Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus

Abstract

Abstract. hypertension and diabetes mellitus are important risk factors for chronic kidney disease (cKd). We previously showed that the c→t polymorphism (rs6929846) of BTN2A1 was significantly associated with myocardial infarction. The purpose of the present study was to examine an association of rs6929846 of BTN2A1 with cKd in individuals with or without hypertension or diabetes mellitus, thereby contributing to the personalized prevention of cKd in such individuals separately. the study population comprised 7,542 unrelated individuals, including 2,289 subjects with CKD [estimated glomerular filtration rate (eGFr) <60 ml/min/1.73 m 2 ] and 5,253 controls (eGFr ≥60 ml/min/1.73 m 2 ) with or without hypertension or diabetes mellitus. the chi-square test, a multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that the c→t polymorphism (rs6929846) of BTN2A1 was significantly associated with cKd in normotensive individuals, in diabetic individuals and in individuals with hypertension and diabetes mellitus, or without either condition, with the T allele representing a risk factor for CKD. Stratification of subjects based on hypertension or diabetes mellitus may thus be important in order to achieve personalized prevention of cKd with the use of genetic information. Introduction chronic kidney disease (cKd) is an important global public health problem because of its high morbidity in the general population. recent studies suggest that the risk for death is increased in individuals who have impaired renal function, but do not require dialysis, compared to those who have preserved renal function (1,2). disease prevention is an important strategy for reducing the overall burden of cKd and end-stage renal disease (ESRD), and the identification of markers for cKd risk is essential both for risk prediction and for potential intervention to reduce the chance of future cardiovascular complications (3).Several risk factors for progression of cKd have been proposed (4), with hypertension and diabetes mellitus having been recognized as important risk factors for cKd (5-7) as well as for coronary heart disease and stroke. in addition to these conventional risk factors, recent studies have shown the importance of genetic factors and of interactions between multiple genes and environmental factors in the development of cKd (8,9). although recent genome-wide association studies (GWaSs) (10-15) have implicated several loci and candidate genes in predisposition to cKd or ESrd in caucasians or african-american populations, the genes that contribute to genetic susceptibility to cKd in asian populations remain to be identified definitively. Gifu prefectural General medical center, Gifu; 8 department of Vascular biology, institute of brain Science, hirosaki university Graduate School of medicine, hirosaki; 9 department of Genomics for longevity and health, and 10 research team for Social participation and health promotion, tokyo metropolitan institute of Gero...

Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family

“…Additionally, association studies in human show that genes like BTN3A2 are polymorphic with some SNP that are related to susceptibility to diseases like type 1 diabetes (14). Similarly, the polymorphism of other BTN such as BTN2A1 is related to susceptibility to type 2 diabetes (15), chronic kidney disease (16,17), metabolic syndrome (18), dyslipidemia (19) or myocardial infarction Moreover (20,21). A recent study has described the association of the polymorphism of the 3A3-2A1 region with rubella virus-specific cellular immunity following vaccination (22).…”

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

“…In a series of reports from the research group of Prof. Yoshiji Yamada at Inabe General Hospital (Japan) a link has been found between the polymorphisms of the BTN2A1 gene and several medical symptoms and deficiencies [ 81 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 ]. In fact, in these studies, the C-T polymorphism of the BTN2A1 gene allele was significantly associated with the myocardial infarction [ 169 , 170 ], dislipidema [ 171 , 172 , 173 ], chronic kidney diseases (CKD) [ 172 , 174 , 175 , 176 ], hypertension [ 177 , 178 , 179 ], type 2 diabetes mellitus [ 81 ], and metabolic syndrome [ 180 ] in Japanese individuals and in East Asian populations.…”