2002
DOI: 10.1016/s0376-8716(01)00164-8
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Association of a CB1 Cannabinoid Receptor Gene (CNR1) polymorphism with severe alcohol dependence

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Cited by 143 publications
(108 citation statements)
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References 19 publications
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“…Obesity, schizophrenia, alcohol dependence and striatal responses to happy faces have been associated to one of the four known cb1 SNPs (Russo et al, 2007, Tsai et al, 2000, Martinez-Gras et al, 2007, Schmidt et al, 2002; osteoporosis and systolic/diastolic blood pressure have been associated to cb2 SNPs (Arg528Lys) (Karsak et al, 2005, Yamada et al, 2007; lastly, substance abuse / dependence in Caucasian population, higher body mass index and fat metabolism have been correlated to C385A faah SNP responsible for the missense mutation Pro129Thr (Sipe et al, 2002, Aberle et al, 2007.…”
Section: ) Cloning Of Cb1 In Resculentamentioning
confidence: 99%
“…Obesity, schizophrenia, alcohol dependence and striatal responses to happy faces have been associated to one of the four known cb1 SNPs (Russo et al, 2007, Tsai et al, 2000, Martinez-Gras et al, 2007, Schmidt et al, 2002; osteoporosis and systolic/diastolic blood pressure have been associated to cb2 SNPs (Arg528Lys) (Karsak et al, 2005, Yamada et al, 2007; lastly, substance abuse / dependence in Caucasian population, higher body mass index and fat metabolism have been correlated to C385A faah SNP responsible for the missense mutation Pro129Thr (Sipe et al, 2002, Aberle et al, 2007.…”
Section: ) Cloning Of Cb1 In Resculentamentioning
confidence: 99%
“…10 We used PCR primers F1-F (5 0 -AA GACGGTGTTTGCATTCTG-3 0 ) and THAC-R (5 0 -AAATTCTTTTCCTGTGCTGCCAGGGAG-3 0 ) and allele-specific primers A3-F (5 0 -AGTGAGAGTTGCATCAAGAGCACA-3 0 ) and T1-R (5 0 -GACTTGGCAATCTTGACT-3 0 ) or G4-F (5 0 -AGTGAGAGTTGCATCAAGAGCACG-3 0 ) and C2-R (5 0 -GACTTGGCAATCTTGACC-3 0 ) to detect the polymorphic A-allele or the G-allele, respectively.…”
Section: Genotypingmentioning
confidence: 99%
“…Opioid dependence (Li et al 2000), drug dependence (Covault et al 2001), extreme response to cannabis use (cannabis-induced psychosis) (Hoehe et al 2000), alcohol withdrawal delirium (Schmidt et al 2002), intravenous drug use , and P300 evoked potential have been examined for their association with CNR1. Covault et al (2001) reported no association between a CNR1 microsatellite polymorphism and drug or alcohol dependence.…”
Section: Introductionmentioning
confidence: 99%
“…Hoehe et al (2000) reported no difference in allele frequencies of two silent mutations in the coding region of CNR1 between individuals exhibiting an extreme response to cannabis and a control group. Schmidt et al (2002) reported a positive association between alcohol withdrawal delirium and a silent mutation in the CNR1 receptor (1359 G/A). Comings et al (1997) reported a positive association between a CNR1 microsatellite polymorphism and intravenous drug use as well as cocaine, amphetamine, and cannabis dependence.…”
Section: Introductionmentioning
confidence: 99%