Association of a Genetic Risk Score with BMI Along the Life-Cycle: Evidence from Several Us Cohorts

Sanz-de-Galdeano, Anna; Terskaya, Anastasia; Upegui, Angie

doi:10.2139/ssrn.3691384

Cited by 2 publications

(1 citation statement)

References 40 publications

(51 reference statements)

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“…Work in this area has demonstrated how effects that appear conceptually distinct can be difficult to distinguish when specified in models (Fosse & Winship, 2019). Changes in genetic effects modeled in terms of cohorts (e.g., Briley, Harden, & Tucker-Drob, 2015; Rosenquist et al, 2015; Sanz-de-Galdeano, Terskaya, & Upegui, 2020), for example, might equivalently be framed in terms of periods (e.g., war, socioeconomic conditions, or policy eras) which are often implicitly the focus of explanation anyway. Other research suggests that apparently simple sociological concepts might require relatively complex model features to capture when considered simultaneously against the backdrop of development (Fosse & Winship, 2019).…”

Section: Challenges In the Modeling Of Culture Genes And Environment ...mentioning

confidence: 99%

Cultural evolution and behavior genetic modeling: The long view of time

Markon

Krueger²,

South³

2022

Behav Brain Sci

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We advocate for an integrative long-term perspective on time, noting that culture changes on timescales amenable to behavioral genetic study with appropriate design and modeling extensions. We note the need for replications of behavioral genetic studies to examine model invariance across long-term timescales, which would afford examination of specified as well as unspecified cultural moderators of behavioral genetic effects.

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Section: Challenges In the Modeling Of Culture Genes And Environment ...mentioning

confidence: 99%

Cultural evolution and behavior genetic modeling: The long view of time

Markon

Krueger²,

South³

2022

Behav Brain Sci

View full text Add to dashboard Cite

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Associations of MC4R, LEP, and LEPR Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood

Raskilienė

Smalinskienė

Kriaučionienė

et al. 2021

Genes

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MC4R, LEP, and LEPR genes are involved in the hypothalamic leptin-melanocortin regulation pathway, which is important for energy homeostasis. Our study aimed to evaluate the associations between the MC4R rs17782313, LEP rs7799039, and LEPR rs1137101 polymorphisms with obesity-related parameters in childhood and adulthood. The data were obtained from the Kaunas Cardiovascular Risk Cohort study, which started in 1977 with 1082 participants aged 12–13 years. In 2012–2014, the follow-up survey was carried out. Genotype analysis of all respondents (n = 509) aged 48–49 years was performed for the gene polymorphisms using Real-Time Polymerase Chain Reaction. Anthropometric measurements were performed in childhood and adulthood. In childhood, only skinfold thicknesses were associated with gene variants being the lowest in children with MC4R TT genotype and LEP AG genotype. In adulthood, odds of obesity and metabolic syndrome was higher in MC4R CT/CC genotype than TT genotype carriers (OR 1.8; 95% CI 1.2–2.8 and OR 1.6; 95% CI 1.1–2.4, respectively). In men, physical activity attenuated the effect of the MC4R rs17782313 on obesity. The LEP GG genotype was associated with higher BMI, waist circumference, and visceral fat level only in men. No associations of the LEPR rs1137101 polymorphisms with anthropometric measurements and leptin level were found. In conclusion, the associations of the MC4R and LEP gene polymorphisms with obesity-related parameters strengthened with age.

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Association of a Genetic Risk Score with BMI Along the Life-Cycle: Evidence from Several Us Cohorts

Cited by 2 publications

References 40 publications

Cultural evolution and behavior genetic modeling: The long view of time

Cultural evolution and behavior genetic modeling: The long view of time

Associations of MC4R, LEP, and LEPR Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood

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