Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Maidana, Patricia; Fritzler, Analy; Mocarbel, Yamile; Lana, Maria Belén Perez; González, Diego; Rosales, Mónica; Chazal, F. González de; Sternberg, Kevan; Majek, E. Lamas; Mallea-Gil, Susana; Genovesi, E.; Pelayo, Míriam Pérez; Fabre, Bibiana; Mesch, Viviana

doi:10.1038/s41598-019-40653-z

Cited by 14 publications

(16 citation statements)

References 44 publications

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“…Previous studies have shown inconsistent results in terms of vitamin D levels in PCOS women, which have mainly been in opposition with the present results [16,44,46], although this has not been the case in all studies [9,45]. Studies reporting lower vitamin D levels in women with PCOS have been conducted with fairly small sample sizes, recruiting cases from infertility clinics without considering substantive confounding factors [9,16,46]. Recent studies suggest that lower 25(OH)D levels are associated with prolonged menstrual cycles in healthy women [47] and that vitamin D supplementation promotes follicle development and restores menstrual cycles in women with PCOS [6,48].…”

Section: Discussioncontrasting

confidence: 99%

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Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

et al. 2019

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Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels. Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.

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Section: Discussioncontrasting

confidence: 99%

“…Elevated androgen levels in PCOS cause unfavorable derangements in adipose tissue and in glucose metabolism [16]. It has been proposed that the connection between vitamin D and PCOS arises from the endocrine pathways affected in PCOS, such as sex hormone synthesis and insulin secretion [17,18].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

et al. 2019

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“…In this study we used waist circumference as an indicator of visceral adiposity, which was positively associated with hsCRP, HOMA and HbA1C in women with PCOS. This is in keeping with another study which found a positive association between hsCRP and waist circumference in women with PCOS [31]. We also found a negative correlation between hsCRP and %ASM in women with PCOS which is consistent with studies in older adults [27] and obese individuals [32].…”

Section: Discussionsupporting

confidence: 93%

“…In this study, plasma 25-hydroxyvitamin D correlated positively with %ASM and negatively with waist circumference in women with PCOS. These results are consistent with others who have demonstrated a positive association between vitamin D and percent lean mass in obese individuals [32] and a negative association between vitamin D and waist circumference in women with PCOS [31]. Furthermore, vitamin D remains positively associated with skeletal muscle mass after adjusting for body fat mass in obese individuals [39].…”

Section: Discussionsupporting

confidence: 92%

Polycystic ovary syndrome is a risk factor for sarcopenic obesity: a case control study

et al. 2019

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Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young women and increases risk of cardiovascular and metabolic disease, and infertility. Women with PCOS share many characteristics commonly associated with aging including chronic inflammation and insulin resistance, which may be associated with “sarcopenic obesity”, a term used to describe low appendicular skeletal muscle mass relative to total body mass. The purpose of this work was to determine the prevalence of sarcopenic obesity in women with PCOS. We hypothesized there would be a high prevalence of sarcopenic obesity, and that % appendicular skeletal muscle mass and markers of inflammation and insulin resistance would be inversely correlated in this population. Methods Dual energy X-ray absorptiometry was used to assess body composition in 68 women with PCOS aged 18-35y and 60 healthy age-matched women from the same geographic area. Sarcopenic obesity was defined as having % appendicular skeletal muscle mass 2 standard deviations below the mean for the healthy age-matched controls and a % body fat above 35%. Data were analyzed with Mann-Whitney U-tests and Spearman correlations. Results 53% of women with PCOS were classified as sarcopenic obese. Women with PCOS had a median (interquartile range) appendicular skeletal muscle mass of 23.8 (22.3–25.8)% which was lower than the control median of 30.4 (28.6–32.4)% ( p < 0.0001). Among women with PCOS, there were negative correlations between % appendicular skeletal muscle mass and the homeostasis model assessment insulin resistance index ( r = − 0.409; p < 0.01), high sensitivity C-reactive protein ( r = − 0.608; p < 0.0001) and glycosylated hemoglobin ( r = − 0.430; p < 0.0001). Furthermore, % appendicular skeletal muscle mass correlated positively with vitamin D ( r = 0.398; p < 0.0001) in women with PCOS, which is thought to positively affect skeletal muscle mass. Conclusions Women with PCOS have a high prevalence of sarcopenic obesity, which is correlated to insulin resistance and inflammation.

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“…Mean ± SD CRP values were not provided in 22 studies [ 42 , 46 , 60 , 62 , 63 , 65 , 66 , 68 , 72 , 73 , 78 , 82 , 83 , 92 , 93 , 99 , 108 , 110 , 112 , 118 , 119 , 121 ]. Authors of these articles were contacted to provide the missing data, but no response was received despite several reminders.…”

Section: Resultsmentioning

confidence: 99%

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

101

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Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

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Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Cited by 14 publications

References 44 publications

Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

Polycystic ovary syndrome is a risk factor for sarcopenic obesity: a case control study

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

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