Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects

Abstract

The present meta-analysis was intended to explore the relationship between the X-ray repair cross complementing 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and cervical cancer risk. Several electronic databases were searched systematically and bibliographies of relevant papers were identified carefully. Then, a meta-analysis was performed based on eligible studies in various genetic models. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were employed to evaluate the strength of associations between the XRCC1 polymorphisms and cervical cancer risk. Additionally, heterogeneity analysis and sensitivity analysis were done if necessary. Totally, 11 articles involving 2092 cases and 2803 controls were included. Taken together, there was no obvious association between the Arg194Trp or Arg280His polymorphism and cervical cancer risk. Considering the great heterogeneity, subgroup analysis was done, but the pooled result remained stable. Nevertheless, the association between the Arg399Gln polymorphism and cervical cancer risk showed distinct statistic significance in the allele model, dominant model, homozygous model and heterozygous model. In view of the exiting heterogeneity, we did subgroup analysis stratified by ethnicity, resulting in the fact that the Arg399Gln polymorphism was related to the decreased risk of cervical cancer. The Begg's test and Egger's test were used to find no publication bias. To conclude, the current meta-analysis indicated that the XRCC1 Arg399Gln polymorphism decreased the risk of cervical cancer, while the Arg194Trp and Arg280His polymorphisms were not associated with cervical caner risk. Certainly, a well-designed large-scale multicenter study is warranted to confirm the finding.

Assessment of role of genetic polymorphisms in XRCC1, XRCC2 and XRCC3 genes in cervical cancer susceptibility from a rural population: a hospital based case-control study from Maharashtra, India

“…29 On the other hand, in a more recent report showed a weak association of XRCC1 gene in development of CC, however two studies by Zeng et al and Cai et al reported no evidence of association of XRCC genes with CC development. 31,32 Thus, there is a debate between association or no association between XRCC1 gene and risk of development of CC. Also, reports on XRCC2 Arg188His polymorphisms stated that XRCC2 variants were found not to be associated with CC risk.…”

Evaluation of the ERCC2 (Lys751Gln), MSH2 (gIVS12-6TC), RAD54 (Ala730Ala), XPC (Lys939Gln), XPG (Asp1104Hist), XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) gene polymorphisms in the Ecuadorian population with retinoblastoma

“…These differences suggest a possible ethnic variability in allele distribution of XRCC1 [44]. Another study analyzed 1,635 patients with cervical cancer and 2,361 controls, showing that the Arg399Gln polymorphism decreases the susceptibility of such cancer (G vs. A: OR = 0.39, CI of 95% = 0.29-0.51; p < 0.05) [45]. In a meta-analysis in the Caucasian populations, it was found that the A/G and G/G genotypes were associated with the risk of developing lung cancer [46].…”

Hubungan Polimorfisme Gen XRCC1 Arg399Gln Terhadap Kejadian Kanker Serviks Pada Wanita Ras Melayu

“…6 XRCC1 memiliki tiga SNPs umum, varian genetik dalam XRCC1 adalah (C/T) dalam ekson 6 menghasilkan substitusi Arg / Trp pada kodon 194, (G/A) dalam ekson 9 mengubah asam amino Arg / His pada kodon 280 dan polimorfisme lain (G/A) dalam ekson 10 mengubah asam amino Arg / Gln pada kodon 399 pada stabilitas genomik. 6,7,8 Penelitian yang dilakukan pada populasi Asia menunjukkan hubungan yang signifikan antara polimorfisme XRCC1 Arg399Gln dan risiko karsinoma serviks. 9 Polimorfisme genetik adalah adanya variasi genetik pada suatu populasi dengan frekuensi lebih dari satu persen.…”

“…XRCC1 telah dikaitkan dengan pengembangan karsinoma sel skuamosa esofagus, kanker serviks, kanker paru-paru, kanker pankreas, kanker payudara, kanker kolorektal, dan kanker lambung. 7 Kajian tentang polimorfisme gen XRCC1 Arg399Gln telah banyak dilakukan oleh berbagai peneliti dan di negara lain dan menghasilkan hasil yang bervariasi. Liu, dkk (2015) Dalam analisis subkelompok oleh etnis menunjukkan hubungan yang signifikan antara polimorfisme XRCC1 Arg399Gln dan kerentanan terhadap karsinoma serviks pada populasi Kaukasia dan Asia.…”