Association of 15q14 and 15q25 with High Myopia in Japanese

Abstract

These findings suggest that a region in 15q14 is susceptibility loci for high myopia. This locus harbor susceptibility genes for not only common myopia but also for high myopia. The 15q25 locus might also have association to myopia.

Association study of 15q14 and 15q25 with high myopia in the Han Chinese population

“…In a population of Japanese students 3 to 17 years old, the prevalence of myopia increased from 49.3 to 65.6% [3,4]. In other countries, the prevalence of myopia shows variable ratio (36.7–87.2% in a Chinese, 19.8–62.1% in a general Asian group, 5.2–40.5% in a Caucasian group aged 5–17 years, and 2.3–14.7% in Australian children aged from 4 to 12 years [5,6].…”

“…In 2011, Hayasbi et al [3] performed a study to validate whether variations in chromosome 15q14 and 15q25 are associated to refractive error and myopia in the Japanese population, and their results illustrated that rs524952 in 15q14 was associated with high myopia but SNPs in 15q25 were not. Another study of the Han Chinese population conducted by Shi et al [1] found the most significant loci in 15q14 and 15q25 were not associated with high myopia.…”

Evaluation of Pigment Epithelium–Derived Factor and Complement Factor I Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes

“…21 We also found no association from the evaluation of VEGFA, 15q14, and 15q25. 22,23 Recently, Leveziel et al 24 evaluated 15 genes that were reported to be related to AMD, and showed that only one SNP within the CFI gene was associated with the occurrence of CNV secondary to high myopia. However, PEDF, which was also reported to be related to AMD, 29 was not included in their study.…”

“…Thereafter, we conducted three studies to investigate the genetic background of myopic CNV by evaluating likely candidate genes (or loci) such as ARMS2, CFH, HrtA serine peptidase 1 (HTRA1), 15q14, 15q25, and vascular endothelial growth factor A (VEGFA), but we did not find any susceptible genes. [21][22][23] However, VEGFA showed a significant association with the size of myopic CNV, although it did not show an association with the occurrence of myopic CNV. 23 In addition, a recent study reported a positive association between the complement factor I (CFI) gene polymorphism, rs10033900, and the occurrence of CNV by using 71 cases and 196 controls in Caucasians.…”

Vascular Endothelial Growth Factor Gene Polymorphisms and Choroidal Neovascularization in Highly Myopic Eyes

“…7 Furthermore, recent GWASs reveal that myopia susceptibility loci exist in chromosome 15. [8][9][10] The occurrence of CNV in highly myopic eyes might also depend on genetic variations. Thus far, however, few studies have investigated the genetic background of patients with CNV in highly myopic eyes.…”