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Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte volume fraction (EVF)), leukocyte count (total count, lymphocytes, neutrophils) and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). The associations between increasing copeptin tertile and the hematopoietic markers were analyzed in multivariate linear regression analyses. We found that increasing copeptin tertile was significantly (p < 0.001) associated with increasing erythrocytes, RDW, EVF, Hb, leukocytes and neutrophils after adjustment for age, sex, current smoking, prevalent diabetes, hypertension, creatinine, body mass index and physical activity. Increasing copeptin tertile was, however, not associated with change in MCV, lymphocyte or thrombocyte count. In conclusion, we found that increasing copeptin levels are positively associated with markers of erythropoiesis and leukocyte count in the general population. These results warrant further research on possible mechanistic effects of vasopressin on hematopoiesis.
Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte volume fraction (EVF)), leukocyte count (total count, lymphocytes, neutrophils) and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). The associations between increasing copeptin tertile and the hematopoietic markers were analyzed in multivariate linear regression analyses. We found that increasing copeptin tertile was significantly (p < 0.001) associated with increasing erythrocytes, RDW, EVF, Hb, leukocytes and neutrophils after adjustment for age, sex, current smoking, prevalent diabetes, hypertension, creatinine, body mass index and physical activity. Increasing copeptin tertile was, however, not associated with change in MCV, lymphocyte or thrombocyte count. In conclusion, we found that increasing copeptin levels are positively associated with markers of erythropoiesis and leukocyte count in the general population. These results warrant further research on possible mechanistic effects of vasopressin on hematopoiesis.
Objectives One of the major risk factors for cardiovascular disease is obesity, particularly abdominal and visceral obesity. Another concern for it is inflammation. Both risk factors are interrelated as obesity is a state of subacute low-grade systemic inflammation. As neck circumference and waist-hip ratio are potential indicators of obesity, we wanted to compare the level of total leukocyte count in subjects with normal and high neck circumference and waist-hip ratio. We also wanted to observe whether there is any correlation between neck circumference and waist-hip ratio with total leukocyte count. Methods We selected 62 subjects (30 males, and 32 females) for the study. Both males and females were categorized into groups of normal and high neck circumference and waist-hip ratios. The total leukocyte count was compared among the groups and we correlated neck circumference and waist-hip ratios with total leukocyte count. Statistical analysis was done with SPSS version 23.0. Results We observed a statistically significant higher value of total leukocyte count in males with a high waist-hip ratio. But there was not a significant increase in TLC in males with high neck circumference. In females, the values were insignificant. On Pearson correlation, there was a negative correlation between neck circumference, waist-hip ratio, and total leukocyte count in both genders which is not significant. Conclusions These findings suggest that waist-hip ratio rather than neck circumference might be a proxy measure of a marker of inflammation in males.
Background Observational studies have identified associations between haematological traits and type-2 diabetes mellitus (T2D). However, it is difficult to infer causal effects due to the potential of confounding. Our study utilizes the Mendelian randomization (MR) approach to address the above limitation and investigate the causal effect of haematological traits (HT) such as white blood cell (WBC) count, platelet count, haemoglobin (Hb) levels, and red blood cell (RBC) count, on T2D in individuals of African ancestry. Methods The participating cohorts included participants of African ancestry in the Blood Cell consortium (n = 15,171) and the Million Veteran Program dataset (N=53,445: Ncases =23,305; Ncontrol = 30,140). We applied a univariable, bidirectional, and multivariable Two-sample MR to estimate the causal relationship between haematological traits and T2D using GWAS summary statistics. Genetic instruments for haematological traits and T2D included only the variants that attained a genome-wide significant level (P ≤ 5 × 10−8) of association with the respective exposure. The inverse-variance weighted MR approach was used in the main analysis, complemented by sensitivity analyses that are more robust to the inclusion of pleiotropic variants, including MR-Egger and MR-PRESSO. We further evaluated the genetic correlation between the hematological traits and T2D using linkage disequilibrium score regression (LDSC). Results In the main inverse-variance weighted (IVW) MR estimates, genetically predicted mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) levels were associated with decreased risk of T2D. Genetically predicted higher RBC was significantly associated with an increased risk of T2D. For WBC traits, there was evidence of protective effects of total WBC count and neutrophil count (NEU) on T2D. In the reverse analysis, genetically predicted T2D liability was associated with lower levels of RBC distribution width (RDW) and elevated levels of lymphocyte count (LYM). The multivariable analysis supported direct effects of genetically predicted MCH, MCHC, RDW, MCV, and lower levels of WBC with decreased risk of T2D. Additionally, LDSC showed negative genetic correlation of T2D with haematocrit (HCT) and haemoglobin concentration (HGB), and positive with eosinophil (EOS) and platelet count (PLT), suggesting that there is a genetic basis for the association between T2D and these blood traits. Conclusion These findings indicate that haematological traits may differentially play a role in the development of T2D and be affected by T2D. However, further research is needed to validate and explore the biological pathways and mechanisms involved in these associations.
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