Association of a Methylene Tetrahydrofolate Reductase C677T Polymorphism with Several Blood Chemical Levels in a Chinese Population

Wen, Congcong; Lv, Jiao-Feng; Wang, Ling; Zhu, Weixing; Wan, Fu-sheng; Wang, Xiaozhong

doi:10.1089/gtmb.2014.0213

Cited by 14 publications

(10 citation statements)

References 46 publications

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“…Regarding lipid profiles, the MTHFR 677T allele is associated in non-obese patients with unfavourable serum lipid profiles in several studies (15, 18, 21, 24, 26, 28). In this study, we detected low levels of triglycerides and cholesterol in overweight/obese individuals carrying the TT genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the 677T allele has been linked with overweight/obesity risk, dyslipidemias, and diabetes in several populations. However, so far, the studies have been controversial (4, 5, 7, 8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30). Here, we analyzed whether there is an association of the MTHFR 677C>T polymorphism with overweight and obesity, as well as its relationship with lipid profile, glucose level, and anthropometric measurements in a young Mexican population.…”

Section: Introductionmentioning

confidence: 99%

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Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Leal-Ugarte

Peralta-Leal

Meza-Espinoza

et al. 2019

Journal of Medical Biochemistry

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Summary Background Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico. Methods A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C>T polymorphism was performed by the PCR-RFLP method. Results There was no difference in the distribution of the MTHFR 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. Conclusions These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the MTHFR 677C>T polymorphism in overweight, obesity, and lipid profile level.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Leal-Ugarte

Peralta-Leal

Meza-Espinoza

et al. 2019

Journal of Medical Biochemistry

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“…Many previous studies have explored the relationship between the MTHFR C677T polymorphism and serum or plasma lipid profiles in humans, with some indicating that the T allele was associated with unfavourable lipid profiles [8–11, 17, 36–39], whereas the others reported null association [40–43]. An interesting study by Zhang et al indicated that the MTHFR 677 T allele significantly increases the serum levels of TC and LDL-C in both Chinese Bai Ku Yao and Han populations [10].…”

Section: Discussionmentioning

confidence: 99%

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

et al. 2016

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BackgroundLittle is known regarding the interactions of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with overweight/obesity on serum lipid profiles. The aim of the current study was to explore interactions between the two polymorphisms and overweight/obesity on four common lipid levels in a Chinese Han population and further to evaluate whether these interactions exhibit gender-specificity.MethodsA total of 2239 participants (750 females and 1489 males) were enrolled into this study. The genotypes of the MTHFR C677T and MTRR A66G were determined by a TaqMan assay. Overweight and obesity were defined as a body mass index between 24 and 27.99 and ≥ 28 kg/m2, respectively. The interactions were examined by factorial design covariance analysis, and further multiple comparisons were conducted by Bonferroni correction.ResultsThere was no significant difference in the genotypic and allelic frequencies between females and males (MTHFR 677 T allele: 54.47 % for females and 54.40 % for males; MTRR 66G allele: 24.73 % for females and 24.71 % for males). Interaction between the MTHFR C677T polymorphism and overweight/obesity on serum triglyceride levels, and interaction between the MTRR A66G polymorphism and overweight/obesity on serum high-density lipoprotein cholesterol levels were detected in women (P = 0.015 and P = 0.056, respectively). For female subjects with overweight/obesity, the serum triglyceride levels in MTHFR 677TT genotype [1.09 (0.78–1.50) mmol/L] were significantly higher as compared with MTHFR 677CC genotype [0.90 (0.60–1.15) mmol/L, P = 0.007], and the MTRR 66GG genotype carriers had higher serum high-density lipoprotein cholesterol levels than those with MTRR 66AG genotype (1.46 ± 0.50 vs. 1.19 ± 0.31 mmol/L, P = 0.058). Furthermore, in male subjects with overweight/obesity, the MTHFR 677CT genotype carriers had higher low-density lipoprotein cholesterol levels than those with MTHFR 677TT genotype (2.96 ± 1.07 vs. 2.74 ± 0.88 mmol/L, P = 0.015).ConclusionsOur results indicate that there exist interactive effects of the MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on some lipid traits in Chinese Han population, and the effects were gender-specific.

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“…MTHFR rs1801133 C/T genotype may be a risk factor of hypertension in a Caucasian population [ 44 ]. People carried MTHFR rs1801133 T allele enhanced the risk of hypertension among Chinese in Taiwan [ 45 ], Chinese Han population in Shihezi city, Xinjiang Province, China [ 46 ], Chinese from Jiangxi Province [ 47 ], and male Spaniard [ 48 ]. DBP and SBP levels of female hypertensive patients were different among the different genotypes of MTHFR in the Baiku Yao population in China [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Association of ALDH2 rs671 and MTHFR rs1801133 polymorphisms with hypertension among Hakka people in Southern China

Huang

et al. 2022

BMC Cardiovasc Disord

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Background Genetic factors play an important role in susceptibility to hypertension. Herein, the association between acetaldehyde dehydrogenase 2 (ALDH2) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hypertension was analyzed among Hakka population in southern China. Methods A total of 3057 hypertensive patients and 2215 controls were enrolled. The ALDH2 rs671 and MTHFR rs1801133 genotyping were analyzed using gene chip. Relevant information and medical records of these subjects were collected. Results Hypertensive patients with ALDH2 rs671 G/A heterozygous had lower systolic blood pressure (SBP) than other genotypes (P < 0.001), while hypertensive patients with A allele had lower diastolic blood pressure (DBP) than patients with G allele (P < 0.001). The level of plasma homocysteine (Hcy) in patients with MTHFR CC, CT and TT genotypes showed an increasing trend (P < 0.001). The ALDH2 G/A genotype in the co-dominant model (adjusted OR 1.251, 95% CI 1.024–1.528, P = 0.028) and ALDH2 A/A genotype in the recessive model (adjusted OR 1.221, 95% CI 1.008–1.478, P = 0.041) were significant risk factors for the presence of hypertension. The MTHFR C/T genotype in the co-dominant model (adjusted OR 1.307, 95% CI 1.039–1.643, P = 0.022) and MTHFR C/T and T/T genotypes in the dominant model (adjusted OR 1.281, 95% CI 1.146–1.430, P < 0.001) were significant risk factors for the presence of hypertension. Further, logistic regression analysis showed that age, smoking, alcohol consumption, hyperhomocysteinemia, and high level of serum TG, Apo-A1, Apo-B were significant risks for hypertension. Conclusions In summary, ALDH2 rs671 G/A, A/A genotypes and MTHFR rs1801133 C/T, T/T genotypes may be risk factors for hypertension in this Chinese Hakka population.

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Association of a Methylene Tetrahydrofolate Reductase C677T Polymorphism with Several Blood Chemical Levels in a Chinese Population

Abstract: Our data demonstrate that the MTHFR C677T polymorphism is positively correlated with an increased risk of hypertension through an increase in HCY levels. The blood lipid correlative index was different between male and female hypertension patients and controls.

Cited by 14 publications

References 46 publications

Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

Association of ALDH2 rs671 and MTHFR rs1801133 polymorphisms with hypertension among Hakka people in Southern China

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