Association between weight-adjusted waist index and non-alcoholic fatty liver disease: a population-based study

Yu, Changhui; He, Shiming; Kuang, Maobin; Wang, Chao; Huang, Xin; Sheng, Guotai; Zou, Yang

doi:10.1186/s12902-024-01554-z

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…However, the validity of these indicators needs to be confirmed by more extensive clinical studies. In recent years, it has been found that WWI is a superior predictor of non-alcoholic fatty liver disease [ 33 ], low cognitive performance [ 27 ], hyperuricemia [ 28 ], diabetic kidney disease [ 42 ], kidney stones [ 30 ], stress urinary incontinence [ 31 ], and depressive symptoms [ 43 ]. WWI has excellent potential as an anthropometric indicator because of its easy computation and strong ability to forecast disease onset [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…The weight-adjusted-waist index (WWI) represents a novel metric for obesity assessment, demonstrating enhanced precision in quantifying lean muscle and adipose tissue mass when juxtaposed with traditional measures such as BMI and waist circumference (WC) [ 26 , 27 ]. The literature suggests that WWI is associated with a variety of conditions, including fatty liver, cognitive function, hyperuricemia, diabetes mellitus, kidney stones, dyslipidemia, and urinary incontinence [ 28 , 27 , 29 – 33 ]. It may serve as a more accurate predictor of risk.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Guo,

Qing,

Chen

et al. 2024

Eat Weight Disord

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Background Amidst growing evidence of the intricate link between physical and mental health, this study aims to dissect the relationship between the waist-to-weight index (WWI) and suicidal ideation within a representative sample of the US population, proposing WWI as a novel metric for suicide risk assessment. Methods The study engaged a sample of 9500 participants in a cross-sectional design. It employed multivariate logistic and linear regression analyses to probe the association between WWI and suicidal ideation. It further examined potential nonlinear dynamics using a weighted generalized additive model alongside stratified analyses to test the relationship's consistency across diverse demographic and health variables. Results Our analysis revealed a significant positive correlation between increased WWI and heightened suicidal ideation, characterized by a nonlinear relationship that persisted in the adjusted model. Subgroup analysis sustained the association's uniformity across varied population segments. Conclusions The study elucidates WWI's effectiveness as a predictive tool for suicidal ideation, underscoring its relevance in mental health evaluations. By highlighting the predictive value of WWI, our findings advocate for the integration of body composition considerations into mental health risk assessments, thereby broadening the scope of suicide prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Guo,

Qing,

Chen

et al. 2024

Eat Weight Disord

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Weight-adjusted-waist index: an innovative indicator of breast cancer hazard

Huang,

Cheng,

Deng

et al. 2024

BMC Women's Health

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Background Central obesity and breast cancer (BC) have been identified as relevant by empirical research. The weight-adjusted-waist index (WWI) is a novel methodology for quantifying central obesity. Inspection of the association between WWI and BC in American adult women was the primary goal of the current investigation. Methods Cross-sectional assessments were conducted on information gathered from 10,193 National Health and Nutrition Examination Survey (NHANES) participants from 2011 to 2018. The waist circumference was divided by the square root of the body’s mass to compute WWI. Data were assessed via descriptive statistics to present data distributions according to BC grouping and WWI grouping, receiver operating characteristic curves (ROCs) to evaluate the obesity indicators’ applied value, logistic regression to reflect associations between WWI and BC prevalence, and restricted cubic splines (RCSs) and subgroup analysis forest plots to visualise and complement the relationships. Results This study enrolled 10,193 participants whose WWI ranged from 8.38 to 14.41, 259 of whom were diagnosed with BC, and the results revealed significant differences in baseline characteristics between the groups. With an area under the curve (AUC) value (95% confidence interval) (CI)of 0.611 (0.577–0.644), WWI was a promising indicator of BC with good application value rather than waist circumference (WC), body mass index (BMI), or waist-height ratio (WHtR). WWI and BC laid out a substantial relationship, yielding an odds ratio (OR) of 1.54 and a 95% CI of (1.34, 1.79), which remained at 1.19 (1.00, 1.42) after considerable adjustments were made, according to the logistic regression analysis. Compared with the lowest quartile of WWI, the highest quartile had a 62% greater in the probability of suffering from BC. With the RCS’s inverted U-shape highlighting the importance of considering the nonlinear nature of the relationship and subgroup analyses reflecting variations among populations, all the results demonstrated that WWI was a well-suggestive indicator of BC hazard. Conclusion The current investigation revealed a meaningful association between the prevalence of BC and WWI, which was superior to other obesity indicators, albeit one that was more complex than the positive relationship initially derived. There existed a turning point for BC prevalence at WWI of approximately 12 cm/√kg. Nevertheless, maintaining WWI in the lower range is critical for preventing and administering BC and minimizing disease risk.

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Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018

Liu,

Yang,

Zhan

et al. 2024

Front. Endocrinol.

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BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease. Body mass index (BMI) is the most used obesity index but has important limitations. The weight-adjusted waist index (WWI) is a novel obesity metric and accurately reflects body composition. We explored the association of WWI with all-cause and cardiovascular disease (CVD) mortality in MASLD.MethodsAdult participants with MASLD were included from NHANES 1999-2018. WWI was calculated by dividing the waist circumference (WC) by the square root of body weight. MASLD was diagnosed by the presence of hepatic steatosis and at least one cardiometabolic risk factor in the absence of other causes of steatosis. A fatty liver index ≥60 suggested the presence of hepatic steatosis. Mortality data was obtained by prospectively linking to the National Death Index. Multivariate Cox proportional hazards regression analyses were used to explore these associations and multiple adjustment models were constructed including crude, partial, and fully adjusted models.ResultsAfter adjusting for all covariates including BMI, WWI remained positively and linearly associated with all-cause and CVD mortality in MASLD (hazard ratios [HR] 1.247 and 1.218, respectively). Higher WWI was associated with a significantly increased risk of mortality (both p for trend <0.05). There was an “obesity paradox” between BMI and all-cause mortality in MASLD, with significantly lower all-cause mortality in those with overweight/obesity compared to normal BMI (HR 0.625 and 0.596, respectively, p for trend = 0.024), and no association between BMI and CVD mortality. Interaction analyses indicated that these associations were influenced by several demographic variables and disease status. Time-dependent receiver operating characteristic curves indicated that the predictive value of WWI for mortality in MASLD was higher than that of BMI, WC, and waist-to-height ratio across all follow-up durations.ConclusionsWWI was positively and linearly associated with all-cause and CVD mortality in MASLD, whereas BMI did not accurately reflect mortality risk. WWI provided the optimal predictive value for mortality compared to traditional obesity indicators. These findings emphasize the potential use of WWI as a novel obesity indicator for mortality risk assessment, stratification, and prevention in MASLD.

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Association between weight-adjusted waist index and non-alcoholic fatty liver disease: a population-based study

Cited by 3 publications

References 46 publications

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES

Weight-adjusted-waist index: an innovative indicator of breast cancer hazard

Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018

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