Association between Zenker diverticulum and gastroesophageal reflux disease: development of a working hypothesis

Sasaki, Clarence T.; Ross, Douglas A.; Hundal, Jagdeep S.

doi:10.1016/s0002-9343(03)00218-3

Cited by 56 publications

(22 citation statements)

References 4 publications

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“…Reports on the association of GERD and Zenker diverticula with elevated upper esophageal sphincter pressure have been published. 11,12 In some reports, even the connection between gastroesophageal reflux disease and achalasia was also suspected. [13][14][15] Furthermore, Sullivan 16 reported that after small intravenous doses of pentagastrin increased the LES pressure in all of eight patients with epigastric pain, which was believed to be due to a HLES.…”

Section: Discussionmentioning

confidence: 99%

Effect of Laparoscopic Fundoplication on Hypertensive Lower Esophageal Sphincter Associated with Gastroesophageal Reflux

Varga

Király

Cseke

et al. 2008

Journal of Gastrointestinal Surgery

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For hypertensive lower esophageal sphincter with dysphagia and chest pain, a laparoscopic cardiomyotomy is recommended. Recently, the role of gastroesophageal reflux in this abnormality has been recognized. A prospective study on six patients with manometrically proven hypertensive lower esophageal sphincter was performed. Laparoscopic floppy Nissen fundoplication was performed in all cases. The first follow up was performed 6 weeks after the operation. The mean follow up time was 56 months (range 50-61). Before the operation, all patients had abnormal esophageal acid exposure. Mean DeMeester score was 41.7 (range 16.7-86). Average LES pressure before the operation was 50.5 mmHg (range 35.6-81.3). Six weeks after operation, all patients were symptom free. DeMeester score returned to a normal level of 2.9. Furthermore, a marked decrease in the lower esophageal sphincter pressure (24.7 mmHg) was detected. At late follow up, all patients were symptom-free, and only two patients agreed to undergo functional testing. The mean DeMeester score of this two patients was 1.2. The pressure remained at normal value (15.7 mmHg). In our study, an antireflux operation normalized lower esophageal sphincter pressure suggesting that abnormal esophageal acid exposure may be an etiologic factor in the development of hypertensive lower esophageal sphincter.

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Section: Discussionmentioning

confidence: 99%

Effect of Laparoscopic Fundoplication on Hypertensive Lower Esophageal Sphincter Associated with Gastroesophageal Reflux

Varga

Király

Cseke

et al. 2008

Journal of Gastrointestinal Surgery

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“…Gastroesophageal reflux disease and Zenker's diverticulum may be associated in up to 95% of the cases [12]. This association may be causal and related to esophageal longitudinal muscle reflex contraction and consequent widening of the gap between pharyngeal constrictors and cricopharyngeus muscles [13] or upper esophageal sphincter spasm [14].…”

Section: Physiopathologymentioning

confidence: 99%

Modern pathophysiology and treatment of esophageal diverticula

Herbella

Patti

2011

Langenbecks Arch Surg

106

114

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“…Most LPR patients do not complain of heartburn. LPR has been implicated in the aetiology of a multitude of otolaryngologic disorders, including subglottic stenosis, chronic sinusitis, chronic otitis media, laryngeal granulomas, paroxysmal laryngospasm, Reinke's oedema, Zenker's diverticulum, and laryngeal carcinoma (Cohen, Bach, Postma, & Koufman, 2002;DelGaudio, 2005;Koufman, 1991;Lewin et al, 2003;Maronian, Azadeh, Waugh, & Hillel, 2001;Sasaki, Ross, & Hundal, 2003).…”

Section: Patient Symptomsmentioning

confidence: 99%

Laryngopharyngeal reflux: Current concepts in pathophysiology, diagnosis, and treatment

Rees

Belafsky

2008

International Journal of Speech-Language Pathology

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Laryngopharyngeal reflux (LPR) is the backflow of gastric contents into the pharynx and larynx. The diagnosis of LPR is primarily based on symptoms, including dysphonia, dysphagia, globus, throat-clearing, and post-nasal drip. The gold standard for diagnosis is dual-probe 24-hour pH testing with the upper probe positioned above the upper oesophageal sphincter. Treatment may require 3 months or more of twice-daily proton pump inhibitors along with lifestyle modifications. This review details the pathophysiology, symptoms, findings, treatment, and current controversies in LPR.

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Association between Zenker diverticulum and gastroesophageal reflux disease: development of a working hypothesis

Cited by 56 publications

References 4 publications

Effect of Laparoscopic Fundoplication on Hypertensive Lower Esophageal Sphincter Associated with Gastroesophageal Reflux

Effect of Laparoscopic Fundoplication on Hypertensive Lower Esophageal Sphincter Associated with Gastroesophageal Reflux

Modern pathophysiology and treatment of esophageal diverticula

Laryngopharyngeal reflux: Current concepts in pathophysiology, diagnosis, and treatment

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