Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder

Roohi, Jasmin; DeVincent, Carla J.; Hatchwell, Eli; Gadow, Kenneth D.

doi:10.1007/s10803-008-0600-8

Cited by 37 publications

(40 citation statements)

References 47 publications

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“…Since the activation status of the MAO-A gene on the X chromosome is unknown in females, inferences about MAO-A activity cannot be unambiguously determined (Carrel and Willard 2005;Kim-Cohen et al 2006). Thus, we only examined boys in our example (n=150), which is consonant with the extant literature for studies of MAO-A and psychopathology (Kim-Cohen et al 2006;Roohi et al 2009). …”

Section: Methodsmentioning

confidence: 72%

“…However, we emphasize that the exact role of MAO-A genotype on the pathogenesis of ADHD (and other disorders) has not been authoritatively established. Neurobiological consequences of variation in MAO-A genotype is, at this point, speculative (Roohi et al 2009). Contrasting findings, as those reported here, may suggest that MAO activity in the brain may not correspond exclusively to the particular MAO-A genotype we examined (Fowler et al 2007) given the possibility of linkage disequilibrium (LD).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, MAO-A knockout mice exhibit increased neural monoamine, resulting in ADHD-spectrum phenotypes (Cases et al 1995). There is evidence that the high-activity MAO-A genotype is associated with ADHD (Manor et al 2002;Roohi et al 2009) whereas Xu et al (2007) and Das et al (2006) found that the lowactivity genotype was over-transmitted to ADHD probands. Finally, null associations between MAO-A and ADHD have also been reported (Lawson et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Lee

2011

J Abnorm Child Psychol

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Relatively little is known about the potential interplay between genetic and environmental influences on attention-deficit/hyperactivity disorder (ADHD), including gene-environment interaction (G×E). There is evidence that parenting behavior interacts with offspring genotype in the development of externalizing problems, but studies have largely focused on explicit maltreatment rather than differentiated measures of parenting behavior, including positive and negative parenting. We tested the interactive effects of the 30-base pair variable number tandem repeat (VNTR) polymorphism of the monoamine oxidase A gene (MAO-A) with positive and negative parenting behavior on parent- and teacher ratings of inattention and hyperactivity symptoms among 150 6-9 year-old boys with and without ADHD. Negative parenting predicted parent and teacher ratings of inattention symptoms, but only among boys with high-activity MAO-A genotype. MAO-A genotype did not moderate the association of positive parenting and parent- and teacher ratings of ADHD. We discuss the potential role of interactive exchanges between parenting behavior and child genotype in the development and persistence of ADHD and related behavior problems.

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Section: Methodsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Lee

2011

J Abnorm Child Psychol

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“…Preliminary evidence implicates several genes associated with risk for anxiety in ASD. These include the dopamine transporter gene ( DAT1 , [51]), D4 receptor gene [52], MAO-A gene [53,54], glutamate transporter gene ( SLC1A1 , [55]). Sample sizes in these genetic studies as well as the aforementioned family studies are small and therefore the results must be viewed as preliminary.…”

Section: Risk Factors and Correlates Of Anxiety In Autism Spectrum DImentioning

confidence: 99%

An update on anxiety in youth with autism spectrum disorders

Vasa

Mazurek

2015

Current Opinion in Psychiatry

104

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Purpose of review Anxiety is one of the most common co-occurring psychiatric conditions in youth with autism spectrum disorders (ASDs). This article reviews recent evidence as well as earlier relevant studies regarding the characteristics, assessment, and treatment of anxiety in youth with ASD. Recent findings It is well established that the prevalence of anxiety in youth with an ASD is significantly greater than the prevalence of anxiety in the general population. Recent studies have highlighted the importance of informant, method, and instrument when measuring anxiety in this population. Despite the high prevalence, findings to date have been unable to identify any consistent risk factors for anxiety. New psychological treatments, including modified cognitive behavioral therapy for youth with high functioning ASD and co-occurring anxiety, are emerging. Pharmacological data, however, are scant. Existing studies show that youth with ASD are at increased risk for behavioral activation when taking SSRIs. Summary Clinicians working with youth with ASD are encouraged to routinely screen for anxiety. Until further data are available, clinical judgment is needed when prescribing treatments, particularly selective serotonin reuptake inhibitors, which require close monitoring of side-effects. Research on risk factors, pathophysiology, and treatment of this condition is needed.

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“…A later study examined the severity of ADHD and anxiety symptoms in a sample of 5 to 14 year-old Caucasian boys with ASD (n = 43) and reported that ASD children with the 4-repeat allele had a more severe parent-rated inattention and impulsivity, and more teacher-rated symptoms of generalized anxiety 17 .…”

Section: Autism Spectrum Disorders (Asd)mentioning

confidence: 99%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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Introduction: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. Objective: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. Method: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: "MAOA and human behavior" and "MAOA and psychiatry". Results: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. Discussion: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior ("hyperactive behaviors"), and the high activity alleles of the gene with "hypoactive behaviors", such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in "hyperactive" and "hypoactive" disorders.

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Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder

Cited by 37 publications

References 47 publications

Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

An update on anxiety in youth with autism spectrum disorders

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

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