Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas

Shahar, Suzana; Lee, Lai Kuan; Rajab, Nor Fadilah; Lim, Cheng Leong; Harun, Nur Amira; Noh, Mohd Fairul Nizal Md; Then, Sue Mian; Jamal, A. Rahman A.

doi:10.1179/1476830512y.0000000013

Cited by 28 publications

(17 citation statements)

References 35 publications

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“…We did not observe the effect of APOE rs429358 or rs7412 polymorphism on cognition (MoCA score) in the old Chinese subjects. This result was in line with Shahar and coworker’s study [ 35 ]. In their study, the authors found that APOE genotype was not associated with mild cognitive impairment (MCI).…”

Section: Discussionsupporting

confidence: 93%

Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

et al. 2015

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Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer’s disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in old Chinese adults, a community-based cross-sectional study was carried out in 477 Chinese adults aged from 55 to 75. Information on demography and lifestyle of the participants was collected with a questionnaire. Cognitive function was measured by using a Montreal Cognitive Assessment (MoCA) test. Fasting venous blood samples were collected for APOE rs429358, rs7412 and GSTM1/T1 genotyping, and parameter measurement. No association of APOE rs7412, rs429358 and GSTM1/T1 polymorphisms with cognition was detected in the old Chinese adults. APOE rs429358, rs7412 polymorphism was mainly associated with plasma α-tocopherol, low density lipoprotein cholesterol (LDL-C) and plasma total antioxidant capacity (T-AOC) levels (p < 0.05). Interaction of APOE rs429358 and GSTT1 genotype on the plasma triglyceride (TG) level and erythrocyte catalase (CAT) and GST enzyme activities were detected (p < 0.05). The subjects with APOE rs429358 T/C + C/C and GSTT1− genotype were found to have the highest plasma TG level, erythrocyte CAT enzyme activity, and the lowest GST enzyme activity compared to subjects with other genotypes (p < 0.05). Lowest erythrocyte CAT enzyme activity and highest glutathione peroxidase (GSH-Px) enzyme activity were detected in the subjects with APOE rs7412 T/C + T/T and GSTM1+ genotype as compared with subjects with other genotypes. The levels of plasma and erythrocyte antioxidant parameters were APOE genotype associated. GSTM1 or GSTT1 genotype modified the influence of APOE rs7412, rs429358 polymorphism on antioxidant parameters.

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Section: Discussionsupporting

confidence: 93%

Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

et al. 2015

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“…Alzheimer’s disease (AD) is the commonest type of dementia and it is postulated to cause 60– 80% of cases worldwide (WHO, 2020; Alzheimer’s Association [AA], 2020). While older age group is recognized as the greatest risk factor for AD (AA, 2020; Rivan et al, 2020; Ibrahim et al, 2019), there are multiple other factors that are responsible for cognitive decline (Hussin et al, 2019; Lee et al, 2012; Shahar et al, 2013; Meramat et al, 2015). One of the most important non-modifiable risk factors is the apolipoprotein E (APOE) genotype which has been implicated in late-onset Alzheimer’s disease (LOAD).…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E genotype and MRI-detected brain alterations pertaining to neurodegeneration: A systematic review

Mohamad²,

Suppiah

et al. 2021

Preprint

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IntroductionThe effect of apolipoprotein E (APOE) genotype, particularly APOE ε4, the main genetic risk factor for late-onset Alzheimer’s disease (LOAD), has been widely explored in neuroimaging studies pertaining to older adults. The goal of this systematic review was to review the literature on the relationship between carriage of the APOE ε4 allele and grey matter (GM) changes across various age groups and its influence on neurodegeneration as evidenced by structural magnetic resonance imaging (MRI).MethodsA search of the electronic databases Pubmed, Scopus, Ovid and Cochrane was carried out till March 2020. Only studies published in English were included. Risk of bias of each study was assessed using the modified Newcastle-Ottawa Scale.ResultsA total of 115 articles met the inclusion criteria. Methodological quality varied from poor to good. There is moderate evidence of reduced GM volume in the middle frontal gyrus, precuneus, hippocampus, hippocampal subfields, amygdala, parahippocampal gyrus, middle temporal lobe, whole temporal lobe, temporal pole, and posterior cingulate cortex in APOE ε4 carriers.ConclusionThe present data supports the utility of the hippocampal GM volume to evaluate early structural neurodegenerative changes that occurs in APOE ε4 positive elderly individuals who are at increased risk of developing LOAD. Furthermore, the evidence supports serial measurements and comparison of hippocampal volume based on age group, to track the progression of neurodegeneration in APOE ε4 carriers. Additional longitudinal studies are necessary to confirm whether the combination of MRI-detected hippocampal atrophy with APOE ε4 carrier status, can better predict the development of LOAD in cognitively normal individuals.

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“…Similarly, vitamins implicated in the one-carbon metabolism pathway (e.g., folate, cobalamin, and pyridoxal phosphate) are of particular interest in the elderly, because age-dependent conditions, including cardiovascular diseases and different kinds of cancer, may be partly explained by inadequate status of these vitamins [12]. Previous studies on tocopherol isoforms in elderly populations have mainly focused on potential associations with and effects on the immune system, infectious diseases, oxidative stress, and osteoporosis [13][14][15][16][17][18][19][20]. A study that investigated potential associations of circulating concentrations of both αand γ-tocopherol in elderly subjects in the general population of Germany was more focused on diet and lipids and did not include components related to one-carbon metabolism [21].…”

Section: Introductionmentioning

confidence: 99%

Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

et al. 2020

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Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

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Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas

Abstract: The study highlighted the importance of maintaining good nutritional status and vitamin A status for optimal cognitive function. The presence of APOEε4 allele has a prominent role in affecting vitamin E levels, particularly among cognitively healthy elderly in our unique population.

Cited by 28 publications

References 35 publications

Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults

Apolipoprotein E genotype and MRI-detected brain alterations pertaining to neurodegeneration: A systematic review

Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

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