2021
DOI: 10.18585/inabj.v13i4.1684
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Association of 25-hydroxyvitamin D, Cyclooxygenase-2 and Prostaglandin E2 Serum Levels in Breast Cancer Patients

Abstract: BACKGROUND: Serum levels of 25-hydroxyvitamin D (25(OH)D), prostaglandin E2 (PGE2), and cyclooxygenase 2 (COX2) expression differ between breast cancer stages. Since, previous studies showed mixed results, in this study, we aimed to analyze vitamin D levels related to breast cancer stages and serum levels of COX2 and PGE2 in Indonesia.METHODS: This was a cross sectional study involving 75 breast cancer patients. Subjects were divided into 3 groups, namely operable early stage (K1), locally advanced stage (K2),… Show more

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“…Furthermore, tumor-free condition is mostly experienced by the majority of breast carcinoma survivors for the rest of their lives. (7) Interaction between estrogen and estrogen receptor (ER) results in cell growth stimulation in several different tissues, including in breast epithelial tissue. (8,9) ER takes a part in the regulation and differentiation of normal breast epithelial cells as well as in breast tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, tumor-free condition is mostly experienced by the majority of breast carcinoma survivors for the rest of their lives. (7) Interaction between estrogen and estrogen receptor (ER) results in cell growth stimulation in several different tissues, including in breast epithelial tissue. (8,9) ER takes a part in the regulation and differentiation of normal breast epithelial cells as well as in breast tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%