Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations

Yamada, Yoshiji; Nishida, Tamotsu; Ichihara, Sahoko; Sawabe, Motoji; Fuku, Noriyuki; Nishigaki, Yutaka; Aoyagi, Yukitoshi; Tanaka, Masashi; Fujiwara, Yoshinori; Yoshida, Hiroto; Shinkai, Shoji; Satoh, Kei; Kato, Koichi; Fujimaki, Tetsuo; Yokoi, Kiyoshi; Oguri, Mitsutoshi; Yoshida, Tetsuro; Watanabe, Soichi; Nozawa, Yoshinori; Hasegawa, Asako; Kojima, Toshio; Han, Bok Ghee; Ahn, Younjin; Lee, Meehee; Shin, Dong Jik; Lee, Jong Ho; Jang, Yangsoo

doi:10.1016/j.atherosclerosis.2010.12.005

Cited by 46 publications

(82 citation statements)

References 20 publications

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“…The butyrophilin, subfamily 2, member A1 (BTN2A1) belongs to BTN superfamily, and is a cell surface transmembrane glycoprotein that has roles in lipid, fatty acid, and sterol metabolism (Entrez Gene, NCBI). We previously showed that the T allele of rs6929846 of BTN2A1 was associated with an increased risk for myocardial infarction, an increase in the serum concentration of high sensitivity C-reactive protein as well as with increased transcription activity of BTN2A1 (20). Overexpression of BTN2A1 decreased the expression of elastin mRNA and increased the mRNA expression of matrix metallopeptidase 3 and interleukin 5 (20).…”

Section: Discussionmentioning

confidence: 99%

“…Genotyping involved PCR amplification, hybridization, streptavidin-phycoerythrin reaction, and measurement of fluorescence. Detailed genotyping methodology was previously described (12,20,21).…”

Section: Methodsmentioning

confidence: 99%

“…Genotypes of rs662799 of APOA5 and rs6929846 of BTN2A1 were determined with the use of a TaqMan fluorogenic 5' nuclease assay (Applied Biosystems, Foster City, CA). Genotyping methodology was previously described (20,22).…”

Section: Methodsmentioning

confidence: 99%

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Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Hiramatsu

Oguri²,

Kato

et al. 2012

Int J Mol Med

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Abstract. We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals. The purpose of the present study was to examine whether these polymorphisms synergistically affect the prevalence of dyslipidemia and MetS in East Asian populations. The study populations comprised 7471 Japanese and 3529 Korean individuals in the dyslipidemia study, and 3474 Japanese and 1671 Korean individuals in the MetS study. Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia. Japanese or Korean individuals with the C allele of APOA5 and the T allele of BTN2A1 had a 2.05-or 1.92-fold increased risk for hypertriglyceridemia and a 1.82-or 1.56-fold increased risk for hypo-HDL-cholesterolemia, respectively, compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Similar analysis with adjustment for age and gender revealed that Japanese individuals, but not Korean individuals, with the C allele of APOA5 and the T allele of BTN2A1 had a 2.87-fold increased risk for MetS compared to those with the TT genotype of APOA5 and the CC genotype of BTN2A1. Genetic variants of APOA5 and BTN2A1 may synergistically affect the prevalence of dyslipidemia in East Asian populations and of MetS in Japanese individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Hiramatsu

Oguri²,

Kato

et al. 2012

Int J Mol Med

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“…We previously showed that the c→T polymorphism (rs6929846) of BTN2A1 and the a→G polymorphism (rs2569512) of ILF3 were significantly associated with MI in Japanese individuals by a genome-wide association study (4). The T allele of rs6929846 increased the transcription activity of BTN2A1 and the over-expression of BTN2A1 decreased the expression of elastin mrna and increased the mrna expression of matrix metallopeptidase 3 and interleukin 5 in human cell cultures (4).…”

Section: Discussionmentioning

confidence: 99%

“…We also showed that the C→T polymorphism (rs6929846) of BTN2A1 and the a→G polymorphism (rs2569512) of ILF3 were significantly associated with MI in Japanese individuals by a genome-wide association study (4). To further examine whether the association of polymorphisms…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles

Yamada¹

2011

Mol Med Rep

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Abstract. dyslipidemia is an important risk factor for myocardial infarction (Mi). We previously showed that gene polymorphisms associated with Mi differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals. in the present study, we examined the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and Mi in individuals with low or high serum concentrations of triglycerides, high density lipoprotein (Hdl) cholesterol, or low density lipoprotein (ldl) cholesterol, respectively. The study population comprised 5513 unrelated Japanese individuals, including 1537 subjects with Mi and 3976 controls. Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with Mi in individuals with low (P=3.1x10 -5 ; odds ratio, or=1.66) or high (P=1.1x10 -6 ; or=2.09) triglycerides; in individuals with low (P=0.0082; or=1.75) or high (P=2.0x10 -9 ; or=1.85) Hdl cholesterol; and in individuals with low (P=3.2x10 -7 ; or=1.75) or high (P=2.8x10 -5 ; or=2.18) ldl cholesterol. Similar analyses revealed that rs2569512 of ILF3 was significantly associated with MI in individuals with low (P=0.0066; or=1.47) or high (P=0.0013; or=1.88) triglycerides; in individuals with low (P=0.0059; or=1.96) or high (P=0.0020; or=1.51) Hdl cholesterol; and in individuals with low (P=0.0004, or=1.62) ldl cholesterol, but not in those with high ldl cholesterol. The results suggest that the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI is influenced by the serum concentrations of HDL and LDL cholesterol, respectively. Stratification of subjects according to lipid profiles may thus be useful for the personalized prevention of Mi based on genetic information.

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Molecular Genetics of Coronary Artery Disease

Ozaki¹

2017

Encyclopedia of Life Sciences

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Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations

Cited by 46 publications

References 20 publications

Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles

Molecular Genetics of Coronary Artery Disease

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