Association between weight or body mass index and hand osteoarthritis: a systematic review

Yusuf, Erlangga; Nelissen, Rob G H H; Ioan‐Facsinay, Andreea; Stojanovic-Susulic, V.; DeGroot, Jeroen; Osch, Gerjo van; Middeldorp, Saskia; Huizinga, Tom W J; Kloppenburg, Margreet

doi:10.1136/ard.2008.106930

Cited by 385 publications

(286 citation statements)

References 47 publications

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“…Gender and age are established strong determinants of hand OA (31,32). A study was considered subject to potential confounding if gender and age were not taken into account in the study design (balanced distribution across exposure groups) or by statistical analysis.…”

Section: Confoundingmentioning

confidence: 99%

Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis

Hammer¹,

Shiri²,

Kryger³

et al. 2013

Scand J Work Environ Health

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Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis by Hammer PEC, Shiri R, Kryger AI, Kirkeskov L, Bonde JPThe current meta-analysis provides limited support for the hypothesis that occupational activities involving pinch motion are causally linked to development of hand osteoarthritis. For exposure to hand grip or hand-arm vibration the evidence is insufficient due to inconsistent results Affiliation 133Review Scand J Work Environ Health. 2014;40(2):133-145. doi:10.5271/sjweh.3409 Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis Objective We systematically reviewed the epidemiologic evidence linking finger and wrist osteoarthritis (OA) with work activities requiring pinch or hand grip or exposure to hand-arm vibration (HAV).Methods PubMed and Embase databases were searched up to June 2013. We selected studies assessing the associations of radiographic diagnosed finger and/or wrist joint OA with work activities involving pinch or hand grip or exposure to HAV. We used specific criteria to evaluate completeness of reporting, potential confounding, and bias. Pooled odds ratios (OR) were computed using random-effects meta-analyses. ResultsOf the 19 studies included, 17 were cross-sectional, 1 was a prospective cohort, and 1 a case-control study. The meta-analyses of studies that controlled their estimates for at least age and gender showed the associations of pinch grip work with proximal interphalangeal joint [OR 1.56, 95% confidence interval (95% CI) 1.09-2.23] and the first carpometacarpal joint OA (OR 2.10, 95% CI 1.06-4.17), but not with distal interphalangeal, metacarpalphalangeal, or wrist joints OA. Hand grip work and exposure to HAV were not associated with any finger or wrist OA. ConclusionEpidemiological studies provide limited evidence that pinch grip may increase the risk of wrist or finger OA, but causal relation cannot be resolved because of cross-sectional designs and inadequate characterization of biomechanical strain to the hand and wrist.

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Section: Confoundingmentioning

confidence: 99%

Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis

Hammer¹,

Shiri²,

Kryger³

et al. 2013

Scand J Work Environ Health

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“…Evidence suggests that there is a metabolic link between obesity and OA [13][14][15][16][17]32]. The knee joint is the only joint in which there is localized adipose tissue, recognized also as being metabolically active [20][21][22][23]25], and the joint most often affected by OA.…”

Section: Discussionmentioning

confidence: 99%

“…This link is in part believed to be a metabolic one [13], in addition to the recognized impact of increasing mechanical forces on weight-bearing joints [12]. Many individuals experience OA symptoms in non-weight bearing joints as well [14][15][16]. Indeed, studies are revealing associations between levels of adipose-derived factors in blood and/or synovial fluid and the presence or severity of osteoarthritis, particularly the knee [17,18].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

Weston¹

2015

J Arthritis

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IntroductionThere is now compelling evidence that adipose tissue is metabolically active and that adipose derived metabolic factors can have physiological effects [1,2]. In adults, fat exists primarily as white adipose tissue. This tissue is widely distributed throughout the body with the two most prevalent forms being subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).SAT accounts for the vast majority of all the fat in the body [3,4] and potentially is a major source of adipose derived factors in the systemic circulation [5]. Each type of adipose tissue displays unique phenotypic and genotypic characteristics [6]. Some have suggested that each fat type may have differing developmental lineages that play a role in body fat distribution, obesity and the variety of functional properties of various adipose tissue sites in the body [7]. Previous work has shown that inflammatory hormones secreted by adipocytes and macrophages can significantly affect expression levels of leptin, adiponectin, tumour necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in SAT [1,[8][9][10]. The systemic release of these adipose-derived hormones is thought to be responsible for the low-grade inflammatory state commonly observed in obese individuals [6,11,12].The link between obesity and osteoarthritis (OA) has long been established [13]. This link is in part believed to be a metabolic one [13], in addition to the recognized impact of increasing mechanical forces on weight-bearing joints [12]. Many individuals experience OA symptoms in non-weight bearing joints as well [14][15][16]. Indeed, studies are revealing associations between levels of adipose-derived factors in blood and/or synovial fluid and the presence or severity of osteoarthritis, particularly the knee [17,18].Osteoarthritis is most prevalent in the knee [15], and association between OA and obesity has been particularly marked for this joint [16]. Thus, the knee likely provides an ideal setting in which to examine any potential role(s) of fat on OA development/progression, particularly as it is the only joint to contain a large intra-articular deposit of adipose tissue. The infrapatellar fat pad (IFP) is an intracapsular and extrasynovial structure, distinguishable from SAT and VAT by its unique location and relative size [19][20][21][22][23][24]. AbstractObjective: Previous research has examined gene expression of the IFP from individuals with early and endstage knee OA. However, there is little understanding of whether the differential expression that was found is a local effect associated with OA disease severity. The objective of this study was to compare gene expression of the SAT and IFP both within individuals with early and late stage knee OA.Methods: Knee SAT and corresponding IFP samples were harvested from twenty-nine patients with endstage and five patients with early stage OA at the time of knee surgery. Total RNA was then extracted, labelled and hybridized to Illumina whole genome expression arrays. Arrays were scanned and intensity of hybridi...

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“…Получены новые данные о патогенезе ОА, которые сви-детельствуют, что энзимы, участвующие в деградации хряща, относятся к семейству металлопротеиназ (ММР) и регулируются провоспалительными цитокинами; синовит различной интенсивности практически облигатно присут-ствует при ОА, и его интенсивность коррелирует с прогно-зом [29,30]; ожирение при ОА не только оказывает меха-ническое воздействие на опорные суставы, но и играет роль в развитии ОА кистей [31]; наличие метаболического синдрома (абдоминальное ожирение, сахарный диабет или инсулинорезистентность, повышение уровня холестерина и артериальная гипертензия) также является независимым фактором риска развития ОА [32], его прогрессирования и увеличения боли [33]. Многочисленные исследования под-тверждают, что метаболические нарушения участвуют в регуляции воспаления при ОА [34], поскольку и лептины, и адипокины участвуют в патогенезе ОА, а инфрапателляр-ный жир является локальным паракринным медиатором суставного воспаления -источником растворимых медиа-торов (цитокинов IL-1, IL-4, IL-5, IL-6, IL-8, IL-13, интерферона-γ и фактора некроза опухоли; хемокинов, адипо-кинов, факторов роста, дериватов липидов, таких как арахидоновая кис-лота и простагландин Е 2 ) (рис.…”

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Modern Osteoarthritis Therapy: Alflutop in Clinical Practice, Experimental and Clinical Data

Чичасова¹

2017

Med. sov.

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Association between weight or body mass index and hand osteoarthritis: a systematic review

Abstract: Weight or BMI is associated with the development of hand osteoarthritis. The level of evidence of published studies is moderate according to best-evidence synthesis. Further high-quality cohort or case-control studies are needed to elucidate the role of weight in hand osteoarthritis.

Cited by 385 publications

References 47 publications

Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis

Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis: a meta-analysis

Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

Modern Osteoarthritis Therapy: Alflutop in Clinical Practice, Experimental and Clinical Data

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