Association between vitamin D concentrations and knee pain in patients with osteoarthritis

Abstract

ObjectivesOsteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain.Subjects and MethodsVitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50 ng/mL).ResultsOf 149 patients (133 women), the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients, grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status.ConclusionSerum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

The effectiveness of vitamin D supplementation in functional outcome and quality of life (QoL) of lumbar spinal stenosis (LSS) requiring surgery

“…The effect of vitamin D on the functional outcome and QoL of patients with LSS has not been elucidated but may be deduced from several studies. There is much debate about the pain relief effect of Vitamin D. Although it is a study of idiopathic chronic LBP, Cannell et al [17] have reported on the pain relief effect of vitamin D. Helde-Frankling et al [18] have commented on the pain reducing effect of Vitamin D, Cakar et al [19] said that in a cohort of 149 patients, the authors found that serum vitamin D concentration was not associated with knee pain in patients with osteoarthritis, and Heuch et al [20] said that after analyzing a data set including 1685 individuals with LBP and 3137 controls without LBP, the authors found no association between vitamin D status and risk of LBP. In addition, it appears that vitamin D may have an effect to enhance mood, but there are not sufficient studies regarding accurate mechanism [21].…”

Implementation of a community-based, physiotherapy-led, multidisciplinary model of care for the management of knee osteoarthritis: protocol for a feasibility study

“…In the postintervention phase, a further 26 patients will be recruited, and the assessment process repeated to determine whether there is a change in practice. The feasibility outcome measures are: (1) number of patients who are recorded as receiving care according to current evidence-based guidelines; (2) number of patients who have patient-reported outcomes incorporated into their assessment and management plan; and (3) acceptability of the developed model to patients and physiotherapists. The clinical outcomes will include assessment of patient-reported outcome measures (pain, function, etc) in the preintervention and postintervention phases (baseline and 12 weeks) to assess trends towards change in participant symptoms.…”

“…Knee osteoarthritis (OA) is a degenerative joint disease affecting the cartilage and surrounding structures of the synovial joint. 1 Strengths and limitations of this study ► The study will rely on the highest level of evidence to benchmark current practice and inform the intervention. ► Physiotherapy practices that cover a diverse range of geographic regions, socioeconomic groups and physiotherapist experience levels will be included.…”

“…Knee osteoarthritis (OA) is a degenerative joint disease affecting the cartilage and surrounding structures of the synovial joint. 1 The condition results in pain, loss of muscle strength and disability, with detrimental effects on mental health and quality of life (QoL). 1–3 OA is the most common form of arthritis, 4 with more than 15% of Australians affected.…”

“… 1 The condition results in pain, loss of muscle strength and disability, with detrimental effects on mental health and quality of life (QoL). 1–3 OA is the most common form of arthritis, 4 with more than 15% of Australians affected. 5 This figure is projected to rise to almost 25% by 2050.…”