Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine

Glubb, Dylan M.; McHugh, Patrick; Deng, Xiaoyan; Joyce, Peter R.; Kennedy, Martin A.

doi:10.1038/tpj.2009.33

Cited by 22 publications

(13 citation statements)

References 49 publications

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“…In a luciferase gene reporter assay, constructs containing the A or the C allele of rs11042725 were transiently transfected into RN46A cells (33). Luciferase gene expression was significantly higher under the control of the A allele (associated in our study with higher plasma MR-proADM Table 4-Plasma MR-proADM at baseline by ADM genotype in DIABHYCAR and SURDIAGENE studies Data are means 6 SEM.…”

Section: Discussionmentioning

confidence: 58%

Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes

et al. 2015

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Production of adrenomedullin (ADM), a vasodilator peptide, increases in response to ischemia and hypoxia in the vascular wall and the kidney. This may be an adaptive response providing protection against organ damage. We investigated the hypothesis that ADM has a nephroprotective effect in two prospective cohorts of patients with type 2 diabetes recruited in France. The highest tertile of plasma MR-proADM (a surrogate for ADM) concentration at baseline was associated with the risk of renal outcomes (doubling of plasma creatinine concentration and/or progression to end-stage renal disease) during follow-up in both cohorts. Four SNPs in the ADM gene region were associated with plasma MR-proADM concentration at baseline and with eGFR during follow-up in both cohorts. The alleles associated with lower eGFR were also associated with lower plasma MR-proADM level. In conclusion, plasma MR-proADM concentration was associated with renal outcome in patients with type 2 diabetes. Our data suggest that the ADM gene modulates the genetic susceptibility to nephropathy progression. Results are consistent with the hypothesis of a reactive rise of ADM in diabetic nephropathy, blunted in risk alleles carriers, and with a nephroprotective effect of ADM. A possible therapeutic effect of ADM receptor agonists in diabetic renal disease would be worth investigating.

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Section: Discussionmentioning

confidence: 58%

Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes

et al. 2015

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“…Genetic variants such as rs11042725 have been reported to have functional effect on the promoter function of ADM (43). The SNP rs4910118 is located at 762 bp downstream of the 3 0 -end of ADM.…”

Section: Discussionmentioning

confidence: 99%

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Cheung

Ong²,

Tso³

et al. 2011

European Journal of Endocrinology

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Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (bZK0.116, PZ0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (PZ0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (bZK0.115, PZ0.011). Haplotype analysis revealed a similar significant association with plasma ADM (PZ0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (PZ0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction.

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“…This same polymorphism has been associated with predisposition to proteinuria in EH and is found with greater frequency in type II diabetic patients in renal failure compared to controls or diabetic patients without nephropathy [91–92]. Specific single nucleotide polymorphisms (SNPs) in AM have also been associated with reduced systolic blood pressure, lower pulse pressure, and reduced urinary sodium excretion in a Chinese population [93], increased risk of developing dysglycemia in a Chinese population [94], and altered response to the antidepressant paroxetine [95]. A particular SNP in the AM receptor gene, CALCRL was found with increased frequency specifically among women with EH in a Japanese population [96], and other studies have found CLR SNPs associated with severe periodontitis [97] and acute primary angle closure glaucoma [98].…”

Section: Adrenomedullin In Pregnancy Complicationsmentioning

confidence: 99%

Adrenomedullin and pregnancy: perspectives from animal models to humans

Lenhart¹,

Caron²

2012

Trends in Endocrinology & Metabolism

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A healthy pregnancy requires strict coordination of genetic, physiologic, and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin has recently been the focus of some exciting breakthroughs in the pregnancy field. Supported by mechanistic studies in genetic animal models, there continues to be a growing body of evidence demonstrating the importance of adrenomedullin protein levels in a variety of human pregnancy complications. With more extensive mechanistic studies and improved consistency in clinical measurements of adrenomedullin, there is great potential for the development of adrenomedullin as a clinically-relevant biomarker in pregnancy and pregnancy complications.

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Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine

Cited by 22 publications

References 49 publications

Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes

Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Adrenomedullin and pregnancy: perspectives from animal models to humans

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