Association of abnormal lipid spectrum with the disease activity of Takayasu arteritis

Abstract

Our study aimed to determine whether proatherogenic lipid profiles exist in patients with active Takayasu arteritis (TA) and assess the relationship between different lipid profiles and disease activity in TA. A total of 132 premenopausal female patients with TA and 100 sex-, age-, and body mass index-matched healthy controls were included in our study. The clinical data were collected in detail from all participants. Patients with active TA had significantly lower levels of apolipoprotein A1 (apoA1) (1.47 ± 0.30 vs. 1.99 ± 0.33 mmol/L, p < 0.001) and lower levels of high-density lipoprotein cholesterol (HDL-C) (1.23 ± 0.33 vs. 1.68 ± 0.38 mmol/L, p < 0.001) than patients with inactive TA. However, they had higher ratios of apolipoprotein B (apoB)/apoA1 (0.74 ± 0.27 vs. 0.48 ± 0.14, p < 0.001) compared with patients with inactive TA. Multiple linear regression analysis demonstrated that the apoB/apoA1 ratio was independently associated with TA activity (β = 0.38, p = 0.04). In addition, multivariate stepwise forward regression analysis showed that the apoB/apoA1 ratio was the major determinant for high-sensitivity C-reactive protein (β = 0.58, p = 0.002). Our findings indicate that patients with active TA had proatherogenic lipid profiles. In addition, the ratio of apoB to apoA1 could be used as a marker for monitoring and targeting patients with TA.

Clinical study of children with Takayasu arteritis: a retrospective study from a single center in China

“…Some adult TA patients showed dyslipidemia, which may be a risk factor for complicating atherosclerosis [22]. Also, dyslipidemia is suggestive of disease activity [23]. Here, dyslipidemia was identified in 60% (3/5) of cases, similar to that reported previously [22]; however, the disease activity scores for children with and without dyslipidemia were not statistically different.…”

Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis

“…In the majority of papers, patients with active disease presented with higher ESR and CRP levels as compared with patients with stable/inactive disease (ESR ranged 5–115 mm/hour vs 1–43 mm/hour and CRP ranged 0.1–99.1 mg/dL vs 0.06–7.77 mg/dL for active vs stable disease, respectively). Nevertheless, 28.5% of patients classified as being in remission (National Institutes of Health (NIH) criteria) may present with elevated CRP and 23.8% with elevated ESR23 (overall LoE 4) 23–29…”

“…In one case–control study (n=120), high-sensitivity CRP was a significant predictor of major cardiac events 30. Adding to cardiovascular risk, patients with TAK present a more atherogenic lipid profile when compared with healthy controls, but not when compared with coronary artery disease controls 26 30…”

Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm

“…Lipid metabolism disorders are related to the activity of TAK 14 . Inflammatory cytokines such as interleuken-6 and tumor necrosis factor-α can promote the LDL receptor-independent uptake of oxidized LDL.…”

“…There is a lack of knowledge about aneurysm risk in TAK patients due to the rarity of the disease. Previous studies have found that prevalent of dyslipidemia in patients with TAK was 19–47% 10–13 , and that lipids disorders are related to the activity of TAK 14 . The purpose of this study was to investigate the clinical and laboratory features of TAK and to analyze the combination of TAK and dyslipidemia as a risk factor for aneurysm formation.…”