2022
DOI: 10.3399/bjgp.2021.0623
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Association between vitamin D and incident herpes zoster: a UK Biobank study

Abstract: Background: Although vitamin D has immunomodulatory effects, any association with herpes zoster (HZ) is unclear. Aim: To explore the association between vitamin D status and the risk of incident HZ in adults in the UK. Design and setting: We conducted a cohort study including participants from UK Biobank, who had at least one vitamin D testing result with linked primary care electronic health records. Methods: The primary exposure was vitamin D status, categorised as deficient (< 25 nmol/L), insufficient (2… Show more

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Cited by 3 publications
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“…We lacked information on other causes of immunosuppression, which might impact serological responses to HHV infections. However, the estimated prevalence of severe immunosuppression (defined as the presence of organ transplantation, chemoradiotherapy, cell-mediated immunosuppressive conditions, bone marrow transplantation, and long-term oral steroid use by codes in linked EHRs and self-report in the 5 years before baseline) in UK Biobank participants was only 3.2% [ 34 ], so this is unlikely to be a major source of bias.…”
Section: Discussionmentioning
confidence: 99%
“…We lacked information on other causes of immunosuppression, which might impact serological responses to HHV infections. However, the estimated prevalence of severe immunosuppression (defined as the presence of organ transplantation, chemoradiotherapy, cell-mediated immunosuppressive conditions, bone marrow transplantation, and long-term oral steroid use by codes in linked EHRs and self-report in the 5 years before baseline) in UK Biobank participants was only 3.2% [ 34 ], so this is unlikely to be a major source of bias.…”
Section: Discussionmentioning
confidence: 99%