Association between zinc and body composition: An integrative review

Cunha, Thais Alves; Vermeulen-Serpa, Karina Marques; Grilo, Evellyn Câmara; Leite-Lais, Lúcia; Brandão-Neto, José; Vale, Sancha Helena de Lima

doi:10.1016/j.jtemb.2022.126940

Cited by 21 publications

(7 citation statements)

References 53 publications

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“…In addition, increased Zn excretion was observed in obesity. 69 On the other hand, the positive associations observed may be because overweight and obese individuals are more likely to consume Zn-rich foods such as meats, seafood, and nuts than people of normal and low weight. 57 …”

Section: Discussionmentioning

confidence: 99%

The role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review

Abeywickrama,

Uchiyama,

Sumiyoshi

et al. 2023

Nutrition Reviews

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Background Zinc (Zn) deficiency, malnutrition, sarcopenia, and frailty are prevalent among older adults and are prominent factors contributing to disability and mortality. Objective This scoping review was conducted to aid understanding of the extent and types of research addressing the role of Zn in nutritional status, sarcopenia, and frailty, among older individuals. Method A systematic search was performed in August 2022 of 3 electronic databases (PubMed, Web of Science, and ProQuest) using predefined search terms. The review was conducted referring to the Arksey and O’Malley framework and PRISMA-ScR. Results The search retrieved 16 018 records, and a total of 49 studies were included in this review after the screening. Of those, 30 were based on dietary Zn intake, 18 on tissue Zn levels, and 1 on both. Most studies were based on cross-sectional data from community-dwelling older adults. Studies addressing the associations between Zn status and individual anthropometric and sarcopenia-related variables reported inconsistent results. However, most studies reported inverse associations between malnutrition, frailty, and Zn status. Conclusion There was more consistent evidence of the relationship of Zn status with malnutrition, sarcopenia, and frailty rather than with individual nutritional parameters. Validated screening and assessment tools and criteria and prospective studies are required to elucidate the relationship of Zn with sarcopenia and frailty in the older population.

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Section: Discussionmentioning

confidence: 99%

The role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review

Abeywickrama,

Uchiyama,

Sumiyoshi

et al. 2023

Nutrition Reviews

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“…The Ca, Mg, and Zn minerals showed a positive correlation here and were associated with human muscle mass [ 41 ]. Zinc is an essential mineral for lean body mass synthesis, but relatively large amounts of Zn are needed for new tissue synthesis [ 42 ]. Moreover, we found positive correlations between unsaturated fatty acids and Cu and Cr.…”

Section: Discussionmentioning

confidence: 99%

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Bruscadin

Cardoso

Diniz

et al. 2022

Genes

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Traditional transcriptomics approaches have been used to identify candidate genes affecting economically important livestock traits. Regulatory variants affecting these traits, however, remain under covered. Genomic regions showing allele-specific expression (ASE) are under the effect of cis-regulatory variants, being useful for improving the accuracy of genomic selection models. Taking advantage of the better of these two methods, we investigated single nucleotide polymorphisms (SNPs) in regions showing differential ASE (DASE SNPs) between contrasting groups for beef quality traits. For these analyses, we used RNA sequencing data, imputed genotypes and genomic estimated breeding values of muscle-related traits from 190 Nelore (Bos indicus) steers. We selected 40 contrasting unrelated samples for the analysis (N = 20 animals per contrasting group) and used a beta-binomial model to identify ASE SNPs in only one group (i.e., DASE SNPs). We found 1479 DASE SNPs (FDR ≤ 0.05) associated with 55 beef-quality traits. Most DASE genes were involved with tenderness and muscle homeostasis, presenting a co-expression module enriched for the protein ubiquitination process. The results overlapped with epigenetics and phenotype-associated data, suggesting that DASE SNPs are potentially linked to cis-regulatory variants affecting simultaneously the transcription and phenotype through chromatin state modulation.

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“…The relationship between the decrease in SZn with OW/OB has been evaluated through oxidative stress at the level of adipose tissue [ 97 , 101 , 102 ]. To date, the molecular mechanisms are not clear, but it has been shown that under these conditions of OW/OB, the increase in visceral fat due to OW and OB contributes to the secretion of cytokines such as IL-6, IL-8, and TNF-α, as well as an increase in the cortisol synthesis.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City

Martínez-Navarro

Vilchis-Gil

Cossío-Torres

et al. 2022

Biol Trace Elem Res

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Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate the association between serum Zn levels (SZn) with overweight/obesity status (OW/OB), as well as its cardiometabolic traits in a population of children in Mexico City. Anthropometrical data (body mass index z score (BMIz)), demographic variables (age and sex), and cardiometabolic traits (total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), fasting plasma glucose (FPG), and insulin) were analyzed in this cross-sectional study. SZn were measured by inductively coupled plasma mass spectrometry (ICP–MS). The population included 210 children from Mexico City (girls ( n = 105) and boys ( n = 105)) between ages 6 and 10 years. Normal-weight (NW) schoolchildren had higher SZn concentrations (66 µg/dL; IQR: 48 to 91) compared to OW or OB schoolchildren (61 µg/dL; IQR: 45 to 76). The data showed a significant negative association between SZn and BMIz without sex exclusion ( r = − 0.181 and p = 0.009). The boy’s population did not show an association between the SZn and BMIz compared to the girl’s population which showed a significant negative association ( r = − 0.277 and p = 0.004). In addition, other associations were found between SZn and TC (boys ( r = 0.214 and p = 0.025), LDLc (boys ( r = 0.213 and p = 0.029), and TG (girls ( r = − 0.260 and p = 0.007)). Moreover, 38.6% of the total children in our population study had Zn deficiency (ZnD). NW schoolchildren had higher SZn concentrations compared to OW or OB schoolchildren. A diet low in Zn can be a factor to evaluate in the development of childhood OB in Mexico. However, further studies need to be performed on the children Mexican population to replicate and confirm our findings.

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Association between zinc and body composition: An integrative review

Cited by 21 publications

References 53 publications

The role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review

The role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City

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