Association of a Vitamin D Receptor Gene Polymorphism With Localized Early‐Onset Periodontal Diseases

Abstract

These data indicate that carriage of the less frequent allele of the Taq I RFLP (t) in the VDR gene significantly increases the risk of developing L-EOP. However, VDR genotype may not affect the incidence of all cases of EOP. These findings contribute to our understanding of the genetic basis for periodontal disease and may help define sub-groups of this disease which share common pathogenic factors.

Vitamin D receptor gene polymorphism associates with graft-versus-host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation

“…PCR for the relevant regions of the VDR gene and restriction enzyme digestion of the products were done essentially as described for the FokI, 1 BsmI, 2 ApaI 3 and TaqI. 3 RFLPs. All restriction digests were done with a five-fold excess of enzyme to avoid partial digest products.…”

“…Homozygosity for the closely linked bb and aa genotypes of the BsmI and ApaI RFLPs in intron 8 is associated with increased femoral and vertebral bone density. 3,4,7 Reduced bone loss associated with liver transplantation is less frequent in transplant patients who possess the BsmI and ApaI aa and bb genotypes for VDR. 8 Polymorphism at the ATG initiation codon (FokI site) has been associated with genetic determination of final height in Japanese subjects, with heterozygotes at this locus achieving a greater final height than homozygotes for either allele, 1 and with heritable variation in bone mineral density.…”

“…11 VDR gene polymorphism has also been linked with susceptibility to infectious disease. Polymorphism at the TaqI site has been associated with localised early onset periodontal disease 3 and with susceptibility to leprous and tubercular subtypes of leprosy. 12 The VDR has an important role in the development of the immune system.…”

Genes and Gene Polymorphisms Associated with Periodontal Diesases

“…Periodontal hastalığın başlaması ve ilerlemesinde etkili interleukin-1 (IL-1), tümör nekroz faktörü-α (TNF-α) gibi sitokinler, insan lökosit antijenleri (HLA) ve matris metalloproteinazlar (MMPs), katepsin-C, vitamin D gibi proteaz ve yapısal moleküllerin ekspresyonunda etkili genlerin yanı sıra, immünoreseptörler ile ilgili pek çok çalışma yapılmıştır. 22,[31][32][33][34][35][36][37][38][39][40][41] Tedavi edilen ve edilmeyen periodontitisli hastalarda yapılan uzun dönemli çalışmalara göre periodontitisin ilerlemesinde kişisel değişiklikler olduğu belirlenmiştir. 17,42,43 Löe ve arkadaşları, 17 ağız bakımının bulunmadığı veya zayıf günlük mikrobiyal dental plak kontrolüne sahip Sri Lanka çay bitkisi işçileri üzerinde 15 yıl süren çalışmaları sonucunda, toplumun %81'inde orta ve %8'inde hızlı seviyede periodontal hastalık ilerlemesi görülürken, %11'inde ise periodontal hastalığın ilerlemediğini saptamışlardır.…”

Dinucleotide repeat polymorphism in the interleukin-10 gene promoter (IL-10.G) and genetic susceptibility to early-onset periodontal disease

“…22 Our previous work has indicated that SNPs in the IL-1␤ and vitamin D receptor (VDR) genes are associated with various clinical sub-groups of EOP indicating a role of genetic polymorphism in EOP. 13,25 It is important to recognise that although genetic association studies are considered to be sensitive enough to detect genes with modest effect they are affected by differences between populations and population stratification. 26 Other problems with the design of genetic association studies include variability of results between studies due to weak effect on phenotype or weak linkage disequilibrium.…”