Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders

Yoo, Taeyoung; Choi, Wonsuk; Hong, JinHee; Lee, Ju‐Yeon; Kim, Jae-Min; Shin, Il‐Seon; Yang, Soo Jin; Amminger, G. Paul; Berk, Michael; Yoon, Jin Sang; Kim, Sung‐Wan

doi:10.30773/pi.2017.08.30

Cited by 8 publications

(5 citation statements)

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“…The association with metabolic syndrome was near significance (p=0.06). This association has been extensively validated in non-SZ populations (Archontogeorgis et al, 2018;Barbalho et al, 2018;Zhu and Heil, 2018), which may suggest a power lack in the present study that would be consistent with the results of Yoo et al (Yoo et al, 2018). No association between vitamin D blood level and hs-CRP blood level has been found, while extensive works have shown the impact of vitamin D on peripheral inflammation (Garbossa and Folli, 2017).…”

Section: No Association Between Positive and Negative Symptoms And Hysupporting

confidence: 86%

“…Preliminary findings have suggested that vitamin D supplementation may improve cognition in schizophrenia , however the association of hypovitaminosis D with cognitive impairment has not been explored to date. Vitamin D insufficiency has been associated with metabolic syndrome in psychotic disorders (Yoo et al, 2018), with insulin resistance (Garbossa and Folli, 2017), with thyroid dysfunction (Kim, 2017;Wang et al, 2018) and high vitamin D blood levels have been suggested to reduce peripheral low-grade inflammation (Zhu et al, 2015). There is a current debate on the association between alcohol use disorder and vitamin D deficiency (Tardelli et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Fond

Godin

Schürhoff

et al. 2018

Psychiatry Research

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Section: No Association Between Positive and Negative Symptoms And Hysupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Fond

Godin

Schürhoff

et al. 2018

Psychiatry Research

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“…In the previous studies, vitamin D deficiency was observed in 60% of postmenopausal women with metabolic syndrome from Lithuania [ 31 ]. In a Korean study, vitamin D insufficiency was also found to be significantly associated with the presence of metabolic syndrome and hypertension in patients with psychotic disorders [ 32 ]. The previous data showed a link between MetS and major depressive disorder [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations in Rural and Urban Postmenopausal Women

2020

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Background and objectives: Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones, as well as factors related to heart disease. The aim of the study was to assess the impact of serum thyroid stimulating hormone (TSH) and vitamin D concentrations as well as metabolic syndrome on the severity of depression in Polish postmenopausal women from urban and rural areas. Materials and Methods: The study was conducted in 2018–2019 in the Lublin region, Poland, and comprised 396 postmenopausal women (239 living in rural areas and 157 living in urban areas). Metabolic syndrome criteria according to the International Diabetes Federation and Beck Depression Inventory were used, and laboratory blood tests were performed. Results: A significantly higher percentage of the examined rural residents had moderate or severe depression in comparison to the urban ones (p = 0.049). The examined women from rural areas had a significantly higher serum vitamin D concentration in comparison to the urban ones (p < 0.001). The rural residents more commonly had below-normal levels of serum TSH and less commonly had normal levels in comparison to the urban residents. Metabolic syndrome was found in 70% of the rural residents, and that number was significantly lower in the urban ones (22%, p < 0.001). Conclusions: The severity of depression in postmenopausal Polish women was correlated negatively with the serum TSH concentration in women from rural areas. The severity of depression was increased in urban postmenopausal women with hypertension. No correlation of the depression severity with the serum vitamin D concentration or other criteria of metabolic syndrome was found.

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“…Large RCTs with sufficient follow-up are required to examine the treatment potential of vitamin D supplementation in schizophrenia and other psychotic disorders. Besides amelioration of symptoms, vitamin D supplementation may also be beneficial in reducing physical comorbidity in psychotic disorder, such as decreased bone mineral density (Gomez et al ., 2016), inflammation (Zhu et al ., 2015), metabolic syndrome (Bruins et al ., 2017; Yoo et al ., 2018) and cardiovascular risk (Lally et al ., 2016). These are important issues as the degree of excess natural-cause mortality in psychotic disorder is striking (Reininghaus et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D concentration and psychotic disorder: associations with disease status, clinical variables and urbanicity

et al. 2019

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BackgroundThe association between schizophrenia and decreased vitamin D levels is well documented. Low maternal and postnatal vitamin D levels suggest a possible etiological mechanism. Alternatively, vitamin D deficiency in patients with schizophrenia is presumably (also) the result of disease-related factors or demographic risk factors such as urbanicity.MethodsIn a study population of 347 patients with psychotic disorder and 282 controls, group differences in vitamin D concentration were examined. Within the patient group, associations between vitamin D, symptom levels and clinical variables were analyzed. Group × urbanicity interactions in the model of vitamin D concentration were examined. Both current urbanicity and urbanicity at birth were assessed.ResultsVitamin D concentrations were significantly lower in patients (B = −8.05; 95% confidence interval (CI) −13.68 to −2.42; p = 0.005). In patients, higher vitamin D concentration was associated with lower positive (B = −0.02; 95% CI −0.04 to 0.00; p = 0.049) and negative symptom levels (B = −0.03; 95% CI −0.05 to −0.01; p = 0.008). Group differences were moderated by urbanicity at birth (χ2 = 6.76 and p = 0.001), but not by current urbanicity (χ2 = 1.50 and p = 0.224). Urbanicity at birth was negatively associated with vitamin D concentration in patients (B = −5.11; 95% CI −9.41 to −0.81; p = 0.020), but not in controls (B = 0.72; 95% CI −4.02 to 5.46; p = 0.765).ConclusionsLower vitamin D levels in patients with psychotic disorder may in part reflect the effect of psychosis risk mediated by early environmental adversity. The data also suggest that lower vitamin D and psychopathology may be related through direct or indirect mechanisms.

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Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders

Cited by 8 publications

References 53 publications

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations in Rural and Urban Postmenopausal Women

Vitamin D concentration and psychotic disorder: associations with disease status, clinical variables and urbanicity

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