Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: A meta-analysis

Wang, Yadong; Yang, Haiyan; Li, Haishan; Li, Li; Li, Ang; Liu, Cuie; Zheng, Yuxin

doi:10.1016/j.canlet.2009.05.005

Cited by 55 publications

(47 citation statements)

References 40 publications

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“…Several functional genetic variants, particularly nonsynonymous polymorphisms, have been identified in the XPD, XPG, APE1, XRCC1 and ADPRT genes, and have shown a relationship with DRC variation and susceptibility to multiple cancers (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Additionally, several reviews were also published to summarize the associations between functional variants of DNA repair genes and cancer risk, including HNC, and have provided meaningful results (17,20,26 …”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population

Yuan

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Although tobacco and alcohol consumption are the major risk factors of head and neck cancer (HNC), genetic variations of genes involved in several biological pathways, such as DNA repair genes, may affect an individual's susceptibility to HNC. However, few studies have investigated the associations between polymorphisms in DNA repair genes and HNC risk in the Chinese population. Thus, we genotyped five common, non-synonymous single-nucleotide polymorphisms (SNPs) [APEX1 (Asp148Glu), XRCC1 (Arg399Gln), ADPRT (Val762Ala), XPD (Lys751Gln) and XPG (His1104Asp)] in a hospital-based, case-control study of 397 HNC cases and 900 cancer-free controls in China. The results showed that none of the five SNPs in the DNA repair pathway was significantly associated with HNC risk, suggesting that these polymorphisms may not play a major role in HNC susceptibility in this Chinese population. IntroductionThe incidence of head and neck cancer (HNC), especially squamous cell carcinoma of the head and neck (SCCHN), has markedly increased in the past 20 years and is now the fifth most common type of cancer worldwide (1). In the United States, it is estimated that there were 48,010 new cases and 11,260 deaths from SCCHN in 2010 (2). Accumulative evidence indicates that exposure to smoking and alcohol consumption are important risk factors of HNC (3); however, only few smokers and drinkers develop HNC, suggesting an individual susceptibility to this cancer in the general population. Most association studies on cancer susceptibility have focused on identifying effects of single-nucleotide polymorphisms (SNPs) in candidate genes of several pathways. Among these, genes involved in the DNA repair pathway are the most investigated due to their vital role in protecting the genome from insults of environmental carcinogens (4,5). Studies have shown inter-individual variations of DNA repair capacity (DRC) in the general population and the effect of a suboptimal DRC on the risk of smoking-related cancers, such as lung cancer and SCCHN (6-8).Of DNA repair pathways, nucleotide excision repair (NER) is the major repair mechanism for the DNA damage caused by tobacco smoking, which deals with a wide class of DNA damages, including bulky adducts cross-links, oxidative DNA damage, thymidine dimers and alkylating damage (9). NER involves more than 20 proteins whose inactivation may lead to xeroderma pigmentosum (XP) or Cockayne syndrome (CS). For example, rare mutations in xeroderma pigmentosum complementation group D and G (XPD and XPG) give rise to a combined XP/CS phenotype and are associated with severe neurological abnormalities.The base excision repair (BER) pathway is another important mechanism that repairs DNA damage resulting from chemical alterations of a single base; a number of proteins are involved in repair steps, such as apurinic/apyrimidinic endonuclease (APE1, also known as APEX1), X-ray repair crosscomplementing 1 (XRCC1) and ADP-ribosyltransferase (ADPRT, also known as PARP1) (10). APE1 is a key member in short-patch BER, w...

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Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population

Yuan

et al. 2012

Experimental and Therapeutic Medicine

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“…The genetic factors include candidate genes that might play roles functions in the susceptibility to lung cancer. The XRCC1 gene is an important candidate gene for influencing lung cancer susceptibility (Hao et al, 2006;Giachino et al, 2007;López-Cima et al, 2007;Sreeja et al, 2008;Chang et al, 2009;Kalikaki et al, 2009;Wang et al, 2009;Yin et al, 2009a,b;Butkiewicz et al, 2011;Li et al, 2011;Qian et al, 2011;Chen et al, 2012;Cui et al, 2012;Guo et al, 2013). In the present study, the influence of the XRCC1 c.1804C>A genetic variant on the susceptibility to lung cancer in Chinese Han population was evaluated by association analysis in 348 lung cancer patients and 355 cancer-free control patients.…”

Section: Discussionmentioning

confidence: 88%

“…It is generally accepted that genetic factors play key roles in the pathogenesis of lung cancer. Previous studies reported that the human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes for influencing susceptibility to lung cancer (Hao et al, 2006;Giachino et al, 2007;López-Cima et al, 2007;Sreeja et al, 2008;Chang et al, 2009;Kalikaki et al, 2009;Wang et al, 2009;Yin et al, 2009a,b;Butkiewicz et al, 2011;Li et al, 2011;Qian et al, 2011;Chen et al, 2012;Cui et al, 2012;Guo et al, 2013). The potential associations between lung cancer and multiple genetic variants of XRCC1 in different populations have been reported (Hao et al, 2006;Giachino et al, 2007;López-Cima et al, 2007;Improta et al, 2008;Sreeja et al, 2008;Chang et al, 2009;Kalikaki et al, 2009;Yin et al, 2009a,b;Butkiewicz et al, 2011;Qian et al, 2011;Cui et al, 2012;Guo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of 703 subjects were recruited for this study. Genotyping of c.1804C>A genetic variant was performed using the created restriction site-polymerase chain reaction. Statistically significant differences in allele frequencies and genotype were found between lung cancer patients and cancer-free controls. The genotype AA was statistically associated with the increased risk of lung cancer when compared to the wild genotype, CC, and the carrier genotype, CA/CC (AA vs CC: OR = 2.71, 95%CI = 1.57-4.67, P < 0.001; AA vs CA/CC: OR = 2.54, 95%CI = 1.50-4.29, P < 0.001). The allele A likely contributes to the susceptibility to lung cancer (A vs C: OR = 1.47, 95%CI = 1.17-1.84, P = 0.001). Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population.

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“…Such studies may explore empirical associations that indicate that a polymorphism in a gene of interest has an influence on cancer, independent of metabolic regulatory mechanisms and other genetic and environmental variability. 59 Here, we performed a systematic literature review to evaluate the relationships between the survivin À31G4C promoter polymorphism and the risk of cancer. Individuals with variant genotypes of this polymorphism have an associated increased cancer risk, particularly those of Asian origin, which suggests that this increased risk may be ethno-specific.…”

Section: Discussionmentioning

confidence: 99%

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

Wang

Huang

et al. 2012

Eur J Hum Genet

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Survivin is an inhibitor of apoptosis protein and has a crucial role in the development of cancer. The survivin À31G4C (rs9904341) promoter polymorphism influences survivin expression and has been implicated in cancer risk. However, conflicting results have been published from studies on the association between survivin À31G4C polymorphism and the risk of cancer. To clarify the role of this polymorphism in cancer, we performed a meta-analysis of all available and relevant published studies, involving a total of 3485 cancer patients and 3964 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant genotypes were associated with a significantly increased cancer risk (CC vs GG: OR¼1.58, 95% CI¼1.20-2.10; CC/GC vs GG: OR¼1.23, 95% CI¼1.00-1.51; CC vs GG/GC: OR¼1.51, 95% CI¼1.23-1.85). In the stratified analyses, significantly increased risk was associated with the Asian populations (CC vs GG: OR¼1.67, 95% CI¼1.16-2.40; CC vs GG/GC: OR¼1.50, 95% CI¼1.17-1.91). We also performed the analyses by cancer type, and no statistical association was observed. The results suggest that the survivin À31G4C promoter polymorphism might be associated with an increased risk of cancer, especially in the Asian populations.

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Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: A meta-analysis

Cited by 55 publications

References 40 publications

Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population

Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population

Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

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