Association between vitamin D receptor gene variants and neonatal sepsis: A systematic review and meta‐analysis

Darnifayanti, Darnifayanti; Rizki, Diva Rayyan; Amirah, Shakira; Abdurrahman, Muhammad Fahd; Akmal, Muslim; Abdulmadjid, S.N.; Yusuf, Sulaiman; Iqhrammullah, Muhammad

doi:10.1016/j.jiph.2024.01.011

Journal of Infection and Public Health

2024

DOI: 10.1016/j.jiph.2024.01.011

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Association between vitamin D receptor gene variants and neonatal sepsis: A systematic review and meta‐analysis

Darnifayanti Darnifayanti,

Diva Rayyan Rizki,

Shakira Amirah

et al.

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2024

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QSTR Models in Dioxins and Dioxin-like Compounds Provide Insights into Gene Expression Dysregulation

Eleazar,

Carrera,

Quiambao

et al. 2024

Toxics

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Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are a group of organic chemicals containing three-ring structures that can be substituted with one to eight chlorine atoms, leading to 75 dioxin and 135 furan congeners. As endocrine-disrupting chemicals (EDCs), they can alter physiological processes causing a number of disorders. In this study, quantitative structure–toxicity relationship (QSTR) studies were used to determine the correlations between the PCDD/Fs’ molecular structures and various toxicity endpoints. Strong QSTR models, with the coefficients of determination (r2) values greater than 0.95 and ANOVA p-values less than 0.0001 were established between molecular descriptors and the endpoints of bioconcentration, fathead minnow LC50, and Daphnia magna LC50. The ability of PCDD/Fs to bind to several nuclear receptors was investigated via molecular docking studies. The results show comparable, and in some instances better, binding affinities of PCDD/Fs toward the receptors relative to their natural agonistic and antagonistic ligands, signifying possible interference with the receptors’ natural biological activities. These studies were accompanied by the molecular dynamics simulations of the top-binding PCDD/Fs to show changes in the receptor–ligand complexes during binding and provide insights into these compounds’ ability to interfere with transcription and thereby modify gene expression. This introspection of PCDD/Fs at the molecular level provides a deeper understanding of these compounds’ toxicity and opens avenues for future studies.

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QSTR Models in Dioxins and Dioxin-like Compounds Provide Insights into Gene Expression Dysregulation

Eleazar,

Carrera,

Quiambao

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

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Association between vitamin D receptor gene variants and neonatal sepsis: A systematic review and meta‐analysis

Cited by 1 publication

References 45 publications

QSTR Models in Dioxins and Dioxin-like Compounds Provide Insights into Gene Expression Dysregulation

QSTR Models in Dioxins and Dioxin-like Compounds Provide Insights into Gene Expression Dysregulation

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