Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Abstract

Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

“…[13][14][15][16][17][18][19] Recent reports have usually demonstrated an inverse association between omentin-1 and atherosclerosis (AS). 18,[20][21][22][23] Little is known about omentin-1 in CKD. It may be implicated in the pathogenesis of CVD in these patients.…”

Adipose‐derived protein omentin prevents neointimal formation after arterial injury

“…Plasma omentin levels are decreased in association with obesity-linked metabolic disorders, including metabolic syndrome, type 2 diabetes, and insulin resistance (9)(10)(11). Recent clinical studies have shown that circulating omentin concentrations are reduced in patients with cardiovascular disorders such as carotid atherosclerosis and coronary artery disease (12)(13)(14)(15). Thus, omentin may be a valuable biomarker for obese complications.…”

Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism

“…Omentin is detectable in human blood stream (100 to 800 ng/ml) (11,12), and circulating omentin levels are decreased in obesity (11). Furthermore, circulating omentin levels are down-regulated in association with obesity-linked disorders, including type 2 diabetes, metabolic syndrome, endothelial dysfunction, carotid atherosclerosis, and coronary artery disease (12)(13)(14)(15)(16). It has been shown that treatment of adipocytes with the omentin protein results in enhancement of glucose uptake (8).…”