Association of a Tobacco-specific Nitrosamine Carcinogen with Urinary Cotinine, Urinary Sodium Excretion, and Total Energy Intake in Adolescents and Children

Choi, Jong Weon; Fujii, Tatsuyoshi; Fujii, Noriyoshi

doi:10.1007/s11596-021-2343-0

Cited by 2 publications

(1 citation statement)

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“…Urine cotinine was examined in all subjects aged 6 years and above at the health checkup, and NNAL was randomized in half of the health checkup subjects 30 . Fresh urine samples were collected and immediately underwent routine urinalysis, and the remaining aliquots were stored at –20 °C until the analysis of cotinine and NNAL 33 . Urine concentrations of cotinine and total NNAL (free NNAL plus NNAL-glucuronide) were analyzed by liquid chromatography-tandem mass spectrometry (LC–MS/MS) using Agilent 1100 Series API 4000 (AB Sciex, Foster City, CA, USA) and Agilent 1200 Series Triple Quadrupole 5500 (AB Sciex, Foster City, CA, USA), respectively 34 , 35 .…”

Section: Variablesmentioning

confidence: 99%

Short-term smoking increases the risk of insulin resistance

Cho

Jeong

Shin

et al. 2022

Sci Rep

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Insulin resistance can be affected directly or indirectly by smoking. This cross-sectional study aimed at examining the association between smoking patterns and insulin resistance using objective biomarkers. Data from 4043 participants sourced from the Korea National Health and Nutrition Examination Survey, conducted from 2016 to 2018, were examined. Short-term smoking patterns were used to classify participants according to urine levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and cotinine as continuous-smokers, past-smokers, current-smokers, and non-smokers. Insulin resistance was calculated using the triglyceride-glucose index from blood samples and was defined as either high or low. Multiple logistic regression analysis was performed to investigate the association between smoking behavior and insulin resistance. Men and women who were continuous-smokers (men: odds ratio [OR] = 1.74, p = 0.001; women: OR = 2.01, p = 0.001) and past-smokers (men: OR = 1.47, p = 0.033; women: OR = 1.37, p = 0.050) were more likely to have high insulin resistance than their non-smoking counterparts. Long-term smokers (≥ 40 days) are at an increased risk of insulin resistance in short-term smoking patterns. Smoking cessation may protect against insulin resistance. Therefore, first-time smokers should be educated about the health benefits of quitting smoking.

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Section: Variablesmentioning

confidence: 99%