Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials

Zhu, Zhixin; Zhu, Xiaoxia; Gu, Lanfang; Zhan, Yancen; Chen, Liang; Li, Xiuyang

doi:10.3389/fnut.2021.799709

Cited by 16 publications

(14 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides TB, the relationship between vitamin D and acute respiratory infections (ARIs) has also been extensively discussed ( Figures 4 , 5 ). Several studies of RCTs reveal that vitamin D supplementation has a protective effect against influenza ( 46 , 47 ). The sixth-ranked highly cited article (presented in Table 2 ) showed that serum 25(OH)D levels were inversely associated with acute upper respiratory tract infection ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of the global research status and trends of the association between Vitamin D and infections from 2001 to 2021

Deng

Luo

2022

Front. Public Health

View full text Add to dashboard Cite

ObjectiveThe objective of this study was the visualization of hot spots and evolving trends in research on the association between vitamin D and infections through the use of bibliometric analysis.MethodsBased on 3046 relevant articles collected in the Web of Science Core Collection for the period of 2001–2021, the data were processed using CiteSpace software. GraphPad software was used for some of the graphics.ResultsA total of 3,046 literature were retrieved, with an average citation frequency of 27.89 times. The number of published papers in the direction of “Immunology” (453 articles, 14.9%) and “Infectious diseases” (312 articles, 10.2%) is much higher. The United States presents the highest publication count (890, 29.2%) and shows a strong leadership in this field. Country burst shows that since 2015, many developing countries and low-income countries have carried out enthusiastic research in this regard, including China, Pakistan, and Iran. As for institutions, the League of European Research Universities produces a larger proportion of articles (220, 7.2%). In terms of authors, Martineau AR and Camargo CA have the highest number of published articles, contributing 30 (0.99%) and 28 articles (0.92%), respectively. Major studies are supported by the United States Department of Health Human Services funding (394, 12.9%). According to the keyword co-occurrence diagram, the 10 most frequent keywords from 2001 to 2021 are “vitamin D”, “infection”, “d deficiency”, “risk”, “association”, “expression”, “disease”, “d supplementation”, “vitamin d deficiency”, and “children”. The top 10 cited articles in 2021 are all related to COVID-19, suggesting it is a hotspot in recent times.ConclusionResearch on the association between vitamin D and infection has grown rapidly since 2012 and is generally developing well. While developed Western countries continue to be leading roles in this field, research trends in developing countries are also very promising. It is demonstrated that the relationship between vitamin D and respiratory infections, especially respiratory viruses and the more recently COVID-19, has received a lot of attention in the last two decades, suggesting that this is the hotspot and frontier of research issue.

show abstract

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of the global research status and trends of the association between Vitamin D and infections from 2001 to 2021

Deng

Luo

2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Reviews on vitamin C suggest that preventative benefits may be dependent on gender (males), environmental conditions and certain stressors an individual may be exposed to; this will require future attention [ 66 , 67 , 68 ]. A number of systematic reviews have looked at vitamin D, especially since the COVID-19 pandemic [ 67 , 78 , 80 , 81 , 82 , 83 ]. Sub-group analyses have shown that vitamin D may be beneficial as a daily dose over a short-term, but for which individuals with which baseline levels or involving what stressors is not yet fully understood.…”

Section: Discussionmentioning

confidence: 99%

Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Immune health products represent approximately 10% of all US dietary supplement sales. Claims made on products to support or boost the immune system are attractive to the otherwise healthy consumer who may or may not be experiencing certain life stressors. The purpose of this systematic review is to critically evaluate the purported benefits and/or potential harms of select dietary supplement ingredients frequently listed on the labels of products having immune health or related market claims. With a focus on resilience, research questions were related to whether dietary supplement ingredients are efficacious in preserving and protecting immune health in healthy individuals; and when faced with a stressor, whether taking a supplement prophylactically can assist in maintaining health and resisting or bouncing back more quickly. Thirty-nine randomized controlled studies involving populations including children, adults and seniors exposed to stressors, such as air travel, intense exercise, academic stress, and/or exposure to winter weather, met eligibility criteria. The studies included eight of the 27 supplement ingredients identified through a market-driven scoping review. Those ingredients used in single ingredient products were echinacea, elderberry, garlic, vitamin A, vitamin C, vitamin D, vitamin E, and zinc. Whereas some studies may point to evidence for benefit, specific gaps preclude the authors from making firm statements with regard to the overall evidence-base for these products and ingredients and in answering the research questions. As we move toward a vision of health promotion and resilience rather than a sole focus on disease prevention and treatment, further work in this area of dietary supplements is of utmost importance.

show abstract

“…Low vitamin D status is associated with poorer outcomes following acute respiratory diseases including influenza [ 1 ]. Vitamin D supplements are touted as being useful in high doses for reducing the severity of seasonal influenza [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs

et al. 2022

View full text Add to dashboard Cite

Vitamin D supplementation is linked to improved outcomes from respiratory virus infection, and the COVID-19 pandemic renewed interest in understanding the potential role of vitamin D in protecting the lung from viral infections. Therefore, we evaluated the role of vitamin D using animal models of pandemic H1N1 influenza and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. In mice, dietary-induced vitamin D deficiency resulted in lung inflammation that was present prior to infection. Vitamin D sufficient (D+) and deficient (D−) wildtype (WT) and D+ and D− Cyp27B1 (Cyp) knockout (KO, cannot produce 1,25(OH)2D) mice were infected with pandemic H1N1. D− WT, D+ Cyp KO, and D− Cyp KO mice all exhibited significantly reduced survival compared to D+ WT mice. Importantly, survival was not the result of reduced viral replication, as influenza M gene expression in the lungs was similar for all animals. Based on these findings, additional experiments were performed using the mouse and hamster models of SARS-CoV-2 infection. In these studies, high dose vitamin D supplementation reduced lung inflammation in mice but not hamsters. A trend to faster weight recovery was observed in 1,25(OH)2D treated mice that survived SARS-CoV-2 infection. There was no effect of vitamin D on SARS-CoV-2 N gene expression in the lung of either mice or hamsters. Therefore, vitamin D deficiency enhanced disease severity, while vitamin D sufficiency/supplementation reduced inflammation following infections with H1N1 influenza and SARS-CoV-2.

show abstract

Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials

Cited by 16 publications

References 42 publications

Bibliometric analysis of the global research status and trends of the association between Vitamin D and infections from 2001 to 2021

Bibliometric analysis of the global research status and trends of the association between Vitamin D and infections from 2001 to 2021

Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review

Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs

Contact Info

Product

Resources

About