Association between winter season and desmopressin treatment efficiency in children with monosymptomatic nocturnal enuresis: a pilot study

Sun, Mengkui; Li, Shoulin; Sun, Xuerui; Deng, Zhimei; Xu, Yanan

doi:10.1590/s1677-5538.ibju.2021.0236

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Besides that, recently Sun et al (18) proposed that the winter season and high severity of initial symptoms are two high risk factors for desmopressin treatment failure; this is corroborated by Bastos Netto and Bessa Junior (19) in their editorial comment paper; they also describe some differences in sleeping architecture which could cause influence in this multifactorial and very complex mechanism of nocturnal urinary production. Just another piece of this complex puzzle.…”

Section: Discussionmentioning

confidence: 80%

Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery

et al. 2022

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Introduction: Upper airway obstruction (UAO) is a common condition in all pediatric population, with a 27% prevalence. Primary monosymptomatic nocturnal enuresis (PMNE) is a condition related to UAO in 8% to 47% of these children. The specific pathophysiological mechanism of this bond is not well understood. Some authors suggest a connection between brain natrituretic peptide (BNP) and anti-diuretic hormone (ADH) during sleep. The aim of this study was to evaluate hormone profile (ADH and BNP) and improvement in dry nights in a sample of children before and after surgical treatment of the UAO. Methods: This is a longitudinal prospective interventionist study in children, 5 to 14 years of age, with UAO and PMNE recruited in a specialty outpatient clinic. Children presenting UAO and PMNE were evaluated with a 30-day dry night diary and blood samples were collected to evaluate ADH and BNP before and after upper airway surgery. Data were analyzed prior to surgery and 90-120 days after surgery. Results: Twenty-one children with a mean age of 9.7 years were included. Mean BNP before surgery was 116.5 ± 126.5 pg/mL and 156.2 ± 112.3 pg/mL after surgery (p<0.01). Mean ADH was 5.8 ± 3.2 pg/mL and 14.6 ± 35.4 before and after surgery, respectively (p=0.26). The percentage of dry nights went from 32.3 ± 24.7 before surgery to 75.4 ± 33.4 after surgery (p˂0.01). Conclusion: Surgery for airway obstruction contributed to an increase in BNP without increasing ADH. A total of 85.8% of the children presented partial or complete improvement of their enuresis.

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Section: Discussionmentioning

confidence: 80%

Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery

et al. 2022

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“…A retrospective study in 393 children with primary enuresis monosymptomatic describe that winter season was associated with desmopressin treatment failure. We did not observe possible interference from colder weather due to the Covid-19 pandemic emergence and its protective measures during much time of the study ( 30 ).…”

Section: Discussionmentioning

confidence: 86%

Treating asthma in patients with enuresis: repercussions on urinary symptoms

Dahan,

Oliveira,

Brum

et al. 2023

Int. braz j urol.

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Background: Children presenting enuresis are more likely to be asthmatics. The association between enuresis and sleep-disordered breathing has already been demonstrated and several studies have shown at least partial improvement of two thirds or more of the cases of enuresis adenoidectomy. Studies have already described associations between enuresis and allergies but do not assess the repercussions of allergy treatment in enuretics. Objective: This study aims to evaluated whether asthma treatment alters the course of enuresis and whether there is any predictive factor associated with this improvement. Materials and Methods: Twenty patients (5 - 12 years old) with uncontrolled enuresis and asthma, received treatment for asthma. Children were also assessed for the presence of rhinitis and other allergies. The control of asthma was confirmed by a validated questionnaire and primary enuresis by clinical history and wet night diaries. Patients received only asthma treatment. Results: At least partial improvement of enuresis was observed in 55% of the patients with an increase in 64.4% in the number of dry nights at the end of the study (p=0.01). The “presence of other allergies” and “obstruction seen in nasal endoscopy” positively influenced the improvement of urinary symptoms (OR = 3.350; CI 0.844–13.306) and (OR=1.272; CI 0.480-3.370), respectively. Discussion: Until now, only patients presenting upper airway obstruction were known to benefit from the improvement of urinary symptoms when undergoing treatment for their respiratory problems. In our study, we found at least partial improvement in enuresis in 55% of our patients, with only clinical asthma treatment. Conclusion: Controlling asthma in children with primary enuresis resulted in a significant increase in dry nights.

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“…The exact etiology of enuresis is not yet fully understood. It is considered multifactorial (1,2,(6)(7)(8)(9)(10)(11). One of the main factors involved in the pathophysiology of enuresis are hereditary factors (1,2,(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of parasacral transcutaneous electrical nerve stimulation in the treatment of monosymptomatic enuresis in children and adolescents: a systematic review

Dutra,

Bessa Junior,

Almeida

et al. 2024

Int. braz j urol.

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Background: Parasacral Transcutaneous Electrical Nerve Stimulation (PTENS) is a treatment used in enuresis refractory to first-line treatment. This review aimed to evaluate the effectiveness of PTENS in treating monosymptomatic enuresis (MNE) in children and adolescents. Methods: The study followed the Preferred Reporting Items for Systematic (PRISMA) guidelines. The search was carried out in the following databases: MEDLINE (via PubMed), Web of Science, SCOPUS, Central Cochrane Library and Physiotherapy Evidence Database (PEDro). The selected studies were randomized clinical trials (RCTs). The "Risk of Bias tool for randomized trials" and the "Risk of Bias VISualization" were used to analyze the risk of bias. Results: Of the 624 studies selected, four RCTs were eligible. Three included 146 children and adolescents aged between six and 16.3 years and used similar PTENS protocols with a frequency of 10 Hz, pulse duration of 700 µs and 20 minutes three times/week. One study enrolled 52 patients aged seven to 14 years used PTENS at home, with a pulse duration of 200 µs and 20 to 60 minutes twice/day. Risk of bias was observed in three studies due to results’ randomization and measurement. Two studies showed a partial response with a reduction in wet nights, one a complete response in 27% of patients, and one showed no improvement. Conclusion: PTENS reduces wet nights’ frequency but does not cure them, except in 27% of patients in one study. Limited RCTs and data heterogeneity are limitations.

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Association between winter season and desmopressin treatment efficiency in children with monosymptomatic nocturnal enuresis: a pilot study

Cited by 7 publications

References 21 publications

Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery

Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery

Treating asthma in patients with enuresis: repercussions on urinary symptoms

The effectiveness of parasacral transcutaneous electrical nerve stimulation in the treatment of monosymptomatic enuresis in children and adolescents: a systematic review

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