Association of –607 C/A Polymorphism of IL-18 Gene (rs1946518) with Breast Cancer Risk in Zahedan, Southeast Iran

Taheri, Mohsen; Hashemi, Mohammad; Eskandari-Nasab, Ebrahim; Fazaeli, Aliakbar; Arababi, F; Bahrani-Zeidabadi, M; Bahari, Gholamreza

doi:10.14712/23362936.2015.19

Cited by 16 publications

(23 citation statements)

References 14 publications

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“…We found no correlation between IL-18 −607 C/A polymorphism and predisposition to breast cancer. This result similar to a previous study [17].…”

Section: Discussionsupporting

confidence: 93%

“…Because of the double roles of IL-18 expression and serum level in both tumor metastasis and drug resistance, IL-18 may denote a helpful drug target for therapy of breast cancer [22]. It was clear that two SNPs in the promoter area of the IL-18 gene organized the gene expression levels at the transcriptional stage and changed the IL-18 production level [17]. The alteration from the "C allele to the "A" allele at site −607C/A and at site −137 G/C alternation from the G allele to the C allele in the (promoter area) were prophesied to be the molecular factor linking sites for the cyclic adenosine monophosphate responsive element between protein and H4TF-1 factor, respectively in addition, polymorphisms of the two positions have been correlated with the activity of IL-18 gene promoter transcription, which can impact the IL-18 expression and, may be, of IFN-γ; these changes in alleles, potentially be the essential mechanism of IL-18 involvement in different diseases [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…IL-18 (rs1946518) polymorphisms were detected using (T-ARMS PCR), as mentioned by Taheri et al [17]. Polymerase chain reaction (PCR) was performed using commercially available PCR premix (AccuPower PCR PreMix, BIONEER, South Korea) as described by manufacturer; 1 µl template DNA (50 ng/µl), 1 µl of each primer (10 µM), and 15 µl PCRwater were added to each reaction.…”

Section: Methodsmentioning

confidence: 99%

“…and nasopharyngeal carcinoma [15]. On the other hand, other studies found there were no correlations between −607 C/A polymorphism of IL-18 gene and head and neck squamous cell carcinoma [16] or breast cancer risk [17]. Therefore, our study aims to determine whether there is a link between −607 C/A polymorphism of IL-18 gene with the risk of breast cancer or in our Iraqi sample of the study.…”

Section: Introductionmentioning

confidence: 91%

“…The study was performed using tetra-amplification refractory mutation system-PCR (T-ARMS-PCR) [17]. Fig.…”

Section: Association Between Polymorphisms and Risk Of Breast Cancermentioning

confidence: 99%

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Interleukin-18 Gene Polymorphism and Some Risk Factors in Iraqi Patients With Breast Cancer

Al-Askeri

Jabir²,

Jaber³

2016

Asian J Pharm Clin Res

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Objective: Breast cancer is the most diagnosed cancer in women, which leads to death in a lot of women with breast cancer. The major risk factors associated with breast cancer risk related to family history, age, clinical history, lifestyle factors, long-period hormonal exposure, and single nucleotide polymorphisms in many genes showed possible links with breast cancer incidence risk in different people populations. Our study aimed to figure out the correlation between smoking, lodging and family history, and other factors with the risk of breast cancer.Methods: Blood sample from female patients with breast cancer and healthy individuals were collected and subjected to tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) technique for −607 C/A mutation of an interleukin (IL-18) gene and SPSS 18 software analyzed the results statically. Results:Results showed no association between lodging and smoking with risk of breast cancer, (p>0.05), while the association between the risk and family history were obvious (p<0.05). Conclusion:The results obtained by T-ARMS-PCR technique did not show the association between −607 C/An alternation of IL-18 gene and breast cancer (p>0.05) in the individuals examined in our study.

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“…We found no correlation between IL-18 −607 C/A polymorphism and predisposition to breast cancer. This result similar to a previous study [17].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

“…The study was performed using tetra-amplification refractory mutation system-PCR (T-ARMS-PCR) [17]. Fig.…”

Section: Association Between Polymorphisms and Risk Of Breast Cancermentioning

confidence: 99%

See 3 more Smart Citations

Interleukin-18 Gene Polymorphism and Some Risk Factors in Iraqi Patients With Breast Cancer

Al-Askeri

Jabir²,

Jaber³

2016

Asian J Pharm Clin Res

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Association of genetic variants in the interleukin‐18 gene promoter with risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus infection

2018

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Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, characterized by high vascularization and rapid tumor progression. The current case-control study aimed to analyze the influence of -607C/A and -137G/C polymorphisms in the interleukin-18 (IL-18) promoter on the risk of HCC occurrence and metastasis in Egyptian patients infected with hepatitis C virus (HCV). Both genetic variations were genotyped in 279 subjects including HCV patients with and without HCC and unrelated healthy subjects, using the allele-specific polymerase chain reaction (AS-PCR) method. The relationship between clinico-laboratory parameters including serum level of alpha-fetoprotein (AFP) and these polymorphisms was evaluated in HCC patients. The IL-18-607A allele and AA genotype were significantly related to a higher risk of developing HCC when comparing patients with HCC and controls, and were significantly related to a higher risk of metastasis when comparing metastatic and nonmetastatic groups in the Egyptian patients. In contrast, the IL18-137C allele and GC genotype were significantly related to a lower risk of developing HCC when comparing patients with HCC and controls, and HCV patients with and without HCC. A significant association was found between multinodular HCC and IL-18-607AA genotype, while, uninodular HCC was significantly associated with IL-18-137GG genotype. In addition, IL18-607AA and -137GG genotypes showed significant association with higher level of serum AFP. The detection of polymorphisms in the IL-18 promoter, in a combination with an evaluation of level of serum AFP, could be used as a molecular biomarker in the early diagnosis of HCC, which would aid the early management of the disease, thus decreasing the rate of mortality of this disease. © 2018 IUBMB Life, 70(2):165-174, 2018.

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Association analysis of interleukin‐18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women

Qiao

Xu²,

Sun

et al. 2018

Clinical Laboratory Analysis

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Association of –607 C/A Polymorphism of IL-18 Gene (rs1946518) with Breast Cancer Risk in Zahedan, Southeast Iran

Cited by 16 publications

References 14 publications

Interleukin-18 Gene Polymorphism and Some Risk Factors in Iraqi Patients With Breast Cancer

Interleukin-18 Gene Polymorphism and Some Risk Factors in Iraqi Patients With Breast Cancer

Association of genetic variants in the interleukin‐18 gene promoter with risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus infection

Association analysis of interleukin‐18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women

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