Association between vitamin D receptor polymorphisms and susceptibility to Parkinson's disease: An updated meta-analysis

Gao, Jinzhao; Teng, Jijun; Liu, Zongchao; Cai, Min; Xie, Anmu

doi:10.1016/j.neulet.2020.134778

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…A recent meta-analysis has analyzed the associations between all reported VDR polymorphisms and PD risk, showing a clear association between the FokI and susceptibility to PD in overall populations, particularly in Asian subgroups, whereas no relationship between TaqI, ApaI or BsmI, and PD was found [ 74 ].…”

Section: Role Of Vitamin D In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

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Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.

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Section: Role Of Vitamin D In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

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“…Vitamin D deficiency is commonly found in both PD and melanoma and is associated with a more aggressive disease course [9]. Cutaneous pigmentation is regulated by vitamin D through enhancement of melanogenesis [53], and Vitamin D receptor subtypes may modulate the risk of both PD and melanoma [54,55]. Transcranial sonography of the midbrain reveals an extended hyperechogenic area in the SN in more than 90% of PD patients [56].…”

Section: Neuropathymentioning

confidence: 99%

Parkinson's disease and skin

Niemann

Billnitzer

Jankovic

2021

Parkinsonism & Related Disorders

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Parkinson's disease is associated with a variety of dermatologic disorders and the study of skin may provide insights into pathophysiological mechanisms underlying this common neurodegenerative disorder. Skin disorders in patients with Parkinson's disease can be divided into two major groups: 1) non-iatrogenic disorders, including melanoma, seborrheic dermatitis, sweating disorders, bullous pemphigoid, and rosacea, and 2) iatrogenic disorders related either to systemic side effects of antiparkinsonian medications or to the delivery system of antiparkinsonian therapy, including primarily carbidopa/levodopa, rotigotine and other dopamine agonists, amantadine, catechol-O-methyl transferase inhibitors, subcutaneous apomorphine, levodopa/carbidopa intestinal gel, and deep brain stimulation. Recent advances in our understanding of the role of α-synuclein in peripheral tissues, including the skin, and research based on induced pluripotent stem cells derived from skin fibroblasts have made skin an important target for the study of Parkinson's disease pathogenesis, drug discovery, novel stem cell therapies, and diagnostics.

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“…All of the SNPs had a function already reported in the literature or predicted by the SNP function prediction tool ( Xu and Taylor, 2009 ). We selected SNPs based on their previous association with PD and related phenotypes ( Kim et al, 2005 ; Han et al, 2012 ; Suzuki et al, 2012 ; Török et al, 2013 ; Gatto et al, 2015 ; Li et al, 2015 ; Niu et al, 2015 ; Wang et al, 2019 ; Gao et al, 2020 ; Hu et al, 2020 ; Agliardi et al, 2021 ) and based on their location in the gene and minor allele frequency (MAF). Only very common SNPs with the MAF above 10% were selected.…”

Section: Methodsmentioning

confidence: 99%

“…Genetic variability in VDR has already been investigated in several different settings. More specifically, VDR rs2228570 was associated with the risk of PD development ( Han et al, 2012 ; Török et al, 2013 ; Li et al, 2015 ; Niu et al, 2015 ; Wang et al, 2019 ; Gao et al, 2020 ; Hu et al, 2020 ; Agliardi et al, 2021 ). This single nucleotide polymorphism (SNP) was also associated with the disease progression ( Suzuki et al, 2012 ) and with cognitive decline in PD patients ( Gatto et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson’s Disease and Dopaminergic Treatment Adverse Events

Redenšek

Kristanc

Blagus

et al. 2022

Front. Aging Neurosci.

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Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson’s disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. The aim of this study was to assess the associations of VDR genetic variability with PD risk and different PD-related phenotypes. We genotyped 231 well characterized PD patients and 161 healthy blood donors for six VDR single nucleotide polymorphisms, namely rs739837, rs4516035, rs11568820, rs731236, rs2228570, and rs1544410. We observed that VDR rs2228570 is associated with PD risk (p < 0.001). Additionally, we observed associations of specific VDR genotypes with adverse events of dopaminergic treatment. VDR rs1544410 (GG vs. GA + AA: p = 0.005; GG vs. GA: p = 0.009) was associated with the occurrence of visual hallucinations and VDR rs739837 (TT vs. GG: p = 0.036), rs731236 (TT vs. TC + CC: p = 0.011; TT vs. TC: p = 0.028; TT vs. CC: p = 0.035), and rs1544410 (GG vs. GA: p = 0.014) with the occurrence of orthostatic hypotension. We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes.

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Association between vitamin D receptor polymorphisms and susceptibility to Parkinson's disease: An updated meta-analysis

Cited by 14 publications

References 35 publications

Vitamin D Status and Parkinson’s Disease

Vitamin D Status and Parkinson’s Disease

Parkinson's disease and skin

Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson’s Disease and Dopaminergic Treatment Adverse Events

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