Association between visual function and the integrity of residual ellipsoid zone in resolved central serous chorioretinopathy

Fujita, Asahi; Aoyama, Yurika; Tsuneyoshi, Saori; Sugiura, Aya; Azuma, Keiko; Asano-Shimizu, Kimiko; Soga, Hirotsugu; Hashimoto, Yukihiko; Asaoka, Ryo; Inoue, Tatsuya; Obata, Ryo

doi:10.1038/s41598-019-48825-7

“…The retinal sensitivity was significantly higher in the continuous group than the other two groups ( P = 0.01 Mann-Whitney U test). The improvements of the retinal sensitivity were associated with an improvement in the integrity of the EZ [ 40 , 44 ]. We were not able to detect the IZ consistently in all our patients posttreatment, and thus cannot determine if there was a change in the IZ posttreatment.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Iwase

¹

,

Yokouchi

²

,

Kitahashi

³

et al. 2020

BioMed Research International

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The purpose of this study was to evaluate the long-term effects of half-time photodynamic therapy (PDT) on the retinal sensitivity in eyes with chronic central serous chorioretinopathy (CSC). Twenty-two eyes of 22 patients with chronic CSC were studied. PDT was applied with full-dose verteporfin and half-time laser duration. The best-corrected visual acuity (BCVA) and retinal sensitivity in the central 2 and 10 degrees were evaluated at the baseline, and at 12 and 24 months after the half-time PDT. The retinal sensitivity was determined by Macular Integrity Assessment microperimetry (MAIA, Centervue, Padova, Italy). The results showed that the mean retinal sensitivities in the central 2 and 10 degrees were significantly improved at 12 months (25.6±2.79 dB, median; 26.11 dB, 25.6±2.25 dB, median; 25.65 dB, respectively; P<0.001) and at 24 months (26.3±2.62 dB, median; 27.38 dB, 26.6±2.21 dB, median; 27.45 dB, respectively; P<0.001) after the treatment compared to that at the baseline (19.2±3.93 dB, median; 19.34 dB, 20.9±2.92 dB, median; 20.9 dB, respectively). The BCVA was also significantly improved from 0.18±0.19 median; 0.15 logarithm of the minimum angle of resolution (logMAR) units at the baseline to 0.07±0.15 median; 0 logMAR units at 12 months (P<0.001) and to 0.049±0.16 median; -0.039 logMAR units at 24 months (P<0.001). We conclude that half-time PDT results in a significant improvement of the mean central retinal sensitivity for at least 24 months in eyes with chronic CSC. Thus, half-time PDT is beneficial in resolving chronic CSC for a relatively long period.

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“…A 4-2-staircase strategy with Goldmann III-sized stimuli was used with 25 stimulus locations within 12°, as previously described (Fig. 4 A) 31 . To investigate the correlation between visual function and OCT parameters, retinal sensitivity was superimposed on OCT images for all subjects (Fig.…”

Section: Methodsmentioning

confidence: 99%

Assessment of macular function in patients with non-vascularized pigment epithelial detachment

Kitano

¹

,

Fujita

²

,

Asaoka

³

et al. 2021

Sci Rep

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Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.

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“…A 4-2-staircase strategy with Goldmann III-sized stimuli was used with 25 stimulus locations within 12 degrees, as previously described ( Figure 3A). 29 To investigate the correlation between visual function and OCT parameters, retinal sensitivity was superimposed on OCT images for all subjects ( Figure 3B). Retinal sensitivities inside (RSin) and outside (RSout) the PED area were calculated.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Macular Function in Patients With Non-Vascularized Pigment Epithelial Detachment

Asaoka

¹

,

Inoue

²

,

Amari

³

et al. 2020

Preprint

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0

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Non-vascularized pigment epithelial detachments (PED) are usually associated with dry age-related macular degeneration (AMD). In this study, we aimed to investigate the correlation between visual function and morphologic parameters. Seventeen eyes of eleven patients with non-vascularized AMD were enrolled. In addition to conventional optical coherence tomography (OCT), polarization-sensitive optical coherence tomography (PS-OCT) measurements were performed by evaluating the regularity of retinal pigment epithelium (RPE) entropy within the PED area. Retinal sensitivity was measured with MP-3 microperimetry, and retinal sensitivities within (RSin) and outside (RSout) the PED area were calculated. The relationship between OCT parameters and visual function was analyzed. As a result, there was a significant difference between the RSin and RSout (p < 0.001, Wilcoxon signed rank test). Moreover, RSin was significantly related to logMAR VA (p = 0.033, linear mixed model). The regularity of RPE entropy was significantly related to visual acuity and RSin (p = 0.00038, p = 0.031, linear mixed model), although neither the height nor area of PED correlated with visual function. Our results suggest that retinal sensitivity is significantly deteriorated within the PED area and RPE entropy measured with PS-OCT was closely related to visual function in eyes with non-vascularized PED.

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Association between visual function and the integrity of residual ellipsoid zone in resolved central serous chorioretinopathy

Cited by 29 publications

References 41 publications

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Assessment of macular function in patients with non-vascularized pigment epithelial detachment

Assessment of Macular Function in Patients With Non-Vascularized Pigment Epithelial Detachment

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