Association of Abnormal Ovarian Reserve Parameters With a Higher Incidence of Aneuploid Blastocysts

Abstract

II.

Association of body mass index with embryonic aneuploidy

“…Analysis of pooled data demonstrated a higher miscarriage rate in obese versus normal-BMI women (7). In an analysis of tissue karyotypes from women with first-trimester miscarriages, overweight and obese women aged <35 years were actually less likely to have aneuploid miscarriages than women in a healthy weight range, suggesting that miscarriages in young overweight/obese women may be due to factors other than aneuploidy (26). However, the women in that study conceived by various modes of conception, ranging from natural conception to all forms of assisted reproduction, thus adding significant confounders.…”

“…Our results suggest that the negative impact of being overweight or obese on reproductive outcomes may not be related to embryonic aneuploidy. Age is undisputedly the most important prognostic factor related to embryo ploidy (23), and ovarian reserve has been inconsistently correlated with chromosomal competence (24)(25)(26). To account for the universally accepted confounder of age and the potential confounder of ovarian reserve, our models adjusted for age and day-2 FSH.…”

“…However, the women in that study conceived by various modes of conception, ranging from natural conception to all forms of assisted reproduction, thus adding significant confounders. Notably, the only women included were those having a dilation and curettage (D&C) after miscarriage, thus missing the cohort of women with subclinical pregnancy loss due to aneuploidy, those who miscarried spontaneously, those who were treated medically, and women who underwent dilation and curettage without karyotyping (26).…”

Antimüllerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng/mL versus 1–4 ng/mL

“…An AMH level of >1 ng/mL regardless of cycle day was considered to be normal (20,21). The women were grouped as follows: <35 years of age with AMH <1 ng/mL (n ¼ 40) or AMH of 1-4 ng/mL (n ¼ 77); and R35 years of age with AMH <1 ng/mL (n ¼ 62) or AMH of 1-4 ng/mL (n ¼ 68).…”

Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis

“…Estrogen is one of the major inducer of aromatase gene expression in granulosa cells that provides a positive feedback loop during folliculogenesis to stimulate steroidogenesis [19]. This action of estrogen is also mediated by the activation of ERβ [20].…”