Association of a single nucleotide polymorphism in the <i>akirin 2</i> gene with economically important traits in <scp>K</scp>orean native cattle

Kim, H.; Lee, S. K.; Mi, Hong; Park, Seok‐Rae; Lee, Y. S.; Kim, J. W.; Lee, H. K.; Jeong, Dalsang; Song, Young-Han; Lee, S. J.

doi:10.1111/age.12055

Cited by 24 publications

(25 citation statements)

References 21 publications

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“…However, none of these has been associated with variations in androstenone levels. This is in contrast to new results indicated that single nucleotide polymorphisms in the full-length gene have an impact on the accumulation of androstenone in Duroc pigs [120]. …”

Section: The Boar Taint Phenomenoncontrasting

confidence: 90%

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review

Rasmussen

Ekstrand

Zamaratskaia

2013

IJMS

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This review focuses on the expression and regulation of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids and xenobiotics is more obscure. Based on currently available literature covering humans, rodents and pigs, this review provides an overview of the present knowledge concerning the regulatory mechanisms for 3β-HSD at all omic levels. The HSD isoenzymes are essential in steroid hormone metabolism, both in the synthesis and degradation of steroids. They display tissue-specific expression and factors influencing their activity, which therefore indicates their tissue-specific responses. 3β-HSD is involved in the synthesis of a number of natural steroid hormones, including progesterone and testosterone, and the hepatic degradation of the pheromone androstenone. In general, a number of signaling and regulatory pathways have been demonstrated to influence 3β-HSD transcription and activity, e.g., JAK-STAT, LH/hCG, ERα, AR, SF-1 and PPARα. The expression and enzymic activity of 3β-HSD are also influenced by external factors, such as dietary composition. Much of the research conducted on porcine 3β-HSD is motivated by its importance for the occurrence of the boar taint phenomenon that results from high concentrations of steroids such as androstenone. This topic is also examined in this review.

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Section: The Boar Taint Phenomenoncontrasting

confidence: 90%

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review

Rasmussen

Ekstrand

Zamaratskaia

2013

IJMS

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“…In recent years, with the significant expansion of the genomic sequence data in many aquaculture species, more and more studies have focus on the identification of SNPs in aquaculture species (Hayes, Laerdahl, Lien, Moen, Berg, Hindar, Davidson, Koop, Adzhubei & Høyheim 2007;Ciobanu, Bastiaansen, Magrin, Rocha, Jiang, Yu, Geiger, Deeb, Rocha, Gong, Kinghorn, Plastow, Van der Steen & Mileham 2010;Li, He, Yang, Shan, Tan & Gao 2010;Van Bers, Crooijmans, Groenen, Dibbits & Komen 2012). However, the association studies between the SNPs and the production traits for most aquaculture species, especially for the Chinese mitten crab, are still limited comparing with that in other domestic animals (Clop, Marcq, Takeda, Pirottin, Tordoir, Bib e, Bouix, Caiment, Elsen, Eychenne, Larzul, Laville, Meish, Milenkovic, Tobin, Charlier & Georges 2006;Daga et al 2013;Glatzer et al 2013;Kim et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Identification of SNPs in the 5′-flanking region and 3′-UTR of theMIHgene and their association with precocity of the Chinese mitten crabEriocheir sinensis

Tang

et al. 2014

Aquac Res

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Moult-inhibiting hormone (MIH), an important regulator of steroidogenesis, inhibits the synthesis of ecdysteroid in Y-organ (YO) and plays a significant role in the regulation of moulting and postembryonic development of crustacean. Because unsuccessful moulting have been widely observed in precocious crabs, we investigated whether genetic variants in the 5 0 -flanking region and 3 0 -untranslated region (3 0 -UTR) of the MIH gene are associated with precocity of the Chinese mitten crab. Thirty individual DNA samples were sequenced to search for SNPs in the 5 0 -flanking region and 3 0 -UTR of the MIH gene. Five SNPs (g.196 T>A, g.230 C>T, g.305 T>C, g.323 C>A and g.372 C>T) in the 5 0 -flanking region and 6 SNPs (g.2677 C>T, g.2759 T>A, g.2807 T>C, g.3042 A>G, g.3088 T>G and g.3295 T>G) in the 3 0 -UTR of the MIH gene were selected for the individual genotyping in a two-stage association study. We found that a SNP g.3088 T>G in the 3 0 -UTR of MIH gene was consistently associated with precocity of the Chinese mitten crab in stage 1 and stage 2, with a per-allele OR (Odds Ratio) of 1.469 (95% CI: 1.169-1.844) after two stages combined (P = 0.001). However, no significant associations were observed between the other 10 SNPs and precocity of the Chinese mitten crab. To our best knowledge, this is the first association study between various SNP genotypes and phenotype attributes in Chinese mitten crab. Our findings suggest that the SNP g.3088 T>G may be a candidate marker for effective marker-assisted selection to decrease the precocity of the Chinese mitten crab in future studies.

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“…Thus, these genes could be considered as important candidate genes for growth-related traits in beef cattle. Furthermore, the c.*188G > A single nucleotide polymorphism (SNP) in AKIRIN2, the g.231054C > T SNP in TTN, the g.1471620G > T SNP in EDG1, and the g.70014208A > G SNP in the MYBPC1 genes showed associations of these SNPs with growth-related traits in JB [13][14][15][16][17][18] and Korean native (KN) [19] cattle. However, the relationships of these SNPs with growth-related traits in Chinese cattle breed have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

SNPs in AKIRIN2, TTN, EDG1 and MYBPC1 genes are associated with growth-related traits in Chinese Qinchuan cattle

Chen

Zhao

et al. 2020

Preprint

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Growth performances are the main breeding objectives in Chinese beef cattle. The objective of this study was to confirm genetic effects of the c.*188G > A SNP in AKIRIN2, the g.231054C > T SNP in TTN, the g.1471620G > T SNP in EDG1, and the g.70014208A > G SNP in MYBPC1 gene on growth-related traits in Chinese Qinchuan cattle, as well as to compare the frequencies of the well-characterized alleles of these SNPs among six Chinese cattle populations, three Japanese cattle populations, two European cattle populations and one Korean cattle breed. In this study, a total of 655 cattle samples were genotyped using MassARRAY and PCR-RFLP. Association analysis indicated that the four SNPs have effects one to six indexes of growth-related traits including body length, wither height, hip height, hip width, rump length, chest depth and chest circumference in Chinese Qinchuan cattle (P < 0.05 to P < 0.001). The well-characterized A (c.*188G > A), T (g.231054C > T) and T (g.1471620G > T) alleles in Japanese Black cattle were significantly higher than Chinese cattle breeds, on the contrary, the G allele (g.70014208A > G) was markedly higher in Chinese cattle breeds than other cattle breeds. These results suggest that the four SNPs might be useful as a molecular marker for growth-related traits in Chinese Qinchuan cattle.

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Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle

Cited by 24 publications

References 21 publications

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review

Identification of SNPs in the 5′-flanking region and 3′-UTR of theMIHgene and their association with precocity of the Chinese mitten crabEriocheir sinensis

SNPs in AKIRIN2, TTN, EDG1 and MYBPC1 genes are associated with growth-related traits in Chinese Qinchuan cattle

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