval and the premature ventricular contraction (PVC) burden and therefore early arrhythmic risk and cardiac involvement in DMD patients. Twenty-five patients with DMD followed by pediatric cardiology were included in the study. Those with a frequency of <1% PVC in the 24 h Holter were assigned to Group 1 (n = 15), and those with >1% were assigned to Group 2 (n = 10). Comparisons were made with healthy controls (n = 27). Left ventricular ejection fraction (LVEF) was lowest in Group 2 and highest in the control group (p < 0.001). LV end-diastolic diameter was greater in Group 2 than in Group 1 and the control group (p = 0.005). Pro-BNP and troponin levels were higher in Group 1 and Group 2 than in the control group (p = 0.001 and p < 0.001, respectively). Tp-e interval was longer in Group 2 compared to Group 1 and the control group (p < 0.001). The LVEF (OR 0.879, 95% CI 0.812–0.953; p = 0.002) and Tp-e interval (OR 1.181, 95% CI 1.047–1.332; p = 0.007) were independent predictors of PVC/24 h frequency of >1%. A Tp-e interval > 71.65 ms predicts PVC > 1%, with a sensitivity of 80% and a specificity of 90% (AUC = 0.842, 95% CI (0.663–1.000), p = 0.001). Determination of Tp-e prolongation from ECG data may help in the determination of cardiac involvement and early diagnosis of arrhythmic risk in DMD.

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Knock-inKcnh2Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death

Singh,

Wagner,

Williams

et al. 2024

Preprint

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BackgroundLong QT Syndrome Type-2 (LQT2) is due to loss-of-functionKCNH2variants.KCNH2encodes Kv11.1 that forms a delayed-rectifier potassium channel in the brain and heart. LQT2 is associated with arrhythmias, seizures, sudden cardiac death, and sudden unexpected death in epilepsy (SUDEP). The goal of the study is to develop a translational model that reproduces the neuro-cardiac electrical abnormalities and sudden death seen in people with LQT2.MethodsWe generated the first knock-in rabbit model of LQT2 (Kcnh2(+/7bp-del)), due to a 7 base-pair (7bp) deletion in the pore domain of the endogenous rabbitKcnh2gene.ResultsMutantKcnh2is expressed in the heart and brain and constitutes 11% of totalKcnh2inKcnh2(+/7bp-del)rabbits. TotalKcnh2, WTKcnh2, and WT Kv11.1 expression is lower inKcnh2(+/7bp-del)vs. WT rabbits.Kcnh2(+/7bp-del)rabbits exhibit prolonged cardiac ventricular repolarization (QTc, JTec, JTpc). There is an increased prevalence of spontaneous epileptiform activity and clinical seizures inKcnh2(+/7bp-del)(7 of 37 rabbits) vs. WT rabbits (1:68 rabbits,p<0.003). 18.9% ofKcnh2(+/7bp-del)vs. 1.5% of WT rabbits died suddenly and spontaneously (p<0.003). We recorded 2 spontaneous lethal events inKcnh2(+/7bp-del)rabbits: (1) sudden cardiac death and (2) seizure-mediated sudden death due to generalized tonic-clonic seizures, post-ictal generalized EEG suppression, bradycardia, ECG-T-wave inversion, focal cardiac activity, and asystole/death.ConclusionsWe developed the first genetic rabbit model of LQT2 that reproduces the cardiac and epileptic phenotypes seen in people with LQT2.Kcnh2(+/7bp-del)rabbits provide a valuable tool for future mechanistic studies, development of neurotherapeutics, and cardiac-safety testing.

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Association between ventricular premature contraction burden and ventricular repolarization duration

Cited by 3 publications

References 24 publications

Contracciones ventriculares prematuras: caso clínico

Contracciones ventriculares prematuras: caso clínico

Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy

Knock-inKcnh2Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death

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