Association between weight gain and knee osteoarthritis: a systematic review

Solanki, Pravik; Hussain, Sultana Monira; Abidi, J.; Cheng, Jun; Fairley, Jessica; Page, Matthew J.; Cicuttini, Flavia Maria; Wluka, Anita E.

doi:10.1016/j.joca.2022.10.023

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…In pathology, OA was considered a disease of the whole joint, including alterations in the articular cartilage, subchondral bone, ligaments, capsule, and synovial membrane, ultimately leading to joint failure 15 . In the development of primary OA, increasing age 16 , weight 17 , and obesity 18 were independent risk factors. Here, our study suggests that emotion also impacts OA genetically.…”

Section: Discussionmentioning

confidence: 97%

The causal relationship between Emotions and Osteoarthritis: A Bidirectional Mendelian Randomization study

Pan,

Jin,

Zhou

et al. 2023

Preprint

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Background Osteoarthritis is a global joint disease and its prevalence is still rising. At the same time, emotion disorder is also a huge problem in the whole world, previous studies suggested the relationship between emotion disorder and osteoarthritis. However, the causality effect is still unknown. Method A bidirectional Mendelian randomization study was designed to estimate the causality effect of emotion on osteoarthritis. The instrument single nucleotide polymorphisms were screened from open Genome-Wide Association Study summary (GWASs) datasets. The Inverse-Variance Weighted was deemed as the main effect, and the MR_Egger, Weighted Medium, Weighted mode, and Simple Mode were performed to complement the results. Results The emotions of depression, anxiousness, and feeling hurt were genetic effects of the development of osteoarthritis. Among them, the anxiousness was relegated to the risk of osteoarthritis (Odds Ratio [OR] 0.49, 95% Confidence Interval [CI] 0.26–0.91). The emotion of depression (OR 2.16, 95% CI 1.61–2.90) and hurt (OR 1.73, 95% CI 1.09–2.75) promoted the risk of osteoarthritis at the genetic level. Conclusion The emotion was genetic effect the risk of osteoarthritis, especially depression and feeling hurt.

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Section: Discussionmentioning

confidence: 97%

The causal relationship between Emotions and Osteoarthritis: A Bidirectional Mendelian Randomization study

Pan,

Jin,

Zhou

et al. 2023

Preprint

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“…Furthermore, weight gain in adults has been linked with an increased incidence of clinical and structural KOA and Total Knee Replacement (TKR). Therefore, preventing weight gain should be considered a practical approach to improve outcomes for individuals with KOA [21].…”

Section: Weight Managementmentioning

confidence: 99%

Analysis of the current situation of quality of life in young-old patients with knee osteoarthritis and its prevention and treatment strategies

Gao,

Leng,

Liu

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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Osteoarthritis of the knee (KOA) is a condition with an increased prevalence of morbidity. The proportion of senior citizens has increased, and this population will continue to grow. Several studies investigated the impact of KOA patient prevention and treatment on their health-related quality of life (HRQOL). Young-old patients with KOA may have a lower quality of life (QOL). In recent decades, the clinical treatment of KOA has diversified, and Western medicine has achieved rapid results, especially in surgical treatment. However, there is still controversy over the long-term efficacy after surgery, with some surgeries being complex. Traditional Chinese medicine appears to have a unique and beneficial effect on the HRQOL improvement of elderly patients with knee osteoarthritis. However, the majority of prior studies did not compare the effects of Western therapy and traditional Chinese medicine on the HRQOL of KOA patients. Interventions to improve the HRQOL of young-old patients with KOA are currently unknown. This study evaluated HRQOL of young-old (60-74 years) patients with KOA. While there are some effective KOA prevention and treatment options. The research was hampered by an absence of solid evidence from randomised controlled trials and a paucity of studies examining the influence of KOA on the QOL of the young-old. Despite these limitations, it is anticipated that this study will provide a theoretical reference for enhancing the QOL and friendliness of elderly patients with KOA.

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“…It significantly affects daily activities such as climbing stairs and squatting. Severe cases may experience intense pain even during walking, further impacting the physical and mental health as well as the quality of life (QOL) of patients [ 6 , 7 ].Currently, there are three main categories of standardized treatment methods for KOA: pharmacological treatment, nonpharmacological treatment, and surgical treatment [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of Yoga on patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

Lu,

Kang,

Huang

et al. 2024

PLoS ONE

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Objective The objective of this review is to conduct a comprehensive and systematic assessment of the efficacy of Yoga as an intervention for knee osteoarthritis (KOA). Methods We searched PubMed, Cochrane Library, Embase, Web of Science, and PEDro as of January 3, 2024. Retrieved a total of 200 articles. Standardised mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Results The study included a total of 8 trials and involved 756 KOA patients. The results indicated that compared to the control group, Yoga exercise showed significant improvements in alleviating pain (SMD = -0.92; 95% CI = -1.64 ~ - 0.20; P = 0.01, I2 = 94%), stiffness (SMD = -0.51; 95% CI = -0.91 ~ -0.12; P = 0.01; I2 = 66%) and physical function (SMD = -0.53; 95% CI = -0.89 ~ -0.17; P = 0.004; I2 = 59%) among KOA patients. However, there was no significant improvement observed in terms of activities of activity of daily living (ADL) (SMD = 1.03; 95% CI = -0.01 ~ 2.07; P = 0.05; I2 = 84%), and quality of life (QOL) (SMD = 0.21; 95% CI = -0.33 ~ 0.74; P = 0.44; I2 = 83%) with the practice of Yoga. Conclusions In general, Yoga has been found to be effective in reducing pain and stiffness in KOA patients, it can also improve the physical function of patients. However, there is limited evidence to suggest significant improvements in terms of ADL and QOL.

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Association between weight gain and knee osteoarthritis: a systematic review

Cited by 11 publications

References 46 publications

The causal relationship between Emotions and Osteoarthritis: A Bidirectional Mendelian Randomization study

The causal relationship between Emotions and Osteoarthritis: A Bidirectional Mendelian Randomization study

Analysis of the current situation of quality of life in young-old patients with knee osteoarthritis and its prevention and treatment strategies

The impact of Yoga on patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

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