Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer

Behboodi, Negin; Farazestanian, Marjaneh; Rastgar‐Moghadam, Azam; Mehramiz, Mehrane; Karimi, Ehsan; Rajabian, Majid; Rahmani, Farzad; Khorrami, Shadi; Jafarian, Amir Hossein; Sharifi-Sistani, Noorieh; Avan, Amir; Hasanzadeh, Malihe

doi:10.1007/s11033-021-06185-4

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Wang et al, (2012) in meta-analysis based 27 studies showed that both TNF-α -238 and -308 G/A polymorphisms could be used to identity individual with elevated susceptibility to cervical cancer in by ethnicity (Bi, 2014). Behboodi et al, (2021) in a study among 153 Iranian cervical cancer cases and 292 free cancer subjects demonstrated that TNF-α rs1800629 was associated with increased level and risk of developing cervical cancer. However, Duvlis et al, (2020) reported that TNF-a-238G/A and TNF-a-308 G/T polymorphisms were not associated with the risk of HPV associated cervical intraepithelial lesions or cervical cancer cases in Macedonian women compared to controls.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Parsaeian

Asadian

Karimi-Zarchi

et al. 2021

Asian Pac J Cancer Prev

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Background:In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. Methods: The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software. Results: A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated. Conclusion: The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

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Section: Discussionmentioning

confidence: 99%

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Parsaeian

Asadian

Karimi-Zarchi

et al. 2021

Asian Pac J Cancer Prev

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“…According to Sha et al [39], serum levels of TNFin CC patients were noticeably elevated before surgical intervention, and they then went back to normal. A genetic variant of the TNF-α gene (rs1800629) was linked to higher levels and risks of developing CC, according to research by Behboodi et al [40].…”

Section: Discussionmentioning

confidence: 99%

A novel pyroptosis-related gene signature for predicting the prognosis of cervical cancer

2024

EJGO

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Although morbidity has decreased in developed regions, cervical cancer (CC) continues to have the highest incidence of all gynecological malignancies. The burden of morbidity and mortality in developing regions is also rising quickly, especially for advanced CC. Along with apoptosis, iron death, and other forms of programmed cell death, pyroptosis is a significant inflammatory process. Its connection to the malignancy mechanism has been verified. The expression of genes linked to pyroptosis in CC tissue and its relationship to prognosis, however, remain poorly understood. Using The Cancer Genome Atlas, we first discovered 13 differentially expressed pyroptosis-related genes (DE-PRGs) in the study (TCGA). Based on DE-PRGs, CC patients were divided into four subtypes. The 4 parts' times showed large variations according to the K-M curve. Then, using the least absolute shrinkage and selection operator (LASSO) Cox regression method, we created a mod el for predicting CC based on pyroptosis-associated genes. There were significant differences in overall survival (OS) times involving the high-risk and low-risk groups for all CC patients in the TCGA group, who were divided into lowrisk and high-risk groups (p equals 0.0441). The risk score status as an independent prognostic factor for CC was confirmed by independent prognostic predictor validation. The analyses of single-sample gene set and enrichment analysis (ssGSEA), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) all revealed significant differences in immune cells and immune pathways involving high-and lowrisk groups (p less than 0.001), indicating a weakened immune status in high-risk groups. In conclusion, pyroptosis-associated genes are involved in tumor immunity and can help determine a patient's prognosis for CC. As a result, we have created and validated a signature that is related to pyroptosis and predicts CC prognosis, which may aid in early diagnosis, prognostic analysis, and immunotherapy.

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“…The data analysis was performed using SPSS-22 software. All results were compared using two-sided and p-values lower than 0.05 were taken as statistically significant (Behboodi et al 2021).…”

Section: Statisticsmentioning

confidence: 99%

Association of a genetic variant in the ATP-binding cassette sub-family B member 1 with risk of cervical cancer

Armanpour¹,

Malekzade²,

Maftooh³

et al. 2022

Human Gene

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Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer

Cited by 7 publications

References 20 publications

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

A novel pyroptosis-related gene signature for predicting the prognosis of cervical cancer

Association of a genetic variant in the ATP-binding cassette sub-family B member 1 with risk of cervical cancer

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