Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition

Nkrumah, J. D.; Li, C.; Basarab, J. B.; Guercio, S.; Meng, Ying‐Ying; Murdoch, Brenda M.; Hansen, C.; Moore, S. S.

doi:10.4141/a03-033

Cited by 84 publications

(80 citation statements)

References 33 publications

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“…Confirmations for the calpain and calpastatin genes have been reported by several authors (Page et al, 2004;Casas et al, 2006;Morris et al, 2006;Schenkel et al, 2006). For marbling several of the genes have been confirmed in some studies while in others some tests have failed to be confirmed (Thaller et al, 2003;Nkrumah et al, 2004;Barendse et al, 2005;Kononoff et al, 2005;Nkrumah et al, 2005;Pollak, 2005;Schenkel et al, 2005;Barendse et al, 2006;Rincker et al, 2006). Marbling is a more difficult trait to work with than tenderness, since it is a visual inspection of the carcass and hence is a measurement with a greater error, which means that it will require larger samples than normal to be detected.…”

Section: Bovine Genome Sequencing and Applications For Breedingmentioning

confidence: 94%

Recent advances in cattle functional genomics and their application to beef quality

Hocquette

Lehnert

Barendse

et al. 2007

Animal

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The advent of high-throughput DNA sequencing techniques, array technology and protein analysis has increased the efficiency of research in bovine muscle physiology, with the ultimate objective of improving beef quality either by breeding or rearing factors. For genetic purposes, polymorphisms in some key genes have been reported for their association with beef quality traits. The sequencing of the bovine genome has dramatically increased the number of available gene polymorphisms. The association of these new polymorphisms with the variability in beef quality (e.g. tenderness, marbling) for different breeds in different rearing systems will be a very important issue. For rearing purposes, global gene expression profiling at the mRNA or protein level has already shown that previously unsuspected genes may be associated either with muscle development or growth, and may lead to the development of new molecular indicators of tenderness or marbling. Some of these genes are specifically regulated by genetic and nutritional factors or differ between different beef cuts. In recognition of the potential economic benefits of genomics, public institutions in association with the beef industry are developing livestock genomics projects around the world. From the scientific, technical and economical points of view, genomics is thus reshaping research on beef quality.

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Section: Bovine Genome Sequencing and Applications For Breedingmentioning

confidence: 94%

Recent advances in cattle functional genomics and their application to beef quality

Hocquette

Lehnert

Barendse

et al. 2007

Animal

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“…This allele had a higher frequency in British breeds compared to Continental breeds (0.58 in Angus, 0.34 in Charolais). Later, Nkrumah et al (2004) reported an association of the T allele with higher carcass grades but lower carcass lean percentage, with no effect on feed intake or feed efficiency. In a sample of crossbred steers with varied genetic background, the frequency of T was between 0.42 and 0.71.…”

Section: Association Analysismentioning

confidence: 99%

“…Another interesting feature of SNP2 is the type of gene action. For many composition and quality traits, relative comparisons among genotypic classes have shown no consistent distinction between additivity and dominance (Nkrumah et al, 2004;Schenkel et al, 2005;Di Stasio et al, 2007).…”

Section: Association Analysismentioning

confidence: 99%

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Effect of leptin gene polymorphisms on growth, slaughter and meat quality traits of grazing Brangus steers

Corva

Macedo²,

Soria³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. Leptin is a hormone that affects the regulation of feed intake, energy balance and body composition in mammals. Several polymorphisms in the bovine leptin gene have been associated with phenotypic variance of these traits. We evaluated two known single nucleotide polymorphisms (SNPs) in the leptin gene of 253 grazing Brangus steers. Brangus is a 5/8 Angus-3/8 Brahman composite. Data were collected during two consecutive growth/fattening cycles from two farms in southeast Buenos Aires province, Argentina. One of the markers is in the promoter region of the gene (SNP1) and the other is a non-synonymous polymorphism in exon 2 (SNP2). The traits that we evaluated were live weight gain in the spring, gain in backfat thickness in the spring, final live weight, final ultrasound backfat thickness, final ultrasound rib eye area, carcass weight and length, carcass yield, kidney fat, kidney fat percentage, backfat thickness, rib eye area, and intramuscular fat percentage. Both markers affected some meat traits; though the only significant associations were of SNP1 with ultrasound rib eye area and of SNP2 with carcass yield and backfat thickness. Under the same conditions as in the present study, leptin markers could be of help only as part of a larger genotyping panel including other relevant genes.

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“…Some genetic markers are associated with important economical traits of livestock species; via marker-assisted selection, the identification of the marker has the potential to alter the genetic improvement rate (Nkrumah et al, 2003). The genes associated with adult height have been identified and provided important insights to analyze the genetics of polygenic quantitative traits (Weedon et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle

Fu¹,

Tian²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Body measurement and meat quality traits play important roles in the evaluation of productivity and economy in cattle, which are influenced by genes and environmental factors. PRKAG2, which encodes the γ2 regulatory subunit of AMPK, is associated with key metabolic pathways in muscle. We detected bovine PRKAG2 gene polymorphisms and analyzed their associations with body measurement and meat quality traits of cattle. DNA samples were taken from 578 Qinchuan cattle aged 18-24 months. DNA sequencing, polymerase chain reaction-restriction fragment length polymorphism, and timeof-flight mass spectrometry were used to detect PRKAG2 single nucleotide polymorphisms (SNPs). Sequence analysis revealed three SNPs in exon 3 (g.95925G>A, g.95973G>C, and g.95992A>G) and (2015) one g.96058T>C mutation in intron 3. g.95973G>C, g.95992A>G, and g.96058T>C each showed 3 genotypes: GG, GC, and CC; AA, AG, and GG; and TT, TC, and CC, respectively. In contrast, g.95925G>A only showed 2 genotypes, GG and GA. Analysis showed that g.95925G>A had no effects on body measurement and meat quality traits, whereas the other 3 polymorphisms were significantly associated with some of the body measurement and meat quality traits in the Qinchuan cattle population. It is inferred that the PRKAG2 gene can be used for markerassisted selection to improve the body measurement and meat quality traits in the Qinchuan cattle population.

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Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition

Cited by 84 publications

References 33 publications

Recent advances in cattle functional genomics and their application to beef quality

Recent advances in cattle functional genomics and their application to beef quality

Effect of leptin gene polymorphisms on growth, slaughter and meat quality traits of grazing Brangus steers

Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle

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